References
Bandisode, M.S. and Boscheil, B.R.: Double-blind clinical evaluation of mazindol (42-548) in obese diabetics. Current Therapeutic Research 18: 816 (1975).
Beckett, A.H.: A comparative study of the pharmacokinetics of fenfluramine, ethylamphetamine, diethylpropion and their metabolites. Current Medical Research and Opinion 6 (Suppl. 1): 107–117 (1979).
Beckett, A.H. and Brookes, L.G.: The metabolism and urinary excretion in man of phentermine, and the influence of N-methyl and p-chloro-substitution. Journal of Pharmacy and Pharmacology 23: 288–294 (1971).
Blundell, J.E.; Latham, C.J.; Moniz, E.; McArthur, R.A. and Rogers, P.J.: Structural analysis of the actions of amphetamine and fenfluramine on food intake and feeding behaviour in animals and in man. Current Medical Research and Opinion 6 (Suppl. 1): 34–54 (1979).
Campbell, D.B.: Plasma concentration in fenfluramine and its metabolite, norfenfluramine, following single and repeated oral administration. British Journal of Pharmacology 43: 465 (1971).
Carabillo, E.A.: USA drug abuse warning network; in Garattini and Samanin (Eds) Central Mechanism of Anorectic Drugs, pp.461–471 (Raven Press, New York 1978).
Clarke, B.F. and Campbell, I.W.: Comparison of metformin and chlorpropamide in non-obese maturity-onset diabetics controlled by diet. British Medical Journal 2: 1576 (1977).
Clarke, B.F. and Duncan, L.J.P.: Comparison of chlorpropamide and metformin treatment on weight and blood glucose response of uncontrolled obese diabetics. Lancet 1: 123 (1968).
Connell, P.H.: Central nervous system stimulation; in Dukes (Ed) Meyler’s Side Effects of Drugs, Vol. 8, p.l (Excerpta Medica, Amsterdam and Oxford 1975).
Craddock, D.: The free diet — 150 cases. International Journal of Obesity 1: 127–134 (1977).
Danforth, E.; Burger, A.G.; Goldman, R.F. and Sims, E.A.H.: Thermogenesis during weight gain; in Bray (Ed) Recent Advances in Obesity Research II, p.229 (Newman Publishing Ltd, London 1978).
Doar, J.W.H.; Thomson, M.E.; Wilde, C.E. and Sewell, P.F.J.: The influence of fenfluramine on oral glucose tolerance tests, plasma sugar and insulin levels in newly-diagnosed late-onset diabetic patients. Current Medical Research and Opinion 6 (Suppl. 1): 247–254 (1979).
Douglas, J.G.; Ford, M.J. and Munro, J.F.: Patient motivation and predicting outcome in a hospital obesity clinic. International Journal of Obesity. (In press, 1981).
Duncan, L.J.P.; Rose, K. and Meiklejohn, A.P.: Phenmetrazine hydrochloride and methylcellulose in the treatment of refractory obesity. Lancet 1: 1262 (1960).
Editorial: Diethylpropion psychosis. Medical Journal of Australia 2: 1052 (1970).
Enzi, G.; Baritussio, A.; Machion, E. and Crepaldi, G.: Short-term and long-term clinical evaluation of a non-amphetamine anorexiant (mazindol) in the treatment of obesity. Journal of International Medical Research 4: 305–318 (1976).
Garattini, S.; Borroni, E.; Mennini, T. and Samanin, R.: Differences and similarities among anorectic agents; in Garattini and Samanin (Eds) Central Mechanism of Anorectic Drugs, pp.127–143 (Raven Press, New York 1978).
Garrow, J.S.: Weight penalties. British Medical Journal 2: 1171–1172 (1979).
Hinsvark, O.N.; Truant, A.P.; Jenden, D.J. and Steinburn, J.A.: The oral bioavailability and pharmacokinetics of soluble and resin-bound forms of amphetamine and phentermine in man. Journal of Pharmacokinetics and Biopharmaceutics 1: 319 (1973).
Hudson, K.D.: The anorectic and hypotensive effect of fenfluramine in obesity. Journal of the Royal College of General Practitioners 27: 497–501 (1977).
Innes, J.A.; Watson, M.L.; Ford, M.J.; Munro, J.F.; Stoddart, M.E. and Campbell, D.B.: Plasma fenfluramine levels, weight loss and side effects. British Medical Journal 2: 1322–1325 (1977).
Jung, R.T.; Shetty, P.S.; James, W.P.T.; Barrand, M.A. and Callingham, B.: Reduced thermogenesis in obesity. Nature 279: 322–323 (1979).
Keen, H.: Antidiabetic agents and vascular events. Journal of Clinical Pathology 28 (Suppl.): 99 (1975).
Knatterud, G.L., Meinert, C.L.; Klimt, C.R., Osborne, R.K. and Martin, D.B.: The UGDP: A study of the effects of hypoglycaemic agents on vascular complications in patients with adultonset diabetes. Evaluation of phenformin therapy. Diabetes 24 (Suppl. 1): 65 (1975).
Lasagna, L.: Attitude towards appetite suppressants. Journal of the American Medical Association 225: 44 (1973).
Lawson, A.A.H.; Strong, J.A.; Roscoe, P. and Gibson, A.: Comparison of fenfluramine and metformin in the treatment of obesity. Lancet 1: 437–441 (1970).
Lüllmann-Rauch, R. and Reil, G.H.: Chlorphentermine-induced lipidosis-like ultrastructural changes in lungs and adrenal glands of several species. Toxicology and Applied Pharmacology 30: 408–421 (1974).
Maclay, W.P. and Wallace, M.G.: A multicenter general practice trial of mazindol in the treatment of obesity. Practitioner 218: 431 (1977).
Matthews, P.A.: Diethylpropion in the treatment of obese patients seen in general practice. Current Therapeutic Research 17: 340–346 (1975).
Miller, D.S. and Parsonage, S.: Resistance to slimming. Adaption or illusion? Lancet 1: 773 (1975).
Morselli, P.L.; Maggini, C.; Placidi, G.F.; Gemeni, R. and Tegneni, G.: An integrated approach to the clinical pharmacology of anorectic drugs; in Garattini and Samanin (Eds) Central Mechanism of Anorectic Drugs, pp.243–265 (Raven Press, New York 1978).
Munro, J.F.; MacCuish, A.C.; Wilson, E.M. and Duncan, L.J.P.: Comparison of continuous and intermittent anorectic therapy in obesity. British Medical Journal 1: 352 (1968).
Munro, J.F.; Seaton, D.A. and Duncan, L.J.P.: Treatment of refractory obesity with fenfluramine. British Medical Journal 2: 624–625 (1966).
Paeprer, K.: Hypotonie und appetitzugler. Arztol Praxis 22: 1397 (1970).
Preston, P.G.; Ford, M.J.; Munro, J.F. and Campbell, D.B.: The variable response to fenfluramine in obesity. International Journal of Obesity 3: 359–361 (1979).
Rothwell, N.J. and Stock, M.J.: A role for brown adipose tissue in diet-induced thermogenesis. Nature 281: 31 (1979).
Rubin, R.T.: Acute psychotic reaction following ingestion of phentermine. American Journal of Psychiatry 120: 1124 (1964).
Rudinger, E. (Ed.): Consumers’ Association: Which way to slim? (Eyre and Spottiswoode, Portsmouth 1978).
Sandoz Pharmaceuticals: Sanorex. A monograph (Sandoz Inc, New Jersey 1973).
Scoville, B.A.: Review of amphetamine-like drugs by the Food & Drug Administration: Clinical data and value judgements; in Bray (Ed) Obesity in Perspective. Proceedings of the Fogarty Conference, p.441 (US Government, Washington 1973).
Seaton, D.A.; Duncan, L.J.P.; Rose, K. and Scott, A.M.: Diethylpropion in the treatment of refractory obesity. British Medical Journal 1: 1009–1011 (1961).
Seaton, D.A.; Rose, J. and Duncan, L.J.P.: Sustained-action chlorphentermine in the correction of refractory obesity. Practitioner 193: 698–702 (1964a).
Seaton, D.A.; Rose, J. and Duncan, L.J.P.: A comparison of the appetite suppressing properties of dexamphetamine and phentermine. Scottish Medical Journal 9: 482–485 (1964b).
Smith, R.C.F.: The long term control of obesity using sustained release appetite suppression. British Journal of Clinical Practice 16: 6–9 (1962).
Smith, R.G.; Innes, J.A. and Munro, J.F.: Double-blind evaluation of mazindol in refractory obesity. British Medical Journal 3: 284 (1975).
Steel, J.M. and Briggs, W.: Withdrawal depression in obese patients after fenfluramine treatment. British Medical Journal 3: 26–27 (1972).
Stunkard, A.J.; Craighead, L.W. and O’Brien, R.: Controlled trial of behaviour therapy, pharmacotherapy and their combination in the treatment of obesity. Lancet 2: 1045–1047 (1980).
Turner, P. and Kirby, M.J.: Some evidence for a peripheral mechanism of action of anorectic drugs; in Garattini and Samanin (Eds) Central Mechanism of Anorectic Drugs, pp.295–299 (Raven Press, New York 1978).
Waal-Manning, H.J. and Simpson, F.O.: Fenfluramine in obese patients on various antihypertensive drugs. Double-blind controlled trial. Lancet 2: 1392 (1969).
Wales, J.K.: The effects of fenfluramine on obese, maturity-onset diabetic patients. Current Medical Research and Opinion 6 (Suppl. 1): 226 (1979).
Wallace, A.G.: AN 448 Sandoz (mazindol) in the treatment of obesity. Medical Journal of Australia 1: 343 (1976).
Wright, G.J.; Lang, J.F.; Lemieux, R.E. and Goodfriend, M.J.: The objective and timing of drug disposition studies. Appendix III. Diethylpropion and its metabolites in the blood plasma of the human after subcutaneous and oral administration. Drug Metabolism Reviews 4: 267 (1975).
References
Bray, G.A.: Obesity in perspective. Proceedings of the Fogarty Conference (US Government, Washington 1973).
Craddock, D.: in Obesity and its Management (Churchill Livingstone, London and New York 1973).
Garattini, S. and Samanin, R.: in Central Mechanisms of Anorectic Drugs (Raven Press, New York 1978).
Garrow, J.S.: in Energy Balance and Obesity in Man, 2nd edition (North Holland Publishing Co, Amsterdam 1978).
Munro, J.F.: Clinical aspects of the treatment of obesity by drugs: A review. International Journal of Obesity 3: 171–180(1979).
Munro, J.F.: in Treatment of Obesity (MTP Press, Lancaster 1979).
Sullivan, A.C. and Cornai, K.: Pharmacological treatment of obesity. International Journal of Obesity 2: 167–190 (1978).
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Douglas, J.G., Munro, J.F. The Role of Drugs in the Treatment of Obesity. Drugs 21, 362–373 (1981). https://doi.org/10.2165/00003495-198121050-00004
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DOI: https://doi.org/10.2165/00003495-198121050-00004