Skip to main content
SpringerLink
Log in

Effects of β-Adrenoreceptor Blocking Drugs on Plasma Volume, Renin and Aldosterone as Components of Their Antihypertensive Action

  • Session VI: Mode of Action of β-Adrenoreceptor Blockers in Hypertension
  • Chairman: Professor C.I. Johnston (Melbourne)
  • Published:
Drugs Aims and scope Submit manuscript

Summary

In young males with essential hypertension, propranolol and pindolol in small doses caused significant expansion of plasma volume (PV) after one month which did not prevent a reduction in BP. With higher doses, changes in PV were inconsistent and reductions in plasma renin activity (PRA) and 24- hour aldosterone excretion (AE) not closely related to BP changes. The effects of β-adrenoreceptor blocking drugs on PV, PRA and AE do not appear to be important components of their anti-hypertensive action

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bravo, E.L.; Tarazi, R.C. and Dustan, H.P.: β-adrenergic blockade in diuretic-treated patients with essential hypertension. New England Journal of Medicine 292: 66–70 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Coghlan, J.P. and Scoggins, B.A.: Measurement of aldosterone in the peripheral blood of man and sheep. Journal of Clinical Endocrinology and Metabolism 27: 1470–1486 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Gordon, R.D. and Mortimer, R.H.: Time-related aspects of arterial blood pressure, plasma volume and electrolyte homeostasis in man. International Journal of Chronobiology 1: 25–30 (1973).

    PubMed  CAS  Google Scholar 

  • Haber, E.; Koerner, R.; Page, L.B.; Kliman, B. and Purnode, A.: Application of a radioimmunoassay for angiotensin I to the physiological measurement of plasma renin activity in normal human subjects. Journal of Clinical Endocrinology and Metabolism 29: 1349–1355 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Sederberg-Olsen, P. and Ibsen, H.: Plasma volume and extracellular fluid volume during long-term treatment with propranolol in essential hypertension. Clinical Science 43: 165–170 (1972).

    PubMed  CAS  Google Scholar 

  • Tarazi, R.C; Frolich, E.D. and Dustan, H.P.: Plasma volume changes with long-term beta-adrenergic blockade. American Heart Journal 82: 770–776 (1971).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, University of Queensland, Repatriation General Hospital, Greenslopes, Brisbane, Q. 4120, Australia

    R. D. Gordon

Authors
  1. R. D. Gordon
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gordon, R.D. Effects of β-Adrenoreceptor Blocking Drugs on Plasma Volume, Renin and Aldosterone as Components of Their Antihypertensive Action. Drugs 11 (Suppl 1), 156–163 (1976). https://doi.org/10.2165/00003495-197600111-00032

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-197600111-00032

Keywords

Search

Navigation