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Nasal Decongestants

Summary

When a patient presents with nasal obstruction a correct diagnosis must be made. Treatment may not always be required, and the need for intervention should be balanced against the risks of therapy. If the patient has an acute problem, such as the common cold or sinusitis, a topical decongestant may be the most immediately effective remedy, but this should never be continued for more than a few days and the patient should be warned against buying similar proprietary products. In more chronic cases, such as allergic or vasomotor rhinitis, or when decongestion of mucosa away from the nose (Eustachian tube) is required, oral treatment is best. A sympathomimetic administered orally (pseudoephedrine or phenylephrine) may be sufficient, or an antihistamine alone may be helpful in allergic rhinitis. Combination products are frequently effective, possibly more so than the individual ingredients, but when using such products the prescriber must remember the contraindications and precautions for each ingredient.

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References

  • Britton, M.G.; Empey, D.W.; John, G.C.; McDonnell, K.A. and Hughes, D.T.D.: Histamine challenge and anterior nasal rhinometry: Their use in the assessment of pseudoephedrine and triprolidine as nasal decongestants in subjects with hay fever. British Journal of Clinical Pharmacology 6: 51–58 (1978).

    PubMed  Article  CAS  Google Scholar 

  • Bye, C.E.; Cooper, J.; Empey, D.W.; Fowle, A.S.E.; Hughes, D.T.D.; Letley, E. and O’Grady, J.: Effects of pseudoephedrine and triprolidine alone and in combination on symptoms of the common cold. British Medical Journal 11: 189–190(1980).

    Article  Google Scholar 

  • Capel, L.H. and McKelvie, P.: Disodium cromoglycate in hayfever. Lancet 1: 575–576 (1971).

    PubMed  Article  CAS  Google Scholar 

  • Empey, D.W.; Bye, C.E.; Hodder, M. and Hughes, D.T.D.: A double-blind crossover trial of pseudoephedrine and triprolidine, alone and in combination, for the treatment of allergic rhinitis. Annals of Allergy 34(1): 41–46 (1975).

    PubMed  CAS  Google Scholar 

  • Empey, D.W.; Young, G.A.; Letley, E.; John, G.C.; Smith, P.; McDonnell, K.A.; Bagg, L.R. and Hughes, D.T.D.: Dose-response study of the nasal decongestant and cardiovascular effects of pseudoephedrine. British Journal of Clinical Pharmacology 9: 351–358 (1980).

    PubMed  Article  CAS  Google Scholar 

  • Feinberg, A.R. and Feinberg, S.M.: The ‘nose drop nose’ due to oxymeta oline CAfrin’) and other topical vasoconstrictors. Illinois Medical Journal 140: 50 (1971).

    PubMed  CAS  Google Scholar 

  • Girard, J.P. and Bertrand, J.: Study of 2 % solution of sodium cromoglycate in perennial rhinitis assessed by subjective and objective parameters. Clinical Allergy 5/3: 301 (1975).

    Google Scholar 

  • Medical Research Council Special Committee: Clinical trials of anti-histaminic drugs in the prevention and treatment of the common cold. British Medical Journal 2: 425–429 (1950).

    Article  Google Scholar 

  • Mygind, N.: Local effect of intranasal beclomethasone dipropionate aerosol in hay fever. British Medical Journal 2: 464–466 (1973).

    Article  Google Scholar 

  • Pakes, G.E.; Brogden, R.N.; Heel, R.C.; Speight, T.M. and Avery, G.S.: Flunisolide: A review of its pharmacological properties and therapuetic efficacy in rhinitis. Drugs 19: 397–411 (1980).

    PubMed  Article  CAS  Google Scholar 

  • Pearlman, D.S.: Antihistamines: Pharmacology and Clinical use. Drugs 12: 258–273 (1976).

    PubMed  Article  CAS  Google Scholar 

  • Proctor, D.F. and Adams, G.K.: Physiology and pharmacology of nasal function and mucus secretion. Pharmacology and Therapeutics 2(3): 493–509 (1976).

    CAS  Google Scholar 

  • West, S.; Brandon, B.; Stolley, P. and Rumrill, R.: A review of antihistamines and the common cold. Pediatrics 56: 100 (1975).

    PubMed  CAS  Google Scholar 

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Empey, D.W., Medder, K.T. Nasal Decongestants. Drugs 21, 438–443 (1981). https://doi.org/10.2165/00003495-198121060-00003

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  • DOI: https://doi.org/10.2165/00003495-198121060-00003

Keywords

  • Rhinitis
  • Allergic Rhinitis
  • Ephedrine
  • Nasal Obstruction
  • Common Cold