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Use of Monoclonal Antibodies and Liposomes to Improve Drug Delivery

Present Status and Future Implications

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References

  • Allen, T.: A study of phospholipid interactions between high density lipoprotein and small unilamellar vesicles. Biochimica Biophysica Acta 640: 385–397 (1981).

    Article  CAS  Google Scholar 

  • Barbet, J.; Machy, P. and Leserman, L.D.: Monoclonal antibody covalently coupled to liposomes: specific targeting to cells. Journal of Supramolecular Structure 16: 243–258 (1981).

    Article  CAS  Google Scholar 

  • Bartal, A.H.; Feit, C.; Erlandson, R. and Hirshaut, V.: The presence of viral particles in hybridoma clones secreting monoclonal antibodies. New England Journal of Medicine 306: 1423 (1982).

    PubMed  CAS  Google Scholar 

  • Blytham, H.E.; Casellas, P.; Gross, O.; Gross, P.; Jansen, F.K.; Paolucci, F.; Pan, B. and Vidal, H.: Immunotoxins: hybrid molecules of monoclonal antibodies and a toxin subunit specifically kill tumour cells. Nature 290: 145–146 (1981).

    Article  Google Scholar 

  • Damen, J.; Regts, J. and Scherphof, G.: Transfer and exchange of phospholipid between small unilamellar liposomes and rat plasma high density lipoproteins. Biochimica et Biophysica Acta 665: 538–545 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Edwards, P.A.W.: Some properties and applications of monoclonal antibodies. Biochemical Journal 200: 1–10 (1981).

    PubMed  CAS  Google Scholar 

  • Ellens, H.; Morselt, H. and Scherphof, G.: In vivo fate of large unilamellar sphingomyelin-cholesterol liposomes after intraperitoneal and intravenous injection into rats. Biochimica Biophysica Acta 674: 10–18 (1981).

    Article  CAS  Google Scholar 

  • Froese, G.; Berczi, I. and Israels, L.G.: Tumour-cell antibody interactions. Immunology 45: 313–323 (1982).

    PubMed  CAS  Google Scholar 

  • Ghosh, P.; Das, P.K. and Bachhawat, B.K.: Targeting of liposomes towards different cell types of rat liver through the involvement of liposomal surface glycosides. Archives of Biochemistry and Biophysics 213: 266–270 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Gilliland, D.G.; Stephlewski, Z.; Collier, R.J.; Mitchell, K.F.; Chang, T.H. and Koprowski, H.: Antibody-directed cytotoxic agents. Use of monoclonal antibody to direct action of toxin A chains; to colerectal carcinoma cells. Proceedings of the National Academy of Sciences, USA 77: 4539–4543 (1980).

    Google Scholar 

  • Gregoriadis, G.: Catabolism of glycoproteins; in Dingle and Dean (Eds) Lysosomes in Biology and Pathology, pp.265–294 (North Holland, Amsterdam, Oxford 1975).

    Google Scholar 

  • Gregoriadis, G.: The carrier potential of liposomes in biology and medicine. New England Journal of Medicine 295: 704–710; 765-770 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Gregoriadis, G.: Tailoring liposome structure. Nature 283: 814–815 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Gregoriadis, G.: Targeting of drugs: Implications in medicine. Lancet 2: 241–247 (1981a).

    Article  PubMed  CAS  Google Scholar 

  • Gregoriadis, G.: Liposomes: a role in vaccines? Clinical Immunology Newsletter 2: 33–36 (1981b).

    Article  Google Scholar 

  • Gregoriadis, G. and Meehan, A.: Interaction of antibody-bearing small unilamellar liposomes with antigen coated cells: the effect of antibody and antigen concentration on the liposomal and cell surface respectively. Biochemical Journal 200: 211–216 (1981).

    PubMed  CAS  Google Scholar 

  • Gregoriadis, G. and Senior, J.: The phospholipid component of small unilamellar liposomes controls the rate of clearance of entrapped solutes from the circulation. FEBS Letters 119: 43–46 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Gregoriadis, G.; Senior, J. and Trouet, A. (Eds): Targeting of Drugs (Plenum Press, London, New York 1982).

    Google Scholar 

  • Hart, I.R.; Fogler, W.E.; Poste, G. and Fidler, I.: Toxicity studies of liposome-encapsulated immunomodulators administered intravenously to dogs and mice. Cancer Immunology and Immunotherapy 10: 157–166 (1981).

    CAS  Google Scholar 

  • Huang, A.; Huang, L. and Kennel, S.J.: Monoclonal antibody covalently coupled with fatty acid. Journal of Biological Chemistry 255: 8015–8018 (1980).

    PubMed  CAS  Google Scholar 

  • Kaye, S.B.: Liposomes — problems and promise as selective drug carriers. Cancer Treatment Reviews 8: 27–50 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Khato, J.; Priester, E.R. and Sieber, S.M.: Enhanced lymph node uptake of melphalan following liposomal entrapment and effects on lymph node metastasis in rats. Cancer Treatment Reports 66: 517–527 (1982).

    PubMed  CAS  Google Scholar 

  • Kirby, C. and Gregoriadis, G.: Plasma-induced release of solutes from small unilamellar liposomes is associated with pore formation in the bilayers. Biochemical Journal 199: 251–254 (1981).

    PubMed  CAS  Google Scholar 

  • Kirby, C.; Clarke, J. and Gregoriadis, G.: Cholesterol content of small unilamellar liposomes controls phospholipid loss to high density lipoproteins in the presence of serum. FEBS Letters III: 324–328 (1980a).

    Article  Google Scholar 

  • Kirby, C.; Clarke, J. and Gregoriadis, G.: Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro. Biochemical Journal 186: 591–598 (1980b).

    PubMed  CAS  Google Scholar 

  • Krolick, K.A.; Uhr, J.W. and Vitetta, E.S.: Selective killing of leukaemia cells by antibody-toxin conjugates: implications for autologous bone marrow transplantation. Nature 295: 604–605 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Levine, G.; Ballou, B.; Reiland, J.; Solter, D.; Gumerman, L. and Hakala, T.: Localization of 131I-labelled tumour-specific monoclonal antibody in the tumour-bearing BALB/c mouse. Journal of Nuclear Medicine 21: 570–573 (1980).

    PubMed  CAS  Google Scholar 

  • Mach, J-P.; Buchegger, F.; Forni, M.; Ritzchard, J.; Berche, C.; Lumboso, J-D; Schreyer, M.; Giradet, C.; Accolla, R.S. and Carrel, S.: Use of radiolabelled monoclonal anti-CES antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy. Immunology Today 2: 239–249 (1981).

    Article  Google Scholar 

  • Martin, F.J.; Hubbell, W.L. and Papahadjopoulos, D.: Immunospecific targeting of liposomes to cells: A novel and efficient method for covalent attachment of Fab’ fragments via disulfide bonds. Biochemistry 20: 4229–4238 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Marx, J.L.: Monoclonal antibodies in cancer. Science 216: 283–285 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Mauk, M.R.; Gamble, R.C. and Baldeschwieler, J.D.: Targeting of lipid vesicles: specificity of carbohydrate receptor analogues for leucocytes in mice. Proceedings of the National Academy of Science, USA 77: 4430–4434 (1980).

    Article  CAS  Google Scholar 

  • McCullough, H.N. and Juliano, R.L.: Organ-selective action of an antitumour drug: Pharmacologic studies of liposome-encapsulated cytosine arabinoside administered via the respiratory system of the rat. Journal of National Cancer Institute 63: 727–731 (1979).

    CAS  Google Scholar 

  • Milstein, G: Monoclonal antibodies. Scientific American 243(4): 56–64 (1980).

    Article  Google Scholar 

  • Moshakis, V.; McIlhinney, R.A.J. and Neville, A.M.: Cellular distribution of monoclonal antibody in human tumours after i.v. administration. British Journal of Cancer 44: 663–669 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Olsnes, S.: Directing toxins to cancer cells. Nature 190: 84 (1981).

    Article  Google Scholar 

  • O’Neill, G.J.: The use of antibodies as drug carriers; in Gregoriadis (Ed.) Drug Carriers in Biology and Medicine pp.23–41 (Academic Press, London, New York 1979).

    Google Scholar 

  • Rahman, Y-E.: Liposomes and chelating agents; in Gregoriadis and Allison (Eds) Liposomes in Biological Systems pp.265–298 (John Wiley and Sons, Chichester, New York 1980).

    Google Scholar 

  • Ryman, B.E. and Tyrrell, D.A.: Liposomes — bags of potential. Essays in Biochemistry 16: 49–98 (1980).

    PubMed  CAS  Google Scholar 

  • Scheinberg, D.A. and Strand, M.: Tumour imaging with radioactive metal chelates conjugated to monoclonal antibodies. Science 215: 1511–1513 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Sikora, K.; Alderson, T.; Phillips, J. and Watson, J.V.: Human hybridomas from malignant gliomas. Lancet 1: 11–14 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Tom, B.H. and Six, H.R. (Eds): Liposomes and Immunobiology (Elsevier/North Holland, New York, Amsterdam 1980).

    Google Scholar 

  • Yatvin, M.B.; Mühlensiepen, H.; Proschen, W.; Weinstein, J.N. and Feinendegen, L.E.: Selective delivery of liposome-associated cisdichlorodiammineplatinum (II) by heat and its influence on tumour drug uptake and growth. Cancer Research 41: 1602–1607 (1981).

    PubMed  CAS  Google Scholar 

  • Youle, R.J. and Neville, D.M. Jr: Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell type specific toxin. Proceedings of the National Academy of Sciences, USA 77: 5483–5486 (1980).

    Article  CAS  Google Scholar 

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  1. Clinical Research Centre, Watford Road, Harrow, Middlesex, HA1 3UJ, England

    Gregory Gregoriadis

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Gregoriadis, G. Use of Monoclonal Antibodies and Liposomes to Improve Drug Delivery. Drugs 24, 261–266 (1982). https://doi.org/10.2165/00003495-198224040-00001

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