Summary
30 patients (21 male, 9 female; mean age 60.6 ± 10 years) hospitalised for unstable angina underwent clinical and isotopic evaluation (radionuclide angiography) before and 1 week after treatment with atenolol (100 mg/day). 23 patients were re- evaluated 1 month later and 15 underwent coronary arteriography and contrast ventriculography.
Atenolol proved to be clinically efficient (i.e. total disappearance of chest pain) in 43% (group 1) and partially efficient (atenolol combined with another antianginal drug) in 27% (group 2). The mid- term assessment confirms these results. There was no significant change in left ventricular global ejection fraction (GEF) before (62 ± 12) and during treatment (59 ± 14). The GEF slightly decreased in only 23% of the patients (65 ± 10) before and (54 ± 10) after treatment. In 77% there was no change of left ventricular wall motion.
Once daily atenolol therapy had a good β- blocking effect and proved to be efficient in the treatment of unstable angina without left ventricular failure in two- thirds of the patients during hospitalisation and mid- term follow up.
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Godenir, J.P., Amor, M., Cherrier, F. et al. Atenolol in Unstable Angina. Drugs 25 (Suppl 2), 172–176 (1983). https://doi.org/10.2165/00003495-198300252-00051
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DOI: https://doi.org/10.2165/00003495-198300252-00051