Skip to main content
Log in

Limitation of Myocardial Infarct Size

Present Status

  • Leading Article
  • Published:
Drugs Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Aber, C.P.; Bass, N.M.; Berry, CL.; Carson, P.M.; Dobbs, R.J.; Fox, K.M.; Hamblin, J.J.; Haydu, S.P.; Howitt, G.; MacIver, J.E.; Portal, R.W.; Raftery, E.B.; Rousell, R.H. and Stock, J.P.P.: Streptokinase in acute myocardial infarction: A controlled multicentre study in the United Kingdom. British Medical Journal 2: 1100–1104 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Amery, A.; Reber, G.; Vermeulen, H.J. and Verstrate, M.: Single-blind randomised multicentre trial comparing heparin and streptokinase treatment in recent myocardial infarction. Acta Medica Scandinavica 505 (Suppl.): 5–35 (1969).

    Google Scholar 

  • Andersen, M.P.; Bechsgaard, P.; Frederiksen, J.; Hansen, D.A.; Jurgensen, H.J.; Nielsen, B.O.; Pedersen, F.; Pedersen-Bjergaard, O. and Rasmussen, S.L.: Effect of alprenolol on mortality among patients with definite or suspected acute myocardial infarction. Lancet 2: 865–868 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Armstrong, A.; Duncan, B.; Oliver, M.F.; Julian, D.G.; Donald, K.W.; Fulton, M.; Lutz, W. and Morrison, S.L.: Natural history of acute coronary heart attacks. A community study. British Heart Journal 34: 67–80 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Benda, Von L.; Haider, M. and Ambrosch, F.: Ergebnisse der osterreichischen Herzinfarktstudie mit Streptokinase. Weiner Klinische Wochenschrift 89: 779–783 (1977).

    Google Scholar 

  • Bett, J.H.N.; Biggs, J.C.; Chesterman, C.N.; Concannon, A.J.; Ibister, J.P.; Morgan, J.J.; O’Rourke, H.; McLean, K.H.; Saltups, A.; Hall, G.S.; Hirsh, J.; McDonald, LG.; O’Sullivan, E.F. Castaldi, P.A.; Rosenbaum, M.; de Gabriele, G. and Wallace, D.C.: Australian multicentre trial of streptokinase in acute myocardial infarction. Med. J. Aust. 1: 533 (1977).

    Google Scholar 

  • Bleifeld, W.H.; Hanrath, P. and Mathey, D.: Serial CPK determinations for evaluation of size and development of acute myocardial infarction. Circulation 53 (Suppl. 1): 108 (1976).

    Google Scholar 

  • Brochier, M.; Raynaud, R.; Planiol, T.; Fauchier, J.P.; Griguer, P.; Archambaud, D.; Pellois, A. and Clisson, M.: Le traitment par l’urokinase des infarctus du myocarde et syndromes de menace. Archives des Maladies du Coeur et des Vaisseaux 6: 563–569 (1975).

    Google Scholar 

  • Bussman, W.D.; Passek, D.; Seidel, W.; Klepzig, H. and Kalten-bach, M.: Reduktion der CK und CK-MB Enzymeaktivitat und der Infarktgrosse durch intravenoses nitroglycerin. Zeitschrift fur Kardiologie 69: 18–30 (1980).

    Google Scholar 

  • Cairns, J.A.; Holder, D.A.; Tanser, P. and Missirlis, E.: Intravenous hyaluronidase therapy for myocardial infarction in man: Double-blind trial to assess infarct size limitation. Circulation 65: 764–770 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Cairns, J.A.; Misserlis, E. and Fallen, E.L.: Myocardial infarction size from serial CPK: Variability of CPK serum entry ratio with site and model of infarction. Circulation 56 (Suppl. Ill): 70 (1977).

    Google Scholar 

  • Chapman, B.L.: Relation of cardiac complications to SGOT level in acute myocardial infarction]. British Heart Journal 34: 890–896 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Chiche, P.; Baligadoo, S.J. and Derrida, J.P.: A randomised trial of prolonged nitroglycerin infusion in acute myocardial infarction. Circulation 60: 11–165 (1979).

    Google Scholar 

  • Cohn, J.; Franciosa, J.A.; Francis, G.S.; Archibald, D.; Tristani, F.; Fletcher, R.; Montero, A.; Cintron, G.; Clarke, J.; Hager, D.; Saunders, R.; Cobb, F.; Smith, R.; Loeb, H. and Dettle, H.: Effect of short term infusion of sodium nitroprusside on mortality rate in acute myocardial infarction complicated by left ventricular failure. New England Journal of Medicine 306: 1129–1135 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Durrer, J.D.; Lie, K.I.; Van Capelle, F.J.L. and Durrer, D.: Effect of sodium nitroprusside on mortality in acute myocardial infarction. New England Journal of Medicine 306: 1121–1128 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Eshani, A.; Eiwy, G.A. and Sobel, B.E.: Effects of electrical counter,shock on creatine phosphokinase enzyme activity. American Journal of Cardiology 37: 12–18 (1976).

    Article  Google Scholar 

  • European Co-operative Study Group for Streptokinase Treatment in Acute Myocardial Infarction: Streptokinase in acute myocardial infarction. New England Journal of Medicine 301: 797–801 (1979).

    Article  Google Scholar 

  • European Working Party: Streptokinase in recent myocardial infarction. A controlled multicentre trial. British Medical Journal 3: 325–331 (1971).

    Article  Google Scholar 

  • Evemy, K.L. and Pentecost, B.L.: Intravenous and oral practolol in the acute stages of myocardial infarction. European Journal of Cardiology 7: 391–398 (1978).

    PubMed  CAS  Google Scholar 

  • Flint, E.J.; de Giovanni, J.; Cadigan, P.J.; Lamb, P. and Pentecost, B.L.: Effect of GL enzyme on mortality after myocardial infarction. Lancet 2: 871–874 (1982).

    Article  Google Scholar 

  • Gold, H.K.; Leinbach, R.C. and Maroko, P.R.: Propranolol induced reduction of signs of ischaemic injury during acute myocardial infarction. American Journal of Cardiology 38: 689–693 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Gormsen, J.: Biochemical elevation of standard treatment with streptokinase in acute myocardial infarction. Acta Medica Scandinavica 191: 77–85 (1972).

    PubMed  CAS  Google Scholar 

  • Grande, P.; Hansen, B.F.; Christiansen, C. and Naestoft, J.: Estimation of acute myocardial infarct size in man by serum CK-MB measurements. Circulation 66: 756–763 (1982).

    Article  Google Scholar 

  • Henderson, A.; Campbell, R.W.F. and Julian, D.G.: Effect of a highly purified hyaluronidase preparation on electrocardiographic changes in acute myocardial infarction. Lancet 2: 874–876 (1982).

    Article  Google Scholar 

  • Heng, M.K.; Noms, R.M.; Singh, B.N. and Barratt-Boyes, B.: Effects of glucose and glucose-insulin-potassium on haemodynamics and enzyme release after acute myocardial infarction. British Heart Journal 39: 748–757 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Heikinheimo, R.; Ahrenberg, P.; Honkapohja, H.; Iisalo, E.; Kallio, V.; Konttinen, Y.; Leskinen, O.; Mustaniemi, H.; Reinikainen, M. and Siitonen, L.: Fibrinolytic treatment in acute myocardial infarction. Acta Medica Scandinavica 189: 7–13 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Hockings, B.E.F.; Cope, G.D.; Clarke, G.M. and Taylor, R.R.: Randomised controlled trial of vasodilator therapy after myocardial infarction. American Journal of Cardiology 48: 345–352 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Holland, R.P. and Arnsdorf, M.R.: Solid angle theory and the electrocardiogram: Physiologic and quantitative interpretations. Progress in Cardiovascular Disease 19(6): 430–457 (1977).

    Article  Google Scholar 

  • Hjalmarson, A.; Elmfeldt, D.; Herlitz, J.; Holmberg, S.; Malek, I.; Nyberg, G.; Ryden, L.; Swedberg, K.; Vedin, A.; Waagstein, F.; Waidenstrom, A.; Waidenstrom, J.; Wedel, H.; Wilhelmsen, L. and Wilhelmsson, C.: Effect on mortality of metoprolol in acute myocardial infarction. Lancet 2: 823–827 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Jurgensen, H.J.; Frederiksen, J.; Hansen, D.A. and Pedersen-Bjergaard, O.: Limitation of myocardial infarct size in patients less than 60 years treated with alprenolol. British Heart Journal 45: 583–588 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Klein, W.; Pavek, P.; Brandt, D. et al.: Resultate einer Doppelblindstudie beim Myokard Infarkt; in Sailer (Ed.) Die Fibrinolyse-Behandlung des akuten Myokard-Infarktes, pp. 65–73 (Verlag Bruder Hollinek, Wein 1976).

    Google Scholar 

  • Leading article: Long term and short term beta-blockade after myocardial infarction. Lancet 1: 1159–1161 (1982).

    Google Scholar 

  • Lee, G.; Amsterdam, E.A.; Low, R.; Joye, J.A.; Kimchi, A.; De Maria, A.N. and Mason, D.T.: Efficacy of percutaneous transluminal coronary recanalisation utilising streptokinase thrombolysis in patients with acute myocardial infarction. American Heart Journal 102: 1159–1167 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Lippschutz, E.J.; Ambrus, J.L.; Ambrus, CM.; Constant, J.; Rekate, A.C.; Collins, G.L. and Sokal, J.E.: Controlled study of the treatment of coronary occlusion with urokinase-activated human plasmin. American Journal of Cardiology 16: 93–98 (1965).

    Article  Google Scholar 

  • Markis, J.E.; Malagold, M.; Parker, J.A.; Silverman, K.J.; Barry, W.H.; Als, A.V.; Paulin, S.; Grossman, W. and Braunwald, E.: Myocardial salvage after intracoronary thrombolysis with streptokinase in acute myocardial infarction. New England Journal of Medicine 305: 777–782 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Maroko, P.R.; Hillis, L.D.; Muller, J.C.; Tavazzi, L.; Heyndrickx, G.R.; Ray, M.; Chiariello, M.; Distante, A.; Askenazi, J.; Salerno, J.; Carpentier, J.; Reshnetnaya, N.I.; Radvany, P.; Libby, P.; Raabe, D.S.; Chazov, E.I.; Bobba, P. and Braunwald, E.: Favourable effects of hyaluronidase on electrocardiographic evidence of necrosis in patients with acute myocardial infarction. New England Journal of Medicine 296: 898–903 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Maroko, P.R.; Kjekhsus, J.K.; Sobel, B.E. et al.: Factors influencing infarct size following experimental coronary artery occlusion. Circulation 43: 67–82 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Mcllmoyle, L.; Evans, A.; Boyle, McC.D.; Cran, G.; Barber, J.M.; Elwood, H.; Salathia, K. and Shanks, R.: Early intervention in myocardial ischaemia. Proceedings of the British Cardiac Society 3–4 (Abstr.) (December, 1981).

  • Merx, W.; Dorr, R.; Rentrop, P.; Blanke, H.; Karsch, K.R.; Mathey, D.G.; Kremer, P.; Rutsch, W. and Schmutzler, H.: Evaluation of the effectiveness of intracoronary streptokinase infusion in acute myocardial infarction: Post-procedure management and hospital course in 204 patients. American Heart Journal 102: 1181–1187 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Mittra, B.: Potassium, glucose and insulin in treatment of myocardial infarction. Lancet 2: 607–609 (1965).

    Article  PubMed  CAS  Google Scholar 

  • MRC Working Party on the Treatment of Myocardial Infarction: Potassium, glucose and insulin treatment for acute myocardial infarction. Lancet 2: 1355–1360 (1968).

    Google Scholar 

  • Mueller, H.S. and Ayres, S.M.: Propranolol decreases sympathetic nervous activity as reflected by plasma catecholamines during evolution of myocardial infarction in man. Journal of Clinical Investigation 65: 338–346 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Muller, JE.; Maroko, P.R. and Braunwald, E.: Praecordial electrographic mapping. Circulation 57: 1 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Muller, J.E.; Stone, P.H.; Markis, J.E. and Braunwald, E.: Sounding board: Let’s not let the genie escape from the bottle —again. New England Journal of Medicine 304: 1294–1296 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Neuhaus, K.L.; Tebbe, U.; Sauer, G.; Kosternig, H. and Kreuzer, H.: Proceedings of the Deutsche Gesellschaft für Innere Medizin, Wiesbaden Meeting, April 1982.

  • Norris, R.M.; Barratt-Boyes, C.E.; Heng, M.K. and Singh, B.N.: Failure of ST-segment elevation to predict severity of acute myocardial infarction. British Heart Journal 38: 85–92 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Norris, R.M.; Clarke, E.D.; Sammel, N.L. and Smith, W.M.: Protective effect of propranolol in threatened myocardial infarction. Lancet 2: 907–909 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Norris, R.M.; Sammel, N.L.; Clarke, E.D. and Brandt, P.W.T.: Treatment of acute myocardial infarction with propranolol. Further studies on enzyme appearance and subsequent left ventricular function in treated and control patients with developing infarcts. British Heart Journal 43: 617–622 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Opie, L.H. and Owen, P.: Effect of glucose insulin potassium infusions on arteriovenous differences of glucose and of free fatty acids and on tissue metabolic changes in dogs with developing myocardial infarctions. American Journal of Cardiology 38: 310–321 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Page, D.L.; Caulfield, J.B.; Kastor, J.A.; DeSanctis, R.W. and Sanders, CA.: Myocardial changes associated with cardiogenic shock. New England Journal of Medicine 285: 133–137 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Palmeri, S.T.; Harrison, D.G.; Cobb, F.R.; Morris, K.G.; Harrell, F.E.; Ideker, R.E.; Selvester, R.H. and Wagner, G.S.: A QRS scoring system for assessing left ventricular function after myocardial infarction. New England Journal of Medicine 306: 4–9 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Pentecost, B.L.; Mayne, N.M.C. and Lamb, P.: Controlled trial of intravenous glucose potassium and insulin in acute myocardial infarction. Lancet 1: 946–948 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Peter, T.; Norris, R.M.; Clarke, E.D.; Heng, M.K.; Singh, B.N.; Williams, E.; Howell, D.R. and Ambler, P.K.: Reduction of enzyme levels by propranolol after acute myocardial infarction. Circulation 57: 1091–1095 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Ramsdale, D.R.; Faragher, E.B.; Bennett, D.H.; Bray, C; Ward, C.; Cruickshank, J.M.; Yusuf, S. and Sleight, P.: Pain relief in acute myocardial infarction by intravenous atenolol. American Heart Journal 103: 459–467 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Rapaport, E.: The fractional disappearance rate of the separate isoenzymes of creatine phosphokinase in the dog. Cardiovascular Research 9: 473–477 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Rentrop, P.; Blanke, H.; Karsch, K.R.; Rutsch, W.; Schartl, M.; Merx, W.; Dorr, R.; Mathey, D. and Kuck, K.: Changes in left ventricular function after intracoronary streptokinase infusion in clinically evolving myocardial infarction. American Heart Journal 102: 1188–1193 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Roe, C.R.; Cobb, F.R. and Starmer, CF.: The relationship between enzymatic and histologic estimates of the extent of myocardial infarction in conscious dogs with permanent coronary occlusion. Circulation 55: 438–449 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Rogers, W.J.; Segall, P.H.; McDaniel, H.G.; Mantle, J.A.; Russell, R.O. and Rackley, CE.: Prospective randomised trial of glucose insulin potassium in acute myocardial infarction: Effects on myocardial haemodynamics, substrates and rhythm. American Journal of Cardiology 43: 801–809 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Rossi, P.R.F.; Yusuf, S.; Ramsdale, D.; Furse, L.Y. and Sleight, P.: Reduction of ventricular arrhythmias by early intravenous atenolol in suspected acute myocardial infarction. British Medical Journal (In press, 1983).

  • Rutherford, J.D.; Singh, B.N.; Ambler, P.K. and Norris, R.M.: Plasma propranolol concentration in patients with angina and acute myocardial infarction. Clinical and Experimental Pharmacology and Physiology 3: 297–304 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Rude, R.E.; Muller, J.E. and Braunwald, E.: Efforts to limit the size of myocardial infarcts. Annals of Internal Medicine 95: 736–761 (1981).

    PubMed  CAS  Google Scholar 

  • Saltissi, S.; Robinson, P.S.; Coltart, DJ.; Webb-Peploe, M.M. and Croft, D.N.: Effects of early administration of a highly purified hyaluronidase preparation (GL enzyme) on myocardial infarct size. Lancet 2: 867–870 (1982).

    Article  Google Scholar 

  • Schroder, R.; Biamino, G. and von Leitner, E.R.: Intravenous short time thrombolysis in acute myocardial infarction. Circulation 64 (Suppl. IV): 10 (1981).

    Google Scholar 

  • Selwyn, A.P.; Ogunro, E. and Shillingford, J.P.: Natural history and evolution of ST segment changes and MB-CK release in acute myocardial infarction. British Heart Journal 39:. 994–998 (1977).

    Google Scholar 

  • Sloman, G. and Stannard, M.: Beta-adrenergic blockade and cardiac arrhythmias. British Medical Journal 4: 508–512 (1967).

    Article  Google Scholar 

  • Snow, P.J.D.: Treatment of acute myocardial infarction with propranolol. American Journal of Cardiology 18: 458–462 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Sobel, B.E.; Bresnahan, G.F.; Shell, W.E. and Yoder, R.D.: Estimation of infarct size in man and its relation to prognosis. Circulation 46: 640–648 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Sodi-Pallares, D.; Testelli, M.R.; Fishleder, B.L.; Bisteni, A.; Medrano, G.A.; Friedland, C and De Micheli, A.: Effect of an intravenous infusion of potassium-glucose-insulin on the electrocardiographic signs of myocardial infarction. A preliminary clinical report. American Journal of Cardiology 9: 166–181 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Thompson, P.L.; Fletcher, E. and Katavatis, V.: Enzymatic indices of myocardial necrosis: Influence on short and long term prognosis after myocardial infarction. Circulation 59: 113–119 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Thompson, P.L. and Katavatis, V.: Acute myocardial infarction: Evaluation of ST segment mapping. British Heart Journal 38: 1020–1024 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Tunstall-Pedoe, H.; Clayton, D.; Morris, J.N.; Brigden, W. and McDonald, L.: Coronary heart attacks in East London. Lancet 2: 833–838 (1975).

    Article  Google Scholar 

  • Waagstein, F. and Hjalmarson, A.C.: Double blind study of the effect of cardioselective beta-blockade on chest pain in acute myocardial infarction. Acta Medica Scandinavica Suppl. 587: 201–208 (1975).

    Google Scholar 

  • Yusuf, S.; Lopez, R.; Maddison, A.; Maw, P.; Ray, N.; McMillan, S. and Sleight, P.: Value of ECG in predicting and estimating infarct size in man. British Heart Journal 42: 286–293 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Yusuf, S.; Lopez, R.; Maddison, A. and Sleight, P.: Electrocar-dographic and enzyme evolution of infarct size in man. Circulation 57, 58 (Suppl. II): 172 (1978).

    Google Scholar 

  • Yusuf, S.; Lopez, R.; Maddison, A. and Sleight, P.: Variability of ECG and enzyme evolution of myocardial infarction in man. British Heart Journal 45: 271–280 (1980a).

    Article  Google Scholar 

  • Yusuf, S.; Ramsdale, D.; Peto, R.; Bennett, D.; Furse, L.; Bray, C. and Sleight, P.: Early intravenous atenolol treatment in suspected acute myocardial infarction: Preliminary report of a randomised trial. Lancet 2: 273–276 (1980b).

    Article  PubMed  CAS  Google Scholar 

  • Yusuf, S.; Sleight, P.; Rossi, P.R.F.; Ramsdale, D.; Peto, R.; Furse, L.; Motwani, R.; Parish, S.; Gray, R.; Bennett, D. and Bray, C.: Reduction in infarct size, arrhythmias, chest pain and morbidity by early intravenous beta-blockade in suspected acute myocardial infarction. Drugs 25 (Suppl. 2): 303–307 (1983).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yusuf, S., Sleight, P. Limitation of Myocardial Infarct Size. Drugs 25, 441–450 (1983). https://doi.org/10.2165/00003495-198325050-00001

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-198325050-00001

Keywords

Navigation