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Activation of Prejunctional β-Adrenoceptors by Adrenaline Acting as a Co-transmitter

A Possible Cause of Hypertension

  • Section 1B: Hypertension
  • Published:
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Summary

Adrenaline released into the circulation can be accumulated in sympathetic nerve endings. Release of adrenaline from the nerves enhances noradrenaline release, as adrenaline activates a local modulatory system mediated by presynaptic β-adrenoceptors. It is postulated that stress-induced adrenaline release from the adrenal gland could, through this mechanism, lead to hypertension.

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Authors and Affiliations

  1. Department of Pharmacology, University of Melbourne, Melbourne, Victoria, 3052, Australia

    M. J. Rand, H. Majewski & L.-H. Tung

  2. Pharmakologisches Institut der Universität, Freiburg, Australia

    M. J. Rand, H. Majewski & L.-H. Tung

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  1. M. J. Rand
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  2. H. Majewski
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  3. L.-H. Tung
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Rand, M.J., Majewski, H. & Tung, LH. Activation of Prejunctional β-Adrenoceptors by Adrenaline Acting as a Co-transmitter. Drugs 25 (Suppl 2), 64–68 (1983). https://doi.org/10.2165/00003495-198300252-00012

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  • DOI: https://doi.org/10.2165/00003495-198300252-00012

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