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Diuretics

Clinical Pharmacology and Therapeutic Use (Part I)

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Summary

25 years have elapsed since the introduction of the first effective oral diuretic, chlorothiazide. Diuretics are now amongst the most widely prescribed drugs in clinical practice worldwide. Availability of these drugs has not only brought therapeutic benefit to countless numbers of patients but it has at the same time provided valuable research tools with which to investigate the functional behaviour of the kidney and other electrolyte-transporting tissues.

Despite many remaining gaps in our knowledge of the biochemical processes involved in diuretic drug action, available compounds can be divided into 5 groups on the basis of their preferential effects on different segments of the nephron involved in tubular reabsorption of sodium chloride and water. Firstly, there is a heterogeneous group of chemicals that share the common property of powerful, short- lived diuretic effects that are complete within 4 to 6 hours. These agents act on the thick ascending limb of Henle’s loop and are known as ‘high ceiling’ or ‘loop’ diuretics. The second group are the benzothiadiazines and their many related heterocyclic variants, all of which localise their effects to the early portion of the distal tubule. The third group comprises the potassium- sparing diuretics which act exclusively on the Na+- K+/H+ exchange mechanisms in the late distal tubule and cortical collecting duct. The action of drugs in groups 2 and 3 is prolonged to between 12 and 24 hours. The fourth group consists of diuretics that are chemically related to ethacrynic acid but have the unusual property of combining within the same molecule the property of saluresis and uricosuria. These compounds have actions, to different individual extents, in the proximal tubule, thick ascending limb, and early distal tubule and are known as ‘polyvalent’ diuretics. Finally, there is a mixed group of weak or adjunctive diuretics which includes the vasodilator xanthines such as aminophylline, and the osmotically active compounds such as mannitol.

Available evidence on the molecular mechanisms of action of diuretics in each group is reviewed. The haemodynamic, humoral and physical factors involved in control of electrolyte and fluid handling by the kidney in normal conditions and pathological states are discussed in relation to rational choices of different diuretics in the treatment of various oedematous and non-oedematous conditions.

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References

  • Acchiardo, S.R. and Skoutakis, V.A.: Clinical efficacy, safety, and pharmacokinetics of indapamide in renal impairment. American Heart Journal 106: 237–244 (1983).

    PubMed  CAS  Google Scholar 

  • Aiton, J.F.; Chipperfield, A.R.; Lamb, J.F.; Ogden, P. and Simons, N.L.: Occurrence of passive furosemide-sensitive transmembrane potassium transport in cultured cells. Biochimica et Biophysica Acta 646: 389–398 (1981).

    PubMed  CAS  Google Scholar 

  • Allgulander, C.; Beermann, B. and Sjögren, A.: Frusemide pharmacokinetics in patients with liver disease. Clinical Pharmacokinetics 5: 570–575 (1980).

    PubMed  CAS  Google Scholar 

  • Andreasen, F.; Hansen, U.; Husted, S.E. and Jansen, J.A.: The pharmacokinetics of frusemide are influenced by age. British Journal of Clinical Pharmacology 6: 391–397 (1983).

    Google Scholar 

  • Andreasen, F. and Mickelsen, P.: Determination of furosemide in blood plasma and its binding to proteins in normal plasma from patients with acute renal failure. Acta Pharmacologica et Toxicologica 35: 49–57 (1974).

    PubMed  CAS  Google Scholar 

  • Anggard, E. and Oliw, E.: Formation and metabolism of prostaglandins in the kidney. Kidney International 19: 771–780 (1981).

    PubMed  CAS  Google Scholar 

  • Asbury, M.J.; Gatenby, P.B.B.; O’Sullivan, S. and Bourke, E.: Bumetanide: Potent new ‘Loop’ diuretic. British Medical Journal 1: 211–213 (1972).

    PubMed  CAS  Google Scholar 

  • Attalah, A.A.: Interaction of prostaglandins with diuretics. Prostaglandins 18: 369–375 (1979).

    Google Scholar 

  • Baer, J.E. and Beyer, K.H.: Subcellular pharmacology of natriuretic and potassium-sparing drugs. Progress in Biochemistry and Pharmacology 7: 59–93 (1972).

    CAS  Google Scholar 

  • Bailie, M.D.; Crosslan, K. and Hook, J.B.: Natriuretic effect of furosemide after inhibition of prostaglandins synthetase. Journal of Pharmacology and Experimental Therapeutics 199: 469–476 (1976).

    PubMed  CAS  Google Scholar 

  • Barger, A.C. and Sparks Jr, H.V.: Renal haemodynamics in congestive cardiac failure; in Lant and Wilson (Eds) Modern Diuretic Therapy in the Treatment of Cardiovascular and Renal Disease, pp.3–24 (Excerpta Medica, Amsterdam 1973).

    Google Scholar 

  • Beermann, B.; Dalen, E.; Lindstrom, B. and Rosen, A.: On the fate of furosemide in man. European Journal of Clinical Pharmacology 9: 57–61 (1975).

    CAS  Google Scholar 

  • Bcermann, B. and Groschinsky-Grind, M.: Pharmacokinetics of hydrochlorothiazide in patients with congestive failure. British Journal of Clinical Pharmacology 7: 579–583 (1979).

    Google Scholar 

  • Beermann, B. and Groschinsky-Grind, M.: Clinical pharmacokinetics of diuretics. Clinical Pharmacokinetics 5: 221–245 (1980).

    PubMed  CAS  Google Scholar 

  • Beermann, B.; Groschinsky-Grind, M. and Lindstrom, B.: Pharmacokinetics of bendroflumethiazide. Clinical Pharmacology and Therapeutics 22: 385–388 (1977).

    PubMed  CAS  Google Scholar 

  • Belair, E.J.; Cohen, A.I. and Yelnosky, J.: Renal excretion of metolazone, a new diuretic. British Journal of Pharmacology 45: 476–479 (1972).

    PubMed  CAS  Google Scholar 

  • Bengtsson, C.; Johnsson, G.; Sannerstedt, R. and Werko, L.: Effect of different doses of chlorthalidone on blood pressure, serum potassium, and serum urate. British Medical Journal 1: 197–199 (1975).

    PubMed  CAS  Google Scholar 

  • Berg, K.J.; Walstad, R.A. and Bergh, K.: The pharmacokinetics and diuretic effects of piretanide in chronic renal insufficiency. British Journal of Clinical Pharmacology 15: 347–353 (1983).

    PubMed  CAS  Google Scholar 

  • Beyer, K.H.; Baer, J.E.; Michaelson, J.K. and Russo, H.F.: Renotropic characteristics of ethacrynic acid: A phenoxyacetic saluretic-diuretic agent. Journal of Pharmacology and Experimental Therapeutics 147: 1–22 (1965).

    PubMed  CAS  Google Scholar 

  • Blantz, R.C. and Pelayo, J.C.: A functional role for the tubuloglomerular feedback mechanism. Kidney International 25: 739–746 (1984).

    PubMed  CAS  Google Scholar 

  • Bourland, W.A.; Day, D.K. and Williamson, H.E.: The role of the kidney in the early non-diuretic action of furosemide to reduce left atrial pressure in the hypervolemic dog. Journal of Pharmacology and Experimental Therapeutics 202: 211–229 (1977).

    Google Scholar 

  • Branch, R.A.; Read, P.R.; Levine, D.; Elst, E.V.; Shelton, J.; Rupp, W. and Ramsay, L.E.: Furosemide and bumetanide: A study of responses in normal English and German subjects. Clinical Pharmacology and Therapeutics 19: 538–545 (1976).

    PubMed  CAS  Google Scholar 

  • Brater, D.C.: Increase in diuretic effect of chlorothiazide by probenecid. Clinical Pharmacology and Therapeutics 23: 259–265 (1978).

    PubMed  CAS  Google Scholar 

  • Brater, D.C.: Renal sites of action of azosemide. Clinical Pharmacology and Therapeutics 25: 428–434 (1979a).

    PubMed  CAS  Google Scholar 

  • Brater, D.C.: Analysis of the effect of indomethacin on the response to frusemide in man: Effect of dose of furosemide. Journal of Pharmacology and Experimental Therapeutics 210: 386–390 (1979b).

    PubMed  CAS  Google Scholar 

  • Brater, D.C.: Pharmacodynamic considerations in the use of diuretics. Annual Review of Pharmacology and Toxicology 23: 45–62 (1983).

    PubMed  CAS  Google Scholar 

  • Brater, D.C.; Anderson, S.A. and Strowing, S.: Azosemide, a ‘loop’ diuretic, and furosemide. Clinical Pharmacology and Therapeutics 25: 435–439 (1979).

    PubMed  CAS  Google Scholar 

  • Brater, D.C. and Chennavasin, P.: Effects of probenecid on response to bumetanide in man. Journal of Clinical Pharmacology 21: 311–315 (1981).

    PubMed  CAS  Google Scholar 

  • Brater, D.C.; Chennavasin, P.; Day, B.; Burdett, A. and Anderson, S.: Bumetanide and furosemide. Clinical Pharmacology and Therapeutics 34: 207–213 (1983a).

    PubMed  CAS  Google Scholar 

  • Brater, D.C.; Day, B.; Anderson, S.A. and Seiwell, R.: Azosemide kinetics and dynamics. Clinical Pharmacology and Therapeutics 34: 454–458 (1983b).

    PubMed  CAS  Google Scholar 

  • Brazier, J.L.; Pozet, N.; Faucon, G.; Traeger, J. and Hadj Aissa, A.: Kinetics of a high dose of piretanide in renal failure. European Journal of Clinical Pharmacology 21: 307–310 (1982).

    PubMed  CAS  Google Scholar 

  • Brazy, P.C. and Gunn, R.B.: Furosemide inhibition of chloride transport in human red blood cells. Journal of General Physiology 68: 583–599 (1976).

    PubMed  CAS  Google Scholar 

  • Brogden, R.N.; Speight, T.M. and Avery, G.S.: Mefruside: A preliminary report of its pharmacological properties and therapeutic efficacy in oedema and hypertension. Drugs 7: 419–425 (1974).

    PubMed  CAS  Google Scholar 

  • Brogden, R.N.; Speight, T.M. and Avery, G.S.: Bumetanide: A preliminary report of its pharmacological properties and therapeutic efficacy in oedema. Drugs 9: 4–18 (1975).

    PubMed  CAS  Google Scholar 

  • Brooks, B.A. and Lant, A.F.: The use of the human erythrocyte as a model for studying the action of diuretics on sodium and chloride transport. Clinical Science and Molecular Medicine 54: 679–683 (1978).

    PubMed  CAS  Google Scholar 

  • Brooks, B.A.; Blair, E.M.; Finch, R. and Lant, A.F.: Studies on the mechanism and characteristics of action of a uricosuric diuretic, indacrinone (MK-196). British Journal of Clinical Pharmacology 10: 249–258 (1980).

    PubMed  CAS  Google Scholar 

  • Brooks, B.A.; Lant, A.F.; McNabb, W.J. and Noormohamed, F.H.: Stereo-specificity of diuretic receptors in the nephron — a study of the enantiomers of indacrinone (MK196) in man. Renal Physiology 7: 304–310 (1984b).

    PubMed  CAS  Google Scholar 

  • Brooks, B.A.; Lant, A.F.; McNabb, W.R. and Noormohamed, F.H.: Renal actions of uricosuric diuretic, racemic indacrinone, in man: Comparison with ethacrynic acid and hydrochlorothiazide. British Journal of Clinical Pharmacology 17: 497–512 (1984a).

    PubMed  CAS  Google Scholar 

  • Brors, O.; Jacobsen, S. and Arnesen, E.: Pharmacokinetics of a single oral dose of muzolimine in cardiac failure. European Journal of Clinical Pharmacology 14: 29–37 (1978).

    PubMed  CAS  Google Scholar 

  • Brors, O.; Jacobsen, S. and Arnesen, E.: Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure. European Journal of Clinical Pharmacology 15: 105–108 (1979).

    PubMed  CAS  Google Scholar 

  • Burke, T.J. and Duchin, K.: Glomerular filtration during furosemide diuresis in the dog. Kidney International 16: 672–680 (1979).

    PubMed  CAS  Google Scholar 

  • Burg, M.B.: Tubular chloride transport and the mode of the action of some diuretics. Kidney International 9: 189–197 (1976).

    PubMed  CAS  Google Scholar 

  • Burg, M.B. and Green, N.: Function of the thick ascending limb of Henle’s Loop. American Journal of Physiology 224: 659–669 (1973).

    PubMed  CAS  Google Scholar 

  • Burg, M.; Stoner, L.; Cardinal, J. and Green, N.: Furosemide effect on isolated perfused tubules. American Journal of Physiology 225: 119–124 (1973).

    PubMed  CAS  Google Scholar 

  • Campbell, D.B. and Moore, R.A.: The pharmacology and clinical pharmacology of indapamide. Postgraduate Medical Journal 57 (Suppl. 2): 7–17 (1981).

    PubMed  CAS  Google Scholar 

  • Campbell, D.B.; Taylor, A.R.; Hopkins, Y.W. and Williams, J.R.B.: Pharmacokinetics and metabolism of indapamide: A review. Current Medical Research and Opinion 5 (Suppl. 1): 13–24 (1977).

    CAS  Google Scholar 

  • Candia, O.A.: The active translocation of Cl and Na by the frog corneal epithelium: Cotransport or separate pumps; in Zadunaisky (Ed.) Chloride Transport in Biological Membranes, pp.223–242 (Academic Press, New York 1982).

    Google Scholar 

  • Chaffman, M.; Heel, R.C.; Brogden, R.N.; Speight, T.M. and Avery, G.S.: Indapamide: A review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs 28: 189–235 (1984).

    PubMed  CAS  Google Scholar 

  • Chennavasin, P.; Seiwell, R.; Brater, D.C. and Liang, W.M.M.: Pharmacodynamic analysis of the furosemide-probenecid interaction in man. Kidney International 16: 187–195 (1979).

    PubMed  CAS  Google Scholar 

  • Chennavasin, P.; Seiwell, R. and Brater, D.C.: Pharmacokineticdynamic analysis of the indomethacin-furosemide interaction in man. Journal of Pharmacology and Experimental Therapeutics 215: 77–81 (1980).

    PubMed  CAS  Google Scholar 

  • Chonko, A.M.; Bay, W.H.; Stein, J.H. and Ferris, T.F.: The role of renin and aldosterone in the salt retention of edema. American Journal of Medicine 63: 881–889 (1977).

    PubMed  CAS  Google Scholar 

  • Cinotti, G.A.: Interactions of renin, kinins and prostaglandins. Journal of Hypertension 1 (Suppl. 1): 43–51 (1983).

    PubMed  CAS  Google Scholar 

  • Cragoe, E.J.: Structure-activity relationship in the amiloride series; in Cuthbert et al. (Eds) Amiloride and Epithelial Sodium Transport, pp. 1–20 (Urban and Schwarzenberg, Baltimore, 1979).

    Google Scholar 

  • Cragoe, E.J. (Ed.): Diuretic Agents. ACS Symposium Series No. 83 (American Chemical Society, Washington 1978).

    Google Scholar 

  • Cragoe, E.J. (Ed.): Diuretics. Chemistry, Pharmacology, and Medicine (John Wiley and Sons, New York 1983a).

  • Craven, P.A. and DeRubertis, F.R.: Calcium-dependent stimulation of renal medullary prostaglandin synthesis by furosemide. Journal of Pharmacology and Experimental Therapeutics 222: 306–314 (1982).

    PubMed  CAS  Google Scholar 

  • Cunarro, J.A. and Weiner, M.W.: Effects of ethacrynic acid and furosemide on respiration of isolated kidney tubules: The role of ion transport and the source of metabolic energy. Journal of Pharmacology and Experimental Therapeutics 206: 198–206 (1978).

    PubMed  CAS  Google Scholar 

  • Cutler, R.E. and Blair, A.D.: Clinical pharmacokinetics of frusemide. Clinical Pharmacokinetics 4: 279–296 (1979).

    PubMed  CAS  Google Scholar 

  • Dal Canton, A.; Russo, D.; Gallo, R.; Conte, G. and Andreucci, V.E.: Muzolimine: A new high-ceiling diuretic suitable for patients with advanced renal disease. British Medical Journal 282: 595–598 (1981).

    Google Scholar 

  • Dargie, H.J.; Boddy, K.; Kennedy, A.C.; King, P.C.; Read, P.R. and Ward, D.M.: Total body potassium in long-term frusemide therapy: Is potassium supplementation necessary? British Medical Journal 4: 316–319 (1974).

    PubMed  CAS  Google Scholar 

  • Dargie, H.J.; Allison, M.E.M.; Kennedy, A.C. and Gray, M.J.B.: High dose metolazone in chronic renal failure. British Medical Journal 4: 196–198 (1972).

    PubMed  CAS  Google Scholar 

  • Data, J.L.; Rane, A.; Gerkens, J.; Wilkinson, G.R.; Nies, A.S. and Branch, R.A.: The influence of indomethacin on the pharmacokinetics, diuretic response and hemodynamics of furosemide in the dog. Journal of Pharmacology and Experimental Therapeutics 206: 431–438 (1978).

    PubMed  CAS  Google Scholar 

  • Davies, D.L.; Lant, A.F.; Millard, N.R.; Smith, A.J.; Ward, J.W. and Wilson, G.M.: Renal action, therapeutic use, and pharmacokinetics of the diuretic bumetanide. Clinical Pharmacology and therapeutics 15: 141–155 (1974).

    PubMed  CAS  Google Scholar 

  • Davies, D.L. and Wilson, G.M.: Diuretics: Mechanism of action and clinical application. Drugs 9: 178–226 (1975).

    PubMed  CAS  Google Scholar 

  • De Wardener, H.E.: Natriuretic hormone. Clinical Science 52: 1–8 (1977).

    Google Scholar 

  • De Wardener, H.E. and Clarkson, E.M.: The natriuretic hormone: Recent developments. Clinical Science 63: 415–420 (1982).

    PubMed  Google Scholar 

  • DiBona, G.F.: Neural control of renal tubular sodium reabsorption. American Journal of Physiology 233: F73–F81 (1977).

    PubMed  CAS  Google Scholar 

  • Dieterle, W.; Wagner, J. and Faigle, J.W.: Binding of chlorthalidone (Hygroton) to blood components in man. European Journal of Clinical Pharmacology 10: 37–42 (1976).

    CAS  Google Scholar 

  • Dixon, W.R.; Young, R.L.; Holazo, A.; Jack, M.L.; Weinfeld, R.E.; Alexander, K.; Liebman, A. and Kaplan, S.A.: Bumetanide: Radioimmunoassay and pharmacokinetic profile in humans. Journal of Pharmaceutical Sciences 65: 701–704 (1976).

    PubMed  CAS  Google Scholar 

  • Duchin, K.L. and Hutcheon, D.E.: Distribution of intracortical renal blood flow induced by bumetanide in the dog. Journal of Pharmacology and Experimental Therapeutics 204: 135–140 (1978).

    PubMed  CAS  Google Scholar 

  • Dunham, P.D.; Stewart, G.W. and Ellory, J.C.: Chloride-activated passive potassium transport in human erythrocytes. Proceedings of the National Academy of Science 77: 1711–1715 (1980).

    CAS  Google Scholar 

  • Dunn, M.J.: Ouabain-uninhibited sodium transport in human erythrocytes. Journal of Clinical Investigation 52: 658–670 (1973).

    PubMed  CAS  Google Scholar 

  • Dunn, M.J. and Hood, V.L.: Prostaglandins and the kidney. American Journal of Physiology 233: F169–F184 (1977).

    CAS  Google Scholar 

  • Dunn, M.J. and Zambraski, E.J.: Renal effects of drugs that inhibit prostaglandins synthesis. Kidney International 18: 609–622 (1980).

    PubMed  CAS  Google Scholar 

  • Dyckner, T. and Wester, P.O.: Intracellular magnesium loss after diuretic administration. Drugs 28 (Suppl. 1): 161–166 (1984).

    PubMed  CAS  Google Scholar 

  • Eide, I.; Loyning, E.; Langard, O. and Kill, F.: Influence of ethacrynic acid on intrarenal renin release mechanisms. Kidney International 8: 158–165 (1975).

    PubMed  CAS  Google Scholar 

  • Eigler, J.; Kelter, J. and Renner, E.: Wirkungscharacteristika eines neuen Acylguanidins-Amilorid-HC1 (MK-870) an der isolierten Haut von Amphibien. Klinische Wochenschrift 14: 737–738 (1967).

    Google Scholar 

  • Eknoyan, G.; Sawa, H.; Hyde III, S.; Wood, J.M.; Schwartz, A. and Suki, W.: Effects of diuretics on oxidative phosphorylation of dog kidney mitochondria. Journal of Pharmacology and Experimental Therapeutics 194: 614–623 (1975).

    PubMed  CAS  Google Scholar 

  • Ellory, J.C. and Stewart, G.W.: The human erythrocyte CL-de-pendent Na-K cotransport system as a possible model for studying the action of loop diuretics. British Journal of Pharmacology 75: 183–188 (1982).

    PubMed  CAS  Google Scholar 

  • Epstein, F.H.: Role of sodium-potassium-ATPase in sodium reabsorption by the kidney; in Lant and Wilson (Eds) Modern Diuretic Therapy in the Treatment of Cardiovascular and Renal Disease, pp. 188–193 (Excerpta Medica, Amsterdam 1973).

    Google Scholar 

  • Eveloff, J.; Bayerdorffer, E.; Silva, P. and Kinne, R.: Sodium-chloride transport in the thick ascending limb of Henle’s loop. Pflugers Archiv 389: 263–270 (1981).

    PubMed  CAS  Google Scholar 

  • Eveloff, J. and Kinne, R.: Sodium-chloride transport in the medullary thick ascending limb of Henle’s loop: Evidence of a sodium-chloride co-transport system in plasma membrane vesicles. Journal of Membrane Biology 72: 173–181 (1983).

    PubMed  CAS  Google Scholar 

  • Fanelli Jr, G.M.; Bohn, D.L.; Scriabine, A. and Beyer Jr, D.H.: Saluretic and uricosuric effects of (6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxy) acetic acid (MK-196) in the chimpanzee. Journal of Pharmacology and Experimental Therapeutics 200: 402–412 (1977a).

    PubMed  CAS  Google Scholar 

  • Fanelli Jr, G.M.; Bohn, D.L. and Zacchei, A.G.: Renal excretion of saluretic-uricosuric agent (MK-196) and interaction with a urate retaining drug, pyrazinoate, in the chimpanzee. Journal of Pharmacology and Experimental Therapeutics 200: 413–419 (1977b).

    PubMed  CAS  Google Scholar 

  • Favre, L.; Glasson, P.H.; Riondel, A. and Vallotton, B.: Interaction of diuretics and non-steroidal anti-inflammatory drugs in man. Clinical Science 54: 407–415 (1983).

    Google Scholar 

  • Feit, P.W.: Aminobenzoic acid diuretics 2. 4-substituted-3-amino-5-sulfamylbenzoic acid derivatives. Journal of Medicinal Chemistry 14: 423–439 (1971).

    Google Scholar 

  • Feit, P.W.: Structure-activity relationships of sulphamoyl diuretics. Postgraduate Medical Journal 51: 9–13 (1975).

    PubMed  CAS  Google Scholar 

  • Feit, P.W.: Diuretics: Encyclopedia of Chemical Technology, vol. 8, 3rd ed, pp. 1–33 (John Wiley, New York 1979).

    Google Scholar 

  • Feris, E.D.: Salt in hypertension and the effects of diuretics. Annual Review of Pharmacology and Toxicology 19: 13–23 (1979).

    Google Scholar 

  • Fernandez, P. and Puschett, J.B.: Proximal tubular actions of metolazone and chlorothiazide. American Journal of Physiology 225: 945–961 (1973).

    Google Scholar 

  • Fine, L.G. and Kirschenbaum, M.A.: Absence of direct effects of prostaglandins on sodium chloride transport in the mammalian nephron. Kidney International 19: 797–801 (1981).

    PubMed  CAS  Google Scholar 

  • Fleuren, H.L.J. and Van Rossum, J.M.: Determination of chlorthalidone in plasma, urine and red blood cells by gas chromatography with nitrogen detection. Journal of Chromatography 152: 41–54 (1978).

    PubMed  CAS  Google Scholar 

  • Fleuren, H.L.J.; Van-Verwey Wissen, C.P.W, and Van Rossum, J.M.: Quantitative gas Chromatographie determination of two oxidized metabolites of the diuretic mefruside in human urine, plasma and red blood cells. Journal of Chromatography 182: 179–190 (1980).

    PubMed  CAS  Google Scholar 

  • Frazier, H.S. and Yager, H.: The clinical use of diuretics (first of two parts). New England Journal of Medicine 288: 246–249 (1973a).

    PubMed  CAS  Google Scholar 

  • Frazier, H.S. and Yager, H.: The clinical use of diuretics (second of two parts). New England Journal of Medicine 288: 455–457 (1973a).

    PubMed  CAS  Google Scholar 

  • Freeman, R.H.; Davis, J.P. and Villarreal, D.: Role of renal prostaglandins in the control of renin release. Circulation Research 54: 1–9 (1984).

    PubMed  CAS  Google Scholar 

  • Friedman, P.A. and Roch-Ramel, F.: Hemodynamic and natriuretic effects of bumetanide and furosemide in the cat. Journal of Pharmacology and Experimental Therapeutics 203: 82–91 (1977).

    PubMed  CAS  Google Scholar 

  • Frizzell, R.A.; Field, M. and Schultz, S.: Sodium-coupled chloride transport by epithelial tissue. American Journal of Physiology 236: F1–F8 (1979).

    PubMed  CAS  Google Scholar 

  • Frizzell, R.A., Koch, M.J. and Schultz, S.G.: Ion transport by rabbit colon, I. Active and passive components. Journal of Membrane Biology 27: 297–316 (1976).

    PubMed  CAS  Google Scholar 

  • Gerber, J.G.: Role of prostaglandins in the hemodynamic and tubular effects of furosemide. Federation Proceedings 42: 1707–1710 (1983).

    PubMed  CAS  Google Scholar 

  • Gerber, J.G.; Nies, A.S. and Olson, R.D.: Control of canine renin release: Macula densa requires prostaglandin synthesis. Journal of Physiology 319: 419–429 (1981a).

    PubMed  CAS  Google Scholar 

  • Gerber, J.G.; Olson, R.D. and Nies, A.S.: Interrelationship between proslaglandins and renin release. Kidney International 19: 816–821 (1981b).

    PubMed  CAS  Google Scholar 

  • Gold, C.H. and Viljoen, M.: Site of renal action of xipamide. Clinical Pharmacology and Therapeutics 25: 522–527 (1979).

    PubMed  CAS  Google Scholar 

  • Goldberg, M.: The renal physiology of diuretics; in Handbook of Physiology, Section 8: Renal Physiology, pp. 1003–1031 (American Physiological Society, 1973).

    Google Scholar 

  • Goldberg, M.; Beck, L.H.; Puschett, J.B. and Schubert, J.J.: Sites of action of benzothiadiazines, frusemide and ethacrynic acid; in Lant and Wilson (Eds) Modern Diuretic Therapy in the Treatment of Cardiovascular and Renal Disease pp. 135–144 (Excerpta Medica, Amsterdam 1973).

    Google Scholar 

  • Goldberg, M.; McCurdy, D.K.; Foltz, E.L. and Bluemle, L.W.: Effects of ethacrynic acid (a new saluretic agent) on renal diluting and concentrating mechanisms. Evidence for site of action in the loop of Henle. Journal of Clinical Investigation 43: 201–216 (1964).

    PubMed  CAS  Google Scholar 

  • Grebow, P.E.; Treitman, J.A.; Barry, E.P.; Blasucci, D.J.; Portelli, S.T.; Tantillo, N.C.; Vukovich, R.A. and Neiss, E.S.: Pharmacokinetics and bioavailability of indapamide — a new antihypertensive drug. European Journal of Clinical Pharmacology 22: 295–299 (1982).

    PubMed  CAS  Google Scholar 

  • Greger, R.: Chloride reabsorption in the rabbit cortical thick ascending limb of the loop of Henle. Pflügers Archiv 390: 38–43 (1981).

    PubMed  CAS  Google Scholar 

  • Greger, R. and Schlatter, E.: Properties of the lumen membrane of the cortical thick ascending limb of Henle’s loop of rabbit kidney. Pflügers Archiv 396: 315–324 (1983a).

    PubMed  CAS  Google Scholar 

  • Greger, R. and Schlatter, E.: Properties of the lumen membrane of the cortical thick ascending limb of Henle’s loop of rabbit kidney. Pflügers Archiv 396: 325–334 (1983b).

    PubMed  CAS  Google Scholar 

  • Greger, R.; Schlatter, E. and Lang, F.: Evidence of electroneutral sodium chloride cotransport in the cortical thick ascending limb of Henle’s loop of rabbit kidney. Pflügers Archiv 396: 308–314 (1983).

    PubMed  CAS  Google Scholar 

  • Greven, J.: Studies on the renal receptors of loop diuretics. Clinical and Experimental Hypertension A5(2): 193–208 (1983).

    CAS  Google Scholar 

  • Greven, J.; Beckers, M.; Defrain, W.; Meywald, K. and Heidenreich, O.: Studies with the optically active isomers of the new diuretic drug ozolinone. Pflügers Archiv 384: 61–64 (1980a).

    PubMed  CAS  Google Scholar 

  • Greven, J.; Defrain, W.; Glaser, K.; Meywald, K. and Heidenreich, O.: Studies with optically active isomers of the new diuretic drug ozolinone. Pflügers Archiv 384: 57–60 (1980b).

    PubMed  CAS  Google Scholar 

  • Gross, P.A.; Schrier, R.W. and Anderson, R.J.: Prostaglandins and water metabolism: A review with emphasis on in vivo studies. Kidney International 19: 839–850 (1981).

    PubMed  CAS  Google Scholar 

  • Haberle and Von Baeyer, H.: Characteristics of glomerulotubular balance. American Journal of Physiology 244: F355–F366 (1983).

    PubMed  CAS  Google Scholar 

  • Hadj Aissa, A.; Pozet, N.; Labeeuw, M.; Pellet, M. and Traeger, J.: Acute effect of a high dose (48mg) of piretanide in advanced renal insufficiency. British Journal of Pharmacology 11: 63–68 (1981).

    CAS  Google Scholar 

  • Halladay, S.C.; Carter, D.E. and Sipes, I.G.: A relationship between the metabolism of bumetanide and its diuretic activity ir. the rat. Drug Metabolism and Disposition 6: 45–49 (1978).

    PubMed  CAS  Google Scholar 

  • Halladay, S.C.; Sipes, I.G. and Carter, D.E.: Diuretic effect and metabolism of bumetanide in man: Clinical Pharmacology and Therapeutics 22: 179–187 (1977).

    Google Scholar 

  • Handler, J.S.: Vasopressin-prostaglandin interactions in the regulation of epithelial cell permeability to water. Kidney International 19: 831–838 (1981).

    PubMed  CAS  Google Scholar 

  • Hebert, S.C. and Andreoli, T.E.: Control of NaCl transport in the thick ascending iimb. American Journal of Physiology 246: F745–F756 (1984).

    PubMed  CAS  Google Scholar 

  • Hempelmann, F.W. and Dieker, P.: Untersuchungen mit xipamid [4-chlor-5-sulfamoyl-2′,6′-salicyloxylidid]. Teil II. pharmacokinetik beim Menschen. Arzneimittel-Forschung 27: 2143–2151 (1977).

    PubMed  CAS  Google Scholar 

  • Henrich, W.L.: Role of prostaglandins in renin secretion. Kidney International 19: 822–830 (1981).

    PubMed  CAS  Google Scholar 

  • Higashio, T.: Abe, Y. and Yamamoto, K.: Renal effects of bumetanide. Journal of Pharmacology and Experimental Therapeutics 207: 212–220 (1978).

    PubMed  CAS  Google Scholar 

  • Hinsvark, O.N.; Zazulak, W. and Cohen, A.I.: Liquid chromatography: Its use in the biological characterization and study of metolazone — a new diuretic. Journal of Chromatographie Science 10: 379–383 (1972).

    CAS  Google Scholar 

  • Hobbs, D.C. and Twomey, T.M.: Kinetics of polythiazide. Clinical Pharmacology and Therapeutics 23: 241–246 (1978).

    PubMed  CAS  Google Scholar 

  • Hoffman, E.K.: Anion exchange and anion-cation co-transport systems in mammalian cells. Philosphical Transactions of the Royal Society of London, Series B 299: 519–535 (1982).

    Google Scholar 

  • Hoffman, J.F. and Kregenow, F.M.: The characterization of new energy dependent cation transport processes in red blood cells. Annals of the New York Academy of Sciences 137: 566–576 (1966).

    PubMed  CAS  Google Scholar 

  • Holland, S.D. and Williamson, H.E.: Probeneid inhibition of bumetanide induced natriuresis in the dog. Proceedings of the Society of Experimental Biology and Medicine 161: 299–302 (1979).

    CAS  Google Scholar 

  • Homeida, M.; Roberts, C. and Branch, R.A.: Influence of probenecid and spironolactone on furosemide kinetics and dynamics in man. Clinical Pharmacology and Therapeutics 22: 402–409 (1977).

    PubMed  CAS  Google Scholar 

  • Honari, J.; Blair, A.D. and Cutler, R.E.: Effects of probenecid on furosemide kinetics and natriuresis in man. Clinical Pharmacology and Therapeutics 22: 395–401 (1977).

    PubMed  CAS  Google Scholar 

  • Horstmann, H.; Cragoe (Ed.); Moller, E.; Wehinger, E. and Meng, K.: l-aralkyl-2-pyrazolin-5-ones: A new class of highly patent diuretics with high ceiling activity; in Diuretic Agents, pp. 125–154 (American Chemical Society, Washington 1978).

    Google Scholar 

  • Hoyer, J.R. and Seiler, M.W.: Pathophysiology of Tamm-Horsfall protein. Kidney International 16: 279–189 (1979).

    PubMed  CAS  Google Scholar 

  • Ichikawa, I. and Brenner, B.M.: Importance of efferent arteriolar vascular tone in regulation of proximal tubule fluid reabsorption and glomerulotubular balance in the rat. Journal of Clinical Investigation 65: 1192–1201 (1980).

    PubMed  CAS  Google Scholar 

  • Ichikawa, I. and Brenner, B.M.: Glomerular actions of angiotensin II. American Journal of Medicine 76(5B): 43–49 (1984).

    PubMed  CAS  Google Scholar 

  • Imai, M.: Effect of bumetanide and furosemide on the thick ascending limb of Henle’s loop of rabbits and rats perfused in vitro. European Journal of Pharmacology 41: 409–416 (1977).

    PubMed  CAS  Google Scholar 

  • Jayakumar, S. and Puschett, J.B.: Study of the sites and mechanisms of action of bumetanide in man. Journal of Pharmacology and Experimental Therapeutics 201: 251–258 (1977).

    PubMed  CAS  Google Scholar 

  • Johnston, G.D.; Nicholls, D.P.; Leahey, W.J. and Finch, M.B.: The effects of captopril on the acute vascular responses to frusemide in man. Clinical Science 65: 359–363 (1983).

    PubMed  CAS  Google Scholar 

  • Karman, K.K.; Vaara, I.; Notstrand, B.; Lovgren, S.; Borell, A.; Fridborg, K. and Petef, M.: Structure and functions of cardiac anhydrase: Comparative studies of sulphonamide binding to human erythrocyte carbonic anhydrases B and C.; in Roberts (Ed.) Drug Action at the Molecular Level, pp.73–91 (Mac-Millan, London 1977).

    Google Scholar 

  • Kaojarern, S.; Day, B. and Brater, D.C.: The time course of delivery of furosemide into urine: An independent determinant of overall response. Kidney International 22: 69–74 (1982).

    PubMed  CAS  Google Scholar 

  • Katz, A.I.: Renal Na-K-ATPase: Its role in tubular sodium and potassium transport. American Journal of Physiology 242: F207–F219 (1982).

    PubMed  CAS  Google Scholar 

  • Kaufman, J.; Hamburger, R.; Matheson, J. and Flamenbaum, W.: Bumetanide-induced diuresis and natriuresis: Effect of prostaglandin synthetase inhibition. Journal of Clinical Pharmacology 21: 663–667 (1981).

    PubMed  CAS  Google Scholar 

  • Kauker, M.L.: Clearance and micropuncture studies of the effects of a new indanyloxyacetic acid diuretic on segmental nephron function in rats. Journal of Pharmacology and Experimental Therapeutics 200: 81–87 (1977).

    PubMed  CAS  Google Scholar 

  • Kempson, S.A.; Kowalski, J.C. and Puschett, J.B.: Direct effect of metolazone on sodium-dependent transport across the renal brush border membrane. Journal of Laboratory and Clinical Medicine 101: 308–316 (1983).

    PubMed  CAS  Google Scholar 

  • Klahr, S.: The effect of diuretics on kidney intermediary metabolism; in Martinez-Maldonado (Ed.) Methods in Pharmacology, Vol. 4A, Renal Pharmacology, pp. 167–197 (Plenum, New York 1976).

    Google Scholar 

  • Koechel, D.A. and Cafruny, E.J.: Thiol adducts of ethacrynic acid: A correlation of the rate of liberation of ethacrynic acid with the onset and magnitude of the diuretic response. Journal of Pharmacology and Experimental Therapeutics 192: 179–194 (1975).

    PubMed  CAS  Google Scholar 

  • Krück, F.; Badlok, W.; Besenfelder, E.; Betzien, G. and Kaufmann, B.: Clinical and pharmacological investigation of the-new saluretic azosemid. European Journal of Clinical Pharmacology 14: 153–161 (1978).

    PubMed  Google Scholar 

  • Kuhn, W. and Ryffel, K.: Herstellung Konzentrierter Losungen ans verdünnten durch blosse Membranewirkung: Ein Modelliversuch zur Function der Niere. Zeitschrift für Physiologische Chemie 276: 145–178 (1942).

    CAS  Google Scholar 

  • Kunau, R.T.; Weller, D.R. and Webb, H.: Clarification of the site of action of chlorothiazide in the rat nephron. Journal of Clinical Investigation 56: 401–407 (1975).

    PubMed  CAS  Google Scholar 

  • Landon, E.J. and Fitzpatrick, D.F.: Ethacrynic acid and kidney cell metabolism. Biochemical Pharmacology 21: 1561–1568 (1972).

    PubMed  CAS  Google Scholar 

  • Lant, A.F.: Effects of bumetanide on cation and anion transport. Postgraduate Medical Journal 51: 35–42 (1975b).

    PubMed  CAS  Google Scholar 

  • Lant, A.F.: Diuretic therapy. Practitioner 219: 519–528 (1977).

    PubMed  CAS  Google Scholar 

  • Lant, A.F.: Modern diuretics and the kidney. Journal of Clinical Pathology 34: 1267–1275 (1981).

    PubMed  CAS  Google Scholar 

  • Lant, A.: Red cell chloride transport in relation to the action of diuretics, in Puschett and Greenberg (Eds) Diuretics: Chemistry, Pharmacology and Clinical Applications, pp. 313–319 (Elsevier, New York 1984).

    Google Scholar 

  • Lant, A.F.; Baba, W.I. and Wilson, G.M.: On the clinical evaluation of diuretics with particular reference to a new phthalimidine diuretic, clorexolone. Clinical Pharmacology and Therapeutics 7: 196–211 (1966).

    PubMed  CAS  Google Scholar 

  • Lant, A.F.; Baba, W.I. and Wilson, G.M.: Localization of action of oral diuretics in the human kidney. Clinical Science 33: 11–27 (1967).

    PubMed  CAS  Google Scholar 

  • Lant, A.F. and Wilson, G.M.: Diuretics; in Black (Ed.) Renal Disease. 3rd ed., pp.655–704 (Blackwell Scientific, Oxford 1972).

    Google Scholar 

  • Laragh, J.H. and Scalcy, J.E.: The renin-angiotensin-aldosterone hormonal system and regulations of sodium potassium, and blood pressure homcostasis; in Orloff and Berliner (Eds) Handbook of Physiology, Section 8, pp.831–908 (American Physiological Society, Washington 1973).

    Google Scholar 

  • Lawrence, J.R.; Ansari, A.F.; Elliott, H.L.; Sumner, D.J.; Brunton, G.F.; Whiting, B. and Whitesmith, R.: Kinetic and dynamic comparison of piretanide and furosemide. Clinical Pharmacology and Therapeutics 23: 558–565 (1978).

    PubMed  CAS  Google Scholar 

  • Lau, H.S.H.; Shih, L.-J. and Smith, D.E.: Effect of probenecid on the dose-response relationship of bumetanide at steady state. Journal of Pharmacology and Experimental Therapeutics 227: 51–54 (1983).

    PubMed  CAS  Google Scholar 

  • Laubie, M. and Schmitt, H.: Comparison of the haemodynamic and autonomie effects of frusemide and indapamide and localization of the natriuretic action of indapamide. Current Medical Research and Opinion 5 (Suppl. 1): 89–100 (1977).

    CAS  Google Scholar 

  • Loew, D. and Meng, K.: The renal mechanism of Bay g2821. Pharma-Therapeutica 1: 333–340 (1977).

    CAS  Google Scholar 

  • Lubowitz, H.: The effect of bumetanide on cation transport in human red blood cells. Journal of Pharmacology and Experimental Therapeutics 203: 92–96 (1977).

    PubMed  CAS  Google Scholar 

  • Lubowitz, H. and Whittam, R.: Ion movements in human red cells independent of the sodium pump. Journal of Physiology 202: 111–131 (1969).

    PubMed  CAS  Google Scholar 

  • Marcantonio, L.A.; Auld, W.H.R.; Murdoch, W.R.; Purohit, R.; Skellern, G.G. and Howes, C.A.: The pharmacokinetics and pharmacodynamics of the diuretic bumetanide in hepatic and renal disease. British Journal of Clinical Pharmacology 15: 245–252 (1983).

    PubMed  CAS  Google Scholar 

  • Mark, K. and Burg, M.: Organization of nephron function. American Journal of Physiology 13: F579–F589 (1983).

    Google Scholar 

  • Martinez-Maldonado, M. and Schwartz, A.: Renal ATPase as a receptor for drugs acting on the kidney; in Martinez-Maldonado (Ed.) Methods of Pharmacology, Vol. 4A, Renal Pharmacology, pp. 199–225 (Plenum, New York 1976).

    Google Scholar 

  • McGiff, J.C.: Interactions of prostaglandins with the kallikreinkinin and renin-angiotensin systems. Clinical Science 59: 105S–116S (1980).

    PubMed  CAS  Google Scholar 

  • McGiff, J.C.; Spokas, E.C. and Y.-K.-Wong, P.: Stimulation of renin release by 6-oxo-prostaglandin E and prostacyclin. British Journal of Pharmacology 75: 137–144 (1982).

    PubMed  CAS  Google Scholar 

  • McNabb, W.R.; Noormohamed, F.H.; Brooks, B.A. and Lant, A.F.: Renal actions of piretanide and three other ‘loop’ diuretics in man. Clinical Pharmacology and Therapeutics 35: 328–337 (1984).

    PubMed  CAS  Google Scholar 

  • McNeil, J.J.; Drummer, O. and Louis, W.J.: Clopamide pharmacokinetics and effects on urinary electrolyte excretion. Clinical and Experimental Pharmacology and Physiology 10: 193–193 (1983).

    Google Scholar 

  • Merkel, W.; Bormann, D.; Mania, D.; Muschaweck, R. and Hropot, M.: Piretanide (HOE-118), a new high ceiling salidiuretic. European Journal of Medicinal Chemistry 11: 399–406 (1976).

    CAS  Google Scholar 

  • Morgan, T.O.: Diuretics: Basic clinical pharmacology and therapeutic use. Drugs 15: 151–158 (1978).

    PubMed  CAS  Google Scholar 

  • Motais, R. and Cousin, J.L.: Inhibitory effect of ethacrynic acid on chloride permeability. American Journal of Physiology 231: 1485–1489 (1976).

    PubMed  CAS  Google Scholar 

  • Mussche, M. and Lameire, N.: The mechanism of action of Bay g2821: A new diuretic. Current Medical Research and Opinion 4: 462–468 (1977).

    PubMed  CAS  Google Scholar 

  • Nascimento, L.; Ayala, J.M; Baquero, R.A. and Martinez-Maldonado, M.: Renin release by diuretics. Journal of Pharmacology and Experimental Therapeutics 208: 522–526 (1979).

    PubMed  CAS  Google Scholar 

  • Nechay, B.R.: Relationship between inhibition of renal Na+ plus K+-ATPase and natriuresis. Annals of the New York Academy of Sciences 242: 501–518 (1974).

    PubMed  CAS  Google Scholar 

  • Nechay, B.R.: Biochemical basis of diuretic action. Journal of Clinical Pharmacology 10: 626–641 (1977).

    Google Scholar 

  • Nielsen, O.B.T. and Feit, P.W.: Structure-activity relationship of aminobenzoic acid diuretics and related compounds; in Cragoe (Ed.) Diuretic Agents, ACS Symposium 83, pp. 12–23 (American Clinical Society, Washington, 1978).

    Google Scholar 

  • Nies, A.S.; Gal, J.; Fadul, S. and Gerber, J.G.: Indomethacinfurosemide interaction: The importance of renal blood flow. Journal of Pharmacology and Experimental Therapeutics 226: 27–32 (1983).

    PubMed  CAS  Google Scholar 

  • Novello, F.C. and Sprague, J.M.: Benzothiadiazine dioxides as novel diuretics. Journal of the American Chemical Society 79: 2028–2029 (1957).

    CAS  Google Scholar 

  • Odlind, B.: Relationship between renal tubular secretion and effects of five loop diuretics. Journal of Pharmacology and Experimental Therapeutics 211: 238–244 (1979a).

    PubMed  CAS  Google Scholar 

  • Odlind, B.: Relationship between tubular secretion of furosemide and its saluretic effect. Journal of Pharmacology and Experimental Therapeutics 208: 515–521 (1979b).

    PubMed  CAS  Google Scholar 

  • Odlind, B.: Determinants of access of diuretics to their site of action. Federation Proceedings 42: 1703–1706 (1983).

    PubMed  CAS  Google Scholar 

  • Odlind, B. and Beermann, B.: Renal tubular secretion and effects of furosemide. Clinical Pharmacology and Therapeutics 27: 784–790 (1980).

    PubMed  CAS  Google Scholar 

  • Odlind, B.; Beermann, B.; Selen, G. and Persson, A.E.G.: Renal tubular secretion of piretanide and its effects on electrolyte reabsorption and tubuloglomerular feedback mechanism. Journal of Pharmacology and Experimental Therapeutics 225: 742–746 (1983).

    PubMed  CAS  Google Scholar 

  • Olsen, U.B.: Indomethacin inhibition of bumetanide diuresis in dog. Acta Pharmacologica et Toxicologica 37: 65–78 (1975).

    PubMed  CAS  Google Scholar 

  • Onesti, G.; Pitone, J.; Lowenthal, D.L.; Kim, K.E.; Affrime, M.; Bronstein, B.J.; Shirk, J.; Valvo, E.; Martinez, E.; Fernandes, M. and Swartz, C.: Studies on the natriuretic effect and site of action of indapamide. Current Medical Research and Opinion 5 (Suppl. 1): 83–88 (1977).

    CAS  Google Scholar 

  • Orloff, J. and Zusman, R.: Role of prostaglandin E (PGE) in the modulation of the action of vasopressin on water flow in the urinary bladder of the toad and mammalian kidney. Journal of Membrane Biology 40: 297–304 (1978).

    PubMed  CAS  Google Scholar 

  • Orsoni, G.; Di Felice, A.; Cucudis, P.; Vangelista, A.; Stefoni, S. and Bonomini, V.: The use of muzolimine in chronic renal failure; in Andreucci (Ed.) Recent Advances in Diuretic Therapy, pp.246–255 (Excerpta Medica, Amsterdam 1983).

    Google Scholar 

  • Østergaard, E.H.; Magnussen, M.P.; Nielsen, C.K.; Eilertsen, E. and Frey, H.H.: Pharmacological properties of 3N-butyl-amino-4-phenoxy-5-sulfamoyl-benzoic acid (bumetanide) a new potent diuretic. Arzneimittel-Forschung 22: 66–72 (1972).

    PubMed  Google Scholar 

  • Palfrey, H.C.; Feit, P.W. and Greengard, P.: cAMP-stimulated cation cotransport in avian erythrocytes: Inhibition by “Loop” diuretics. American Journal of Physiology 238: C139–C148 (1980).

    PubMed  CAS  Google Scholar 

  • Patak, R.V.; Fadem, S.Z.; Rosenblatt, S.G.; Lifschitz, M.D. and Stein, J.H.: Diuretic-induced changes in renal blood flow and prostaglandins E excretion in the dog. American Journal of Physiology 236: F494–F500 (1980).

    Google Scholar 

  • Peach, M.J.: Renin-angiotensin system. Biochemistry and mechanisms of action. Physiological Reviews 57: 313–370 (1977).

    PubMed  CAS  Google Scholar 

  • Pentikainen, P.J.; Penttila, A.; Neuvonen, P.J. and Gothoni, G.: Fate of [l4C]-bumetanide in man. British Journal of Clinical Pharmacology 4: 39–44 (1977).

    PubMed  CAS  Google Scholar 

  • Perez, J.; Sitar, D.S. and Ogilvie, R.I.: Kinetic disposition and diuretic effect of frusemide in acute pulmonary oedema. British Journal of Clinical Pharmacology 9: 471–478 (1980).

    PubMed  CAS  Google Scholar 

  • Pozet, N.; Hadj-Aissa, A. and Pellet, M.: Activity of a new high efficiency diuretic in man: Piretanide (HOE 118). British Journal of Clinical Pharmacology 9: 577–583 (1980).

    PubMed  CAS  Google Scholar 

  • Proudfoot, A.D.; McNeil, J.J.; Drummer, O. and Louis, W.J.: Clopamide pharmacokinetics and effects on urinary electrolyte excretions, (abstract). Clinical and Experimental Pharmacology and Physiology 10: 193 (1983).

    Google Scholar 

  • Pruitt, A.W.; Winkel, J.S. and Dayton, P.G.: Variations in the fate of triamterene. Clinical Pharmacology and Therapeutics 21: 610–619 (1977).

    PubMed  CAS  Google Scholar 

  • Puschett, J.R. and Greenberg, A. (Eds): Diuretics: Chemistry, Pharmacology and Clinical Applications (Elsevier, New York 1984).

    Google Scholar 

  • Puschett, J.B. and Goldberg, M.: The acute effects of furosemide on acid and electrolyte excretion in man. Journal of Laboratory and Clinical Medicine 71: 666–677 (1968).

    PubMed  CAS  Google Scholar 

  • Puschett, J.B.; Steinmuller, S.R.; Rastegar, A. and Fernandez, P.: Metolazone: Mechanisms and sites of action; in Lant and Wilson (Eds) Modern Diuretic Therapy in the Treatment of Cardiovascular and Renal Disease, pp. 168–175 (Excerpta Medica, Amsterdam 1973).

    Google Scholar 

  • Puschett, J.B.; Sylk, D. and Teredesai, P.R.: Uncoupling of proximal sodium bicarbonate from sodium phosphate transport by bumetanide. American Journal of Physiology 235: F403–F408 (1978).

    PubMed  CAS  Google Scholar 

  • Quamme, G.A.: Effect of furosemide on calcium and magnesium transport in the rat nephron. American Journal of Physiology 241: F340–F347 (1981).

    PubMed  CAS  Google Scholar 

  • Rector, F.: Sodium bicarbonate, and chloride absorption by the proximal tubule. American Journal of Physiology 13: F461–F471 (1983).

    Google Scholar 

  • Reiss, W.; Dubach, U.C.; Burckhardt, p.; Theobald, W.; Vuillard, P. and Zimmerli, M.: Pharmacokinetic studies with chlorthalidonc (Hygroton) in man. European Journal of Clinical Pharmacology 12: 375–382 (1977).

    Google Scholar 

  • Ritter, W.: Pharmacokinetics of Bay g2821 in the dog and in man. Current Medical Research and Opinion 4: 564–573 (1977).

    PubMed  CAS  Google Scholar 

  • Ritter, W.: Pharmacokinetics of muzolimine. Clinical Nephrology 19 (Suppl. 1): S26–S31 (1983).

    Google Scholar 

  • Roberts, C.J.C.; Homeida, M. and Roberts, F.: Effects of piretanide, bumetanide and frusemide on electrolyte and urate excretion in normal subjects. British Journal of Clinical Pharmacology 6: 129–133 (1978).

    PubMed  CAS  Google Scholar 

  • Rocha, A.S. and Kokko, J.P.: Sodium chloride and water transport in the medullary thick ascending limb of Henle: Evidence for active chloride transport. Journal of Clinical Investigation 52: 612–623 (1973)

    PubMed  CAS  Google Scholar 

  • Röckel, A.: Diuretic effects of Bay g2821 in patients with advanced renal failure. Current Medical Research and Opinion 4: 574–579 (1977).

    PubMed  Google Scholar 

  • Rothstein, A. and Ramjeesingh, M.: The functional arrangement of the anion channel of red blood cells. Annals of the New York Academy of Sciences 358: 1–12 (1980).

    PubMed  CAS  Google Scholar 

  • Satzinger, G.; Herrmann, M.; Vollmer, K.O.; Merzweiler, A.; Gomahr, H.; Heildenreich, O. and Greven, J.: Etozolin: A novel diuretic; in Cragoe (Ed.) Diuretic Agents pp. 156–189 (American Chemical Society, Washington 1978).

    Google Scholar 

  • Scherer, B. and Weber, P.C.: Time-dependent changes in prostaglandin excretion in response to frusemide in man. Clinical Science 56: 77–81 (1979).

    PubMed  CAS  Google Scholar 

  • Schlatter, E.; Greger, R. and Weidtke, C.: Effect of “high ceiling” diuretics on active salt transport in the cortical thick ascending limb of Henle’s loop of rabbit kidney. Pflugers Archiv 396: 210–217 (1983).

    PubMed  CAS  Google Scholar 

  • Schlondorff, D.; Zanger, R.; Stariano, J.A.; Folkert, V.W. and Eveloff, J.: Prostaglandin synthesis by isolated cells from the outer medulla and from the thick ascending loop of Henle of rabbit kidney. Journal of Pharmacology and Experimental Therapeutics 223: 120–154 (1982).

    PubMed  CAS  Google Scholar 

  • Schmidt, U. and Dubach, U.C.: Activity of Na+-K+-stimulated adenosine triphosphatase in the rat nephron. European Journal of Physiology 306: 219–226 (1969).

    PubMed  CAS  Google Scholar 

  • Schultz, E.M.; Cragoe, E.J.; Bicking, J.B.; Bolhofer, W.A. and Sprague, J.M.: α, β- Un saturated ketone derivatives of aryloxyacetic acids, a new class of diuretics. Journal of Medicinal Chemistry 5: 660–662 (1962).

    CAS  Google Scholar 

  • Scriabinc, A.; Watson, L.S.; Russo, H.F.; Ludden, C.T.; Sweet, C.S.; Fanclli, G.M.; Bohidar, N.R. and Stone, C.A.: Diuretic and antihypertensive effects of 2-aminoethyl-4- (l,l-dimethylcthyl)-6-iodophenol hydrochloride (MK-447). Journal of Pharmacology and Experimental Therapeutics 208: 148–154 (1979).

    Google Scholar 

  • Scely, J.F. and Dirks, J.H.: Site of action of diuretic drugs. Kidney International 11: 1–8 (1977).

    Google Scholar 

  • Scldin, D.W.: Diuretic-induced potassium loss; in Andreucci (Ed.) Recent Advances in Diuretic Therapy, pp.9–20 (Excerpta Medica, Amsterdam 1982).

    Google Scholar 

  • Shideman, J.R.; Zmuda, M.J. and Quebbemann, A.J.: The acute effects of furoscmide, ethacrynic acid and chlorothiazide on the renal tubular handling of uric acid in the chicken. Journal of Pharmacology and Experimental Therapeutics 216: 441–446 (1981).

    PubMed  CAS  Google Scholar 

  • Skorecki, K.L. and Brenner, B.M.: Body fluid homeostasis in congestive heart failure and cirrhosis with ascites. American Journal of Medicine 22: 323–338 (1982).

    Google Scholar 

  • Smith, R.L.; Schultz, E.M.; Stokker, G.E. and Cragoe Jr, E.J.: 2-Amino-methylphenols: A new class of saluretic agents; in Cragoc (Ed) Diuretic Agents, pp.93–124 (American Chemical Society, Washington 1978).

    Google Scholar 

  • Sperber, I.: A new method for the study of renal tubular excretion in birds. Nature (London) 158: 131 (1946).

    CAS  Google Scholar 

  • Stokes, J.B.: Potassium secretion by cortical collecting tubule: Relation to sodium absorption, luminal sodium concentration and transepithelial voltage. American Journal of Physiology 241: F395–F402 (1981).

    PubMed  CAS  Google Scholar 

  • Stone, K.J. and Hart, M.: Inhibition of renal PGE2-9-keto-reductase by diuretics. Prostaglandins 12: 197–207 (1976).

    PubMed  CAS  Google Scholar 

  • Sturm, K.; Siedel, W.; Weyer, R. and Ruschig, H.: Zur Chemie des Furosemids, I. Synthesen von 5-sulfamoyl-anthranilsaure-Derivaten. Chemische Berichte 99: 328–344 (1966).

    CAS  Google Scholar 

  • Suki, W.; Rector, F.C. and Seldin, D.W.: The site of action of furosemide and other sulfonamide diuretics in the dog. Journal of Clinical Investigations 44: 1458–1469 (1965).

    CAS  Google Scholar 

  • Teredesai, P. and Puschett, B.: Acute effects of piretanide in normal subjects. Clinical Pharmacology and Therapeutics 25: 331–339 (1979).

    PubMed  CAS  Google Scholar 

  • Tilstone, W.J. and Fine, A.: Furosemide kinetics in renal failure. Clinical Pharmacology and Therapeutics 23: 644–650 (1978).

    PubMed  CAS  Google Scholar 

  • Torretti, J.: Sympathetic control of renin release. Annual Review of Pharmacology and Toxicology 22: 167–192 (1982).

    PubMed  CAS  Google Scholar 

  • Valette, H.; Hebert, J.L.; Raffestin, B.; Lockhart, A. and Apoil, E.: Comparison of hemodynamic effects of furosemide and piretanide in normovolemic patients. Journal of Cardiovascular Pharmacology 2: 103–111 (1980).

    PubMed  CAS  Google Scholar 

  • Valtin, H.: Structural and functional heterogeneity of mammalian nephrons. American Journal of Physiology 233: F491–F501 (1977).

    PubMed  CAS  Google Scholar 

  • Velasquez, M.T.; Han Wan, S. and Marotnde, R.F.: Bumetanide-induced rise in plasma renin activity. Clinical Pharmacology and Therapeutics 24: 186–191 (1978).

    PubMed  CAS  Google Scholar 

  • Velasquez, M.T.; Han Wan, S.; Barr, J.W. and Maronde, R.F.: Effect of probenecid on the natriuresis and renin release induced by bumetanide in man. Journal of Clinical Pharmacology 21: 657–662 (1981).

    PubMed  CAS  Google Scholar 

  • Vose, C.W.; Stevens, P.M.; Murihead, D.C.; Palmer, R.F. and Mclnnes, G.T.: A fluorimetric assay for metolazone in urine. British Journal of Clinical Pharmacology 9: 213–215 (1980).

    PubMed  CAS  Google Scholar 

  • Wade, J.B.; Stetson, D.L. and Lewis, S.A.: ADH action: Evidence for a membrane shuttle mechanism. Annals of the New York Academy of Sciences 372: 106–117 (1981).

    PubMed  CAS  Google Scholar 

  • Ward, A. et al.: Bumetanide: A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use. Drugs 28: 426–464 (1984).

    PubMed  CAS  Google Scholar 

  • Weber, P.C.; Scherer, B. and Larsson, C.: Increase of free arachidonic acid by furosemide in man as the cause of prostaglandins and renin release. European Journal of Pharmacology 41: 329–332 (1977).

    PubMed  CAS  Google Scholar 

  • Weinman, E.J.; Knight, T.F.; McKenzie, R. and Eknoyan, G.: Dissociation of urate from sodium transport in the rat proximal tubule. Kidney International 10: 295–300 (1976).

    PubMed  CAS  Google Scholar 

  • Weinman, E.J.; Senekjian, H.O. and Knight, T.F.: Effects of MK-196 on urate and electrolyte excretion in the rat. Nephron 23 (Suppl. 1): 21–24 (1979).

    PubMed  CAS  Google Scholar 

  • Wiley, J.S. and Cooper, R.A.: A furosemide-sensitive cotransport of sodium plus potassium in the human red cell. Journal of Clinical Investigation 53: 745–755 (1974).

    PubMed  CAS  Google Scholar 

  • Williamson, H.E.; Bourland, W.A. and Marchand, G.R.: Inhibition of furosemide induced increase in renal blood flow by indomethacin. Proceedings of the Society for Experimental Biology and Medicine 148: 164–167 (1975).

    CAS  Google Scholar 

  • Wilson, C.B. and Kirkendall, M.: The acute effects of mefruside in man: A new diuretic compound. Journal of Pharmacology and Experimental Therapeutics 171: 288–299 (1970).

    PubMed  CAS  Google Scholar 

  • Winaver, J.; Sylk, D.B.; Teredesai, P.R.; Robertson, J.S. and Puschett, J.B.: Dissociative effects of piretanide on proximal tubular PO4 and HCO3 transport. American Journal of Physiology 238: F60–F68 (1980).

    PubMed  CAS  Google Scholar 

  • Windhager, E.E. and Giebisch, G.: Proximal sodium and fluid transport. Kidney International 9: 121–133 (1976).

    PubMed  CAS  Google Scholar 

  • Wirth, K.E.; Frolich, J.C.; Hollifield, J.W.; Falkner, F.C.; Sweetman, B.S. and Oates, J.A.: Metabolism of digitoxin in man and its modification by spironolactone. European Journal of Pharmacology 9: 345–354 (1976).

    CAS  Google Scholar 

  • Wirz, H.; Hargitay, B. and Kuhn, W.: Lokalisation des Konzentrierungsprozesses in der Niere durch direkte Kryoscopie. Helvetica Physiologica et Pharmacologica Acta 9: 196–207 (1951).

    PubMed  CAS  Google Scholar 

  • Wright, F.S.: Intrarenal regulation of glomerular filtration rate. New England Journal of Medicine 291: 135–141 (1974).

    PubMed  CAS  Google Scholar 

  • Wright, F.S.: Sites and mechanisms of potassium transport along the renal tubule. Kidney International 11: 415–432 (1977).

    PubMed  CAS  Google Scholar 

  • Wright, F.S. and Briggs, J.P.: Feedback control of glomerular blood flow, pressure and filtration rate. Physiological Reviews 59: 958–1006 (1979).

    PubMed  CAS  Google Scholar 

  • Woltersdorf Jr, O.W.; De Solms, S.J. and Cragoe Jr, E.J.: The evolution of the (aryloxy) acetic acid diuretics; in Cragoe (Ed.) Diuretic Agents, ACS Symposium 83, pp. 190–230 (American Chemical Society, Washington 1978).

    Google Scholar 

  • Yoshida, A.; Yamada, T. and Koshikawa, S.: Effect of diuretic on energy metabolism. Biochemical Pharmacology 20: 1933–1942 (1971).

    PubMed  CAS  Google Scholar 

  • Zacchei, A.G. and Wishousky, T.I.: The physiological disposition of the uricosuric saluretic agent (6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxylacetic acid (MK-196) in the rat, dog and monkey. Drug Metabolism and Disposition 4: 490–498 (1976).

    PubMed  CAS  Google Scholar 

  • Zadunaisky, J.A.: Sodium activation of chloride transport in the frog cornea. Biochemica Biophysica Acta 282: 255–257 (1972).

    CAS  Google Scholar 

  • Zanchetti, A.; Stella, A.; Leonetti, G.; Morganti, A. and Terzoli, L.: Control of renin release: A review of experimental evidence and clinical implications. American Journal of Cardiology 37: 675–691 (1976).

    PubMed  CAS  Google Scholar 

  • Zeuthen, T.; Ramos, M. and Ellory, J.C.: Inhibition of active chloride transport by piretanide. Nature 273: 678–680 (1978).

    PubMed  CAS  Google Scholar 

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  1. Department of Clinical Pharmacology and Therapeutics, Charing Cross and Westminster Medical School, Page Street Wing, London, SW1 2AP, England

    Ariel Lant

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First of two parts. Part II will appear in the following issue.

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Lant, A. Diuretics. Drugs 29, 57–87 (1985). https://doi.org/10.2165/00003495-198529010-00003

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