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β-Adrenoceptor Blockers

An Update on their Role in Acute Myocardial Infarction

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References

  • Beta Blocker Heart Attack Trial Research Group: A randomized trial of propranolol in patients with acute myocardial infarction. 1. Mortality results. Journal of the American Medical Association 247: 1707–1714 (1982).

    Article  Google Scholar 

  • Boyle, D.McC.; Baxter, J.M.; Mcllmoyle, E.L.; Salathia, K.S.; Evans, A.E.; Cran, G.; Elwood, J.H. and Shanks, R.G.: Effects of very early intervention with metoprolol on myocardial infarct size. British Heard Journal 49: 229–233 (1983).

    Article  CAS  Google Scholar 

  • Boyle, D.McC. and Salathia, K.S.: Very early intervention with metoprolol in suspected acute myocardial infarction. Paper presented at an International Symposium on the Role of Beta Blockers in Acute Myocardial Ischaemia and Infarction, Rome, October 29–30, 1984. Editorial: Adrenaline and potassium: Everything influx. Lancet 2: 1401–1403 (1983).

    Google Scholar 

  • Furberg, C.D.; Morton-Hawkins, C. and Lichstein, E.: Effect of propranolol in post-infarction patients with mechanical or electrical complications. Circulation 69: 761–765 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Herlitz, J.; Elmfeldt, D.; Hjalmarson, A.; Holmberg, S.; Malek, I.; Nyberg, G.; Ryden, L.; Swedburg, K.; Vedin, A.; Waagstein, F.; Waidenstrom, A.; Waidenstrom J.; Wedel, H.; Wihelmsen, L. and Wilhelmsson, C: Effect of metoprolol on indirect signs of size and severity of acute myocardial infarction. American Journal of Cardiology 51: 1282–1288 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Hjalmarson, A.: The MIAMI trial: Effects on mortality. Paper presented at an International Symposium on the Role of Beta Blockers in Acute Myocardial Ischaemia and Infarction, Rome, October 29–30, 1984. International Collaborative Study Group: Reduction of infarct size with the early use of timolol in acute myocardial infarction. New England Journal of Medicine 310: 9–15 (1984).

    Article  Google Scholar 

  • Jurgensen, S.J.: Frederickson, J.; Hansen, V.A. and Pedersen-Bjergaard, O: Limitation of myocardial infarct size in patients less than 66 years treated with alprenolol. British Heart Journal 45: 583–588 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Mullane, J.E.; Kaufman, J.; Dvornik, D. and Coelho, J.: Propranolol dosage, plasma concentration and beta blockade. Clinical Pharmacology and Therapeutics 32: 692–700 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Nordrehaug, J.E. and von der Lippe, G.: Hypokalaemia and ventricular fibrillation in acute myocardial infarction. British Heart Journal 50: 525–529 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Norris, R.M.; Barnaby, P.F.; Brandt, P.W.T.; Geary, G.G.: Whitchlock, R.M.L.; Wilde, CJ. and Barratt-Boyes, B.G.: Prognosis after recovery from first acute myocardial infarction: Determinants of reinfarction and sudden death. American Journal of Cardiology 53: 408–413 (1984a).

    Article  PubMed  CAS  Google Scholar 

  • Norris, R.M.; Barnaby, P.F.; Brown, M.A.; Geary G.G.; Clarke, ED.; Logan, R.L. and Sharpe, D.N.: Prevention of ventricular fibrillation during acute myocardial infarction by intravenous propranolol. Lancet 2: 883–886 (1984b).

    Article  PubMed  CAS  Google Scholar 

  • Norris, R.M.; Sammel, N.L.; Clarke, E.D. and Brandt, P.W.T.: Treatment of acute myocardial infarction with propranolol. Further studies on enzyme appearance and subsequent left ventricular function in treated and control patients with developing infarcts. British Heart Journal 43: 617–622 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Norris, R.M.; Sammel, N.L.; Clarke, ED.; Smith, W.M. and Williams, B.: Protective effect of propranolol in threatened myocardial infarction. Lancet 2: 907–909 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Norwegian Multicenter Study Group: Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. New England Journal of Medicine 304: 801–807 (1981).

    Article  Google Scholar 

  • Olsson, G.; Hjemdahl, P. and Rehnqvist, N.: Rebound phenomena following gradual withdrawal of chronic metoprolol treatment in patients with ischaemic heart disease. American Heart Journal 108: 454–462 (1984b).

    Article  PubMed  CAS  Google Scholar 

  • Olsson, G.; Rehnqvist, N.; Sjogren, A.; Erhardt, C. and Lundman, T.: Long-term treatment with metoprolol after myocardial infarction. Report on 3 year mortality and morbidity. Journal of the American College of Cardiology (In press, 1984a).

  • Owensby, D.A. and O’Rourke, M.F.: Failure of pindolol to alter determinants of myocardial oxygen requirements, enzyme release or clinical course in acute myocardial infarction. Circulation 70 (Suppl. II): 11–156 (1984).

    Google Scholar 

  • Paxton, J.W. and Norris, R.M.: Propranolol distribution after acute myocardial infarction. Clinical Pharmacology and Therapeutics 36: 337–342 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Peter, T.; Norris, R.M.; Clarke, ED.; Henry, M.K.; Singh, B.N.; Williams, B.; Howell, D.R. and Ambler, P.K.: Reduction of enzyme levels by propranolol after acute myocardial infarction. Circulation 57: 1091–1095 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Reimer, K.A.; Lowe, J.E.; Rasmussen, M.M. and Jennings, R.B.: The wavefront phenomenon of ischaemic cell death. I. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation 56: 786–794 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Roberts, R.; Croft, G; Gold, H.K.; Hartwell, T.D.; Jaffe, A.S.; Muller, J.E; Mullin, S.M.; Parker, C; Passammani, ER.; Poole, W.K.; Raabe, D.S.; Rude, R.E; Stone, P.H.; Tun, Z.G.; Sobel, B.E; Willerson, J.T. and Braunwald, E.B.: Effect of propranolol on myocardial infarct size in a randomized blinded multicenter trial. New England Journal of Medicine 311: 218–224 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Roubin, G.S.; Harris, P.J.; Bernstein, L. and Kelly, D.T.: Coronary anatomy and prognosis after myocardial infarction in patients 60 years of age and younger. Circulation 67: 743–749 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Ryden, L.: The MIAMI trial: Effects on arrhythmias. Paper presented at an International Symposium on the Role of Beta Blockers in Acute Myocardial Ischaemia and Infarction, Rome, October 29–30, 1984.

  • Ryden, L.; Ariniego, R.; Amman, K.; Herlitz, J.; Hjalmarson, A.; Holmberg, S.; Reyes, C; Smedgard, P.; Swedberg, K.; Vedin, A.; Waagstein, F.; Waidenstrom, A.; Wilhelmsson, G; Wedel, H. and Yamamoto, M.: A double-blinded trial of metoprolol in acute myocardial infarction. Effect on ventricular tachyarrhythmias. New England Journal of Medicine 308: 614–618 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Vedin, A.: The MIAMI trial: Other clinical findings and tolerance. Paper presented at an International Symposium on the Role of Beta Blockers in Acute Myocardial Infarction, Rome, October 29–30, 1984.

  • Wilhelmsson, C: The MIAMI trial: Methodology and patient population. Paper presented at an International Symposium on the Role of Beta Blockers in Acute Myocardial Infarction and Ischaemia, Rome, October 29–30, 1984.

  • Yusuf, S.; Furberg, C; Collins, R. and Peto, R.: Beta blockers with intrinsic sympathomimetic activity are less beneficial after myocardial infarction. Circulation 70 (Suppl. II): II–6 (1984b).

    Google Scholar 

  • Yusuf, S.; Peto, R.; Lewis, J.; Collins, R. and Sleight, P.: Beta blockade during and after myocardial infarction: An overview of the randomised trials. Progress in Cardiovascular Disease (In press, 1984a).

  • Yusuf, S.; Sleight, P.; Rossi, P.; Ramsdale, D.; Peto, R.; Furze, L.: Scerry, H.; Pearson, M.; Motwani, R.; Parish, S.; Gray, R.; Bennett, D. and Bray, C: Reduction in infarct size, arrhythmias and chest pain by early intravenous beta blockade in suspected acute myocardial infarction. Circulation 67 (Suppl. I): 32–41 (1983).

    Google Scholar 

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  1. Coronary Care Unit, Green Lane Hospital, Auckland 3, New Zealand

    Robin M. Norris

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  1. Robin M. Norris
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Norris, R.M. β-Adrenoceptor Blockers. Drugs 29, 97–104 (1985). https://doi.org/10.2165/00003495-198529020-00001

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