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Single Drug or Combination Therapy for Epilepsy?

  • Practical Therapeutics
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References

  • Coatsworth, J.J.: Studies on the Clinical Efficacy of Marketed Antiepileptic Drugs; NINDS Monograph No. 12 (US Government Printing Office, Washington DC 1971).

  • Dellaportas, C.I.; Marshall, W.; Galbraith, A.W.; Shorvon, S.D. and Reynolds, E.H.: The evolution of chronic toxicity in previously untreated patients on phenytoin or carbamazepine. Communication to the 11th Epilepsy International Symposium, Florence 1979 (In press, 1981).

  • Eadie, M.J. and Tyrer, J.H.: Anticonvulsant Therapy. Pharmacological Basis and Practice (Churchill Livingstone, Edinburgh 1980).

  • Gastaut, H. and Osuntokun, B.O.: Proposals on antiepileptic pharmacotherapy for use in developing countries. Epilepsia 17: 355–360 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Guelen, P.J.M.; van der Kleijn, E. and Woudstra, U.: Statistical analysis of pharmacokinetic parameters in epileptic patients chronically treated with antiepileptic drugs; in Schneider et al. (Eds) Clinical Pharmacology of Antiepileptic Drugs, pp.2–10 (Springer-Verlag, Berlin 1975).

    Chapter  Google Scholar 

  • Milano Collaborative Group for Studies on Epilepsy: Long-term intensive monitoring in the difficult patient. Preliminary results of 16 months of observations — usefulness and limitations; in Gardner-Thorpe et al. (Eds) Antiepileptic Drug Monitoring, pp. 197–213 (Pitman, Tunbridge Wells 1977).

  • Reynolds, E.H.: Serum levels of anticonvulsant drugs. Interpretation and clinical value. Pharmacology and Therapeutics 8: 217–235 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Reynolds, E.H. and Shorvon, S.D.: Monotherapy or polytherapy for epilepsy? Epilepsia 22: 1–10 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Rodin, E.A.: The Prognosis of Patients with Epilepsy (Thomas, Springfield, 1968).

    Google Scholar 

  • Schmidt, D.: One drug treatment with phenytoin in difficult-to-treat epilepsies with complex partial seizures: a preliminary report of a prospective study; in Johannessen et al. (Eds) Antiepileptic Therapy: Advances in Drug Monitoring, pp.221–228 (Raven Press, New York 1979).

    Google Scholar 

  • Shorvon, S.D. and Reynolds, E.H.: Unnecessary polypharmacy for epilepsy. British Medical Journal 1: 1635–1637 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Shorvon, S.D.; Chadwick, D.; Galbraith, A.W. and Reynolds, E.H.: One drug for epilepsy. British Medical Journal 1: 474–476 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Shorvon S.D. and Reynolds, E.H.: Reduction of polypharmacy for epilepsy. British Medical Journal 2: 1023–1025 (1979).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. King’s College Hospital, University Department of Neurology, Denmark Hill, London, SE5, England

    E. H. Reynolds & S. D. Shorvon

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  1. E. H. Reynolds
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  2. S. D. Shorvon
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Reynolds, E.H., Shorvon, S.D. Single Drug or Combination Therapy for Epilepsy?. Drugs 21, 374–382 (1981). https://doi.org/10.2165/00003495-198121050-00005

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