Skip to main content
Log in

Pharmacokinetic Properties of the Newer Cephalosporins

A Valid Basis for Drug Selection?

  • Leading Article
  • Published:
Drugs Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Alestig, K.; Carlberg, H.; Nord, C.E. and Trollfors, B.: Effect of cefoperazone on fecal flora. Journal of Antimicrobial Chemotherapy 12: 163–167 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Andrassy, K.; Koderisch, J. and Ritz, E.: Influence of cefotaxime, cefoperazone, and lamoxactam on hemostasis; in Proceedings of the 22nd ICAAC, Abstract 523 (American Society for Microbiology, Washington, DC 1982).

    Google Scholar 

  • Bang, N.U.; Tessler, S.S.; Heidenreich, R.O.; Marks, C.A. and Mattler, L.E.: Effects of moxalactam on blood coagulation and platelet function. Reviews of Infectious Diseases 4 (Suppl.): S546–S554 (1981).

    Article  Google Scholar 

  • Barza, M. and Butler, E.: The penetration of penicillins and cephalosporins into selected sites of clinical interest; in Weinstein and Fields (Eds) Seminars in Infectious Diseases, Vol. III, pp. 193–224 (Thieme-Stratton, New York 1980).

    Google Scholar 

  • Bodey, G.P.; Fainstein, V.; Garcia, I.; Rosenbaum, B. and Wong, Y.: Effect of broad-spectrum cephalosporins on the microbial flora of recipients. Journal of Infectious Diseases 148: 892–897 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Brogden, R.N.; Carmine, A.; Heel, R.C.; Morley, P.A.; Speight, T.M. and Avery, G.S.: Cefoperazone: A review of its in vitro antimicrobial activity, pharmacological properties and therapeutic efficacy. Drugs 22: 423–460 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Bundtzen, R.; Craig, W.; Toothaker, R. et al.: Cefoperazone: Single-dose pharmacokinetics; in Proceedings of the 20th ICAAC, Abstract 112 (American Society for Microbiology, Washington. DC 1980).

    Google Scholar 

  • Carmine, A.A.; Brogden, R.N.; Heel, R.C.; Speight, T.M. and Avery, G.S.: Cefotaxime. A review of its activity, pharmacological properties and therapeutic use. Drugs 25: 223–289 (1983a).

    Article  PubMed  CAS  Google Scholar 

  • Carmine, A.A.; Brogden, R.N.; Heel, R.C.; Romankiewicz, J.A.; Speight, T.M. and Avery, G.S.: Moxalactam (latamoxef): A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 26: 279–333 (1983b).

    Article  PubMed  CAS  Google Scholar 

  • Chin, N. and Neu, H.C.: Cefotaxime and desacetylcefotaxime: An example of advantageous antimicrobial metabolism. Diagnostic Microbiology and Infectious Diseases 2: 215–225 (1984).

    Google Scholar 

  • Conly, J.M.; Ramotar, K.; Chubb, H.; Bow, E.J. and Louie, T.J.: Hypoprothrombinemia in febrile, neutropenic patients with cancer: Association with antimicrobial suppression of intestinal microflora. J. Infect. Dis. 150: 202–212 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Coombs, J.D.: Metabolism and pharmacokinetics of new cephalosporin agents; in Neu (Ed.) New Beta Lactam Antibiotics: A Review from Chemistry to Clinical Efficacy of the New Cephalosporins, pp. 177–214 (College of Physicians of Philadelphia, Philadelphia 1982).

    Google Scholar 

  • Cunha, B.; Ristuccia, A. and Jonas, M.: Tissue penetration characteristics of ceftizoxime and cefazolin in human bile and gallbladder wall. Journal of Antimicrobial Chemotherapy 10(Suppl. C): 117–120 (1982).

    PubMed  Google Scholar 

  • Demos, P.: Clinical aspects of ceftriaxone; in Neu (Ed.) New Beta Lactam Antibiotics: A Review from Chemistry to Clinical Efficacy of the New Cephalosporins, pp. 263–274 (College of Physicians of Philadelphia, Philadelphia 1982).

    Google Scholar 

  • Fitzpatrick, B.J. and Staniford, H.C.: A comparative evaluation of moxalactam. Pharmacotherapy 2: 197–212 (1982).

    PubMed  CAS  Google Scholar 

  • Funk, E.A. and Strasbaugh, L.J.: Antimicrobial activity, pharmacokinetics, adverse reactions, and therapeutic indications of cefoperazone. Pharmacotherapy 2: 188–189 (1982).

    Google Scholar 

  • Gower, P.E. and Hobbs, P.M.: The kinetics of ceftazidime in renal impairment; in Program and Abstracts of the 12th ICC, Florence, Italy (1981).

  • Greenfield, R.A.; Gerber, A.U. and Craig, W.A.: Pharmacokinetics of cefoperazone in patients with normal and impaired renal function. Reviews of Infectious Diseases 5 (Suppl.): S127–S136 (1983).

    Article  PubMed  Google Scholar 

  • Guggenbicher, J.P. and Kofler, J.: Influence of third-generation cephalosporins on aerobic intestinal flora. Journal of Antimicrobial Chemotherapy 14(Suppl. B): 67–70 (1984).

    Google Scholar 

  • Hentges, D.J.: Role of the intestinal microflora in host defense against infection; in Hentges (Ed.) Human Intestinal Microflora in Health and Disease, pp. 311–331 (Academic Press, New York 1983).

    Google Scholar 

  • Jones, R.N.; Barry, A.L. and Thornsberry, C.: Antimicrobial activity of desacetylcefotaxime alone and in combination with cefotaxime: Evidence of synergy. Reviews of Infectious Diseases 4 (Suppl.): S366–S373 (1982).

    Article  PubMed  Google Scholar 

  • Kemmerich, B.; Warns, H.; Lode, H.; Borner, K.; Koeppe, P. and Knothe, H.: Multiple-dose pharmacokinetics of ceftazidime and its influence on fecal flora. Antimicrobial Agents and Chemotherapy 24: 333–338 (1983).

    Article  PubMed  CAS  Google Scholar 

  • LeFrock, J.L.; Prince, R.A. and Leff, R.D.: Mechanism of action, antimicrobial activity, pharmacology, adverse effects, and clinical efficacy of cefotaxime. Pharmacotherapy 2: 177 (1982).

    Google Scholar 

  • LeRoy, A.; Humbert, G. and Filastre, J.P.: Pharmacokinetics of moxalactam in subjects with normal and impaired renal function. Antimicrob. Agents Chemoth. 19: 965–971 (1981).

    Article  CAS  Google Scholar 

  • Lipsky, J.J.: Mechanisms of the inhibition of the gamma-carboxylation of glutamic acid by N-methylthiotetrazole containing antibiotics. Proceedings of the National Academy of Sciences 81: 2893–2987 (1984).

    Article  CAS  Google Scholar 

  • Lode, H.; Warns, H.; Kemmerich, B.; Knothe, H. and Koeppe, P.: Ceftizoxime: Multiple-dose pharmacokinetics and their effect on fecal flora; in Proceedings of the 21st ICAAC, Abstract 37 (American Society for Microbiology, Washington, DC 1981).

    Google Scholar 

  • Luthy, R.; Blaser, J.; Bonetti, A.; Simmon, H.; Wise, R. and Sigenthaler, W.: Comparative multiple-dose pharmacokinetics of cefotaxime, moxalactam, and ceftazidime. Antimicrobial Agents and Chemotherapy 21: 567–575 (1981).

    Article  Google Scholar 

  • Malmborg, A.S.; Kager, L. and Nord, C.E.: Effect of moxalactam on bowel flora in patients undergoing colorectal surgery; in Proceedings of the 23rd ICAAC, Abstract 127 (American Society for Microbiology, Washington, DC 1983).

    Google Scholar 

  • Martin, E. and Guggi, T.: Single daily dose short course treatment of pediatric meningitis with ceftriaxone; in Proceedings of the 24th ICAAC (American Society for Microbiology, Washington, DC 1984).

    Google Scholar 

  • Moreau, L.; Durand, H. and Biclet, P.: Cefotaxime concentrations in ascites. J. Antimicrob. Chemoth. 6(Suppl. A): 121–122 (1980).

    Google Scholar 

  • Moskovitz, B.L.: Clinical adverse effects during ceftriaxone therapy, American J. Med. 77(Suppl. 4C): 84–88 (1984).

    CAS  Google Scholar 

  • Neu, H.C.: The new beta-lactamase stable cephalosporins. Annals of Internal Medicine 97: 408–419 (1982).

    PubMed  CAS  Google Scholar 

  • Neu, H.C.: Ceftizoxime: A beta-lactamase-stable, broad-spectrum cephalosporin. Pharmacotherapy 4: 51 (1984).

    Google Scholar 

  • Neu, H.C. and Prince, A.S.: Interactions between moxalactam and alcohol. Lancet 1: 1422 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Norrby, S.R.: The place of cephalosporins in the treatment of bacterial meningitis in adults; in Moellering and Neu (Eds) Advances in Cephalosporin Therapy: Beyond the Third Generation (Health Projects International, Phoenix 1984).

    Google Scholar 

  • Owens, N.J.; Nightingale, C.H.; Quinliliani, R. and Hickingbotham, J.M.: Ceftriaxone penetration pharmacokinetics in serum, bile, and gallbladder wall; in Proceedings of the 22nd ICAAC (American Society for Microbiology, Washington, DC 1982).

    Google Scholar 

  • Parsons, J.; Romano, J. and Levison, M.: Pharmacology of a new 1-oxa-beta-lactam in normal volunteers. Antimicrobial Agents and Chemotherapy 19: 302–305 (1981).

    Article  Google Scholar 

  • Patel, I. and Kaplan, S.: Pharmacokinetic profile of ceftriaxone in man. American J. Med. 77(Suppl. 4C): 17–25 (1984).

    CAS  Google Scholar 

  • Richards, D.M. and Brogden, R.N.: Ceftazidime: A Review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 29: 105–161 (1985).

    Article  PubMed  CAS  Google Scholar 

  • Richards, D.M. and Heel, R.C.: Ceftizoxime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 29: 281–329 (1985).

    Article  PubMed  CAS  Google Scholar 

  • Richards, D.M.; Heel, R.C.; Brogden, R.N.; Speight, T.M. and Avery, G.S.: Ceftriaxone. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs 27: 469–527 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Ruf, B.: Penetration of ceftizoxime (FK 749) into the cerebrospinal fluid. Infection 10: 76–80 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Saito, A.: Studies on absorption, distribution, metabolism, and excretion of ceftazidime in Japan. Journal of Antimicrobial Chemotherapy 12(Suppl. A): 255–262 (1983).

    PubMed  Google Scholar 

  • Shah, P.M.; Knobloch, M. and Haag, R.: Pharmacokinetics of ceftizoxime in patients undergoing hemodialysis. Methods in Experimental and Clinical Pharmacology 4: 185–188 (1982).

    CAS  Google Scholar 

  • Shimada, J. and Ueda, Y.: Moxalactam: Absorption, excretion, distribution, and metabolism. Reviews of Infectious Diseases 4 (Suppl.): S569–S580 (1982).

    Article  PubMed  Google Scholar 

  • Swarz, H.; Fay, D.; Siemans, A.J. and Fishman, S.K.: The clinical aspects of cefoperazone; in Neu (Ed.) New Beta Lactam Antibiotics: A Review from Chemistry to Clinical Efficacy of the New Cephalosporins, pp. 243–262 (College of Physicians of Philadelphia, Philadelphia 1982).

    Google Scholar 

  • Weitekamp, M.R. and Aber, R.C.: Prolonged bleeding times and bleeding diathesis associated with moxalactam administration. Journal of the American Medical Association 249: 69–71 (1983).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Noble, J.T., Barza, M. Pharmacokinetic Properties of the Newer Cephalosporins. Drugs 30, 175–181 (1985). https://doi.org/10.2165/00003495-198530030-00001

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-198530030-00001

Keywords

Navigation