Summary
A comparative trial was carried out in 4 orphanages in Seoul, to compare the anthelminthic efficacy of oxantel-pyrantel suspension and mebendazole tablets against mixed infections of Ascaris lumbricoides and Trichuris trichiura.
40 patients were divided into 4 groups and received oxantel-pyrantel suspension at 15 or 20mg/kg once only or on 2 consecutive days. Another group of 20 patients was treated with 100mg of mebendazole twice a day for 3 days.
Both drugs achieved a 100% cure rate for Ascaris infections. Against Trichuris infections, the average cure rate and egg reduction rate of oxantel-pyrantel treated groups was 87.5 % and 92.3 % respectively, and that for mebendazole was 65 % and 89.1%.
There were no side-effects. The results of the present study suggest that oxantel-pyrantel is more effective in the treatment of mixed infections of Ascaris and Trichuris, and was more acceptable to the patients, than mebendazole.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cho, S.Y.: Anthelmintic efficacy of combined preparation of pyrantel pamoate and oxantel pamoate on human intestinal nematodes. Korean Journal of Pharmacology 12: 69–73 (1976).
Kim, C.H.: Anthelmintic effectiveness of mebendazole on Ascarisand Trichuris infection. Korean Journal of Parasitology 12(2): 172 (1974).
Lee, S.H.; Seo, B.S.; Cho, S.Y. and Kang, S.Y.: Clinical trial of oxantel pamoate (CP-14 445) on Trichocephalus trichiurus infection. Korean Journal of Parasitology 14: 25–31 (1976).
Lim, J.K.: Anthelmintic effect of oxantel pamoate against Trichocephalus trichurus infection. Korean Journal of Pharmacology 10: 97–101 (1974).
Ministry of Health: Prevalence of intestinal parasites in Korea (monograph). Ministry of Health, Republic of Korea, Seoul (1974).
Park, C.W.; Lim, J.K.; Shim, S.J.; Kim, M.S. and Chung, M.H.: Anthelmintic effect of trans-1, 4, 5, 6-tetrahydro-2-(3-hydrox-ystyryl)-1 -methyl pyrimidine (CP-14 445) on Trichocephalus trichiurus. Seoul Journal of Medicine 14: 228–232 (1973).
Rim, H.J.; Chang, Y.S.; Ha, J.H. and Lim, J.K.: Anthelmintic effect of oxantel pamoate (CP-14 445) against trichuriasis. Korean University Medical Journal 13: 205–211 (1976).
Rim, H.J.; Lee, J.S.; Chu, K.H.; Chang, K.H. and Lim, J.K.: Anthelmintic effect of oxantel/pyrantel tablet against intestinal nematode infections. Program and Abstracts of the 19th Annual Meeting of the Korean Society for Parasitology p.28 (1977).
Rim, H.J.; Won, C.Y.; Lee, S.I. and Lim, J.K.: Anthelmintic effect of oxantel pamoate and pyrantel pamoate suspension against intestinal nematode infections. Korean Journal of Parasitology 13: 97–101 (1975).
Seo, B.S.; Cho, S.Y.; Kang, S.Y. and Chai, J.Y.: Anthelmintic efficacy of methyl-5-benzoyl-benzimidazole-2-carbamate (mebendazole) against multiple helmintic infections. Korean Journal of Parasitology 15: 11–16 (1977).
Seo, B.S.; Rim, HJ.; Loh, I.K.; Lee, S.H.; Cho, S.Y.; Park, S.C.; Bae, J.W.; Kim, J.H.; Lee, J.S.; Koo, B.Y. and Kim, K.S.: Study on the status of helmintic infections in Koreans. Korean Journal of Parasitology 7: 53–70 (1969).
Soh, CT.; Lee, B.H.; Min, D.Y.; Chang, SJ. and Lee, J.H.: Clinical trial of ‘Vermox’ (mebendazole), a new broad-spectrum anthelmintic. Yonsei Reports on Tropical Medicine 5: 148–152 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lee, SH., Lim, JK. A Comparative Study of the Effect of Oxantel-pyrantel Suspension and Mebendazole in Mixed infections with Ascaris and Trichuris . Drugs 15 (Suppl 1), 94–98 (1978). https://doi.org/10.2165/00003495-197800151-00018
Published:
Issue Date:
DOI: https://doi.org/10.2165/00003495-197800151-00018