Summary
To assess haemodynamic effects of short and long term amiodarone on ischaemiainduced left ventricular dysfunction and to compare them with those of glyceryl trinitrate (nitroglycerin), β-blocking and calcium antagonist drugs, 19 patients with chronic ischaemic heart disease were studied, All patients underwent simultaneous right heart catheterisation and equilibrium radionuclide angiocardiography at rest and during symptomlimited supine bicycle exercise, After control measurements without antianginal therapy, 10 patients received 7,5 mg/kg amiodarone intravenously over 5 minutes (short term study) followed by oral administration of amiodarone for 3 weeks (long term study), The remaining 9 patients were studied following the randomised administration of glyceryl trinitrate (0,8mg sublingually), metoprolol (0,15 mg/kg intravenously) and nifedipine (5 ng/kg/min)
During exercise known to provoke angina pectoris without therapy (control study), amiodarone improved myocardial oxygen consumption by reducing heart rate and systolic blood pressure without the negative inotropic effects seen after acute β-adrenoceplor blockade, Comparisons with the haemodynamic profiles of other antianginal drugs suggest that amiodarone may be most effective when combined with glyceryl trinitrate or nifedipine for the treatment of ischaemic left ventricular dysfunction
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References
Charlier, R,; Deltour G, and Baudine A,: Rercherche dans la série des benzofuranes 27, Antagonisme de l’amiodarone visà-vis de certains effets cardiovasculaires et métaboliques des catecholamines chez le chien, Archives Internationales de Physiologie et de Biochimie: 75: 82–86 (1967)
Charlier, R,; Deltour G,; Baudine A, and Chaillet F,: Pharmacology of amiodarone, an anti-anginal drug with a new biological profile, Arzneimittel Forschung 18: 1408–1417 (1968)
Charlier R,; Delaunois G, and Bauthier J,: Caractéristique et méchanisme de l’action de l’amiodarone sur le débit cardiaque et systolique chez le chien, Arzneimittel Forschung 22: 1698–1708 (1972)
Coté P,; Bourassa M,G,; Delaye J,; Janin A,; Froment R, and David P,: Effects of amiodarone on cardiac and coronary hemodynamics and on myoardial metabolism in patients with coronary artery disease, Circulation 59: 1165–1172 (1979)
Moret, P,R,; Boufas D, and Fournet P,C,: Propriétés pharmacologiques d’un nouvel anti-angoreux: l’Amiodarone, Schweizerische Medizinische Wochenschrift 90: 1090–1097 (1969)
Ourback P,; Rocher R,; Aziza J,P,; Manin J,P,; Vagner D,; Leclerc M, and Maurice P,: Effets hémodynamiques de l’injection intraveineuse de chlorhydrate d’amiodarone chez le sujet normal et le coronarien, Archives des Maladies du Coeur et des Vaisseaux 69: 293–302 (1976)
Pfisterer M,; Ricci D,R,; Schuler G,; Swanson S,S,; Gordon, D,G,; Peterson K,L, and Ashburn W,L,: Validity of left ventricular ejection fractions measured at rest and peak exercise by equilibrium radionuclide angiography using short acquisition times, Journal of Nuclear Medicine 20: 484–490 (1979a)
Pfisterer, M,; Battler A,; Swanson S,M,; Slutsky R,; Froelicher V, and Ashburn W,L,: Reproducibility of ejection fraction determinations by equilibrium radionuclide angiography in response to supine bicycle exercise, Journal of Nuclear Medicine 20: 491–495 (1979b)
Pfisterer, M,; Glaus L, and Burkart F,: Comparative effects of nitroglycerin, nifedipine and metoprolo! on regional left ventricular function in patients with one-vessel coronary disease, Circulation 67: 291–301 (1983)
Pfisterer, M,; Burkart, F, and Müller-Brand, J,: Important differences between acute and chronic hemodynamic effects of amiodarone in patients with chronic ischémic heart disease at rest and during ischemia-induced left ventricular dysfunction, Journal of the American College of Cardiology (in press, 1985)
Rutitzsky B,; Girotti A,L, and Rosenbaum M,B,: Efficacy of chronic amiodarone therapy in patients with variant angina pectoris and inhibition of ergonovine coronary constriction, American Heart Journal 103: 38–43 (1982)
Sicart, M,; Besse P,; Choussat A, and Bricaud H,: Action hémodynamique de l’amiodarone intraveineuse chez l’homme, Archives des Maladies du Coeur et des Vaisseaux 70: 219–226 (1977)
Vastesaeger M,; Gillot P, and Rasson G,: Etude clinique d’une nouvelle médication antiangineuse, Acta Cardiologica (Bruxelles) 22: 483–486 (1967)
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Amiodarone is marketed by Sanofi Labaz under the trademarks Cordarone (France), Cordarex (Germany), Cordarone-X (UK), Trangorex (Spain), Amiodar (Italy)
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Pfisterer, M., Burkart, F. Effect of Short and Long Term Administration of Amiodarone on Ischaemia-induced Left Ventricular Dysfunction. Molecular Diagnosis 29 (Suppl 3), 23–29 (1985). https://doi.org/10.2165/00003495-198500293-00004
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DOI: https://doi.org/10.2165/00003495-198500293-00004