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Haemodynamic Effects of β-Adrenoreceptor Blockers in Hypertension

  • Session VI: Mode of Action of β-Adrenoreceptor Blockers in Hypertension
  • Chairman: Professor C.I. Johnston (Melbourne)
  • Published:
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Summary

The haemodynamic effect pattern of β-blockers in hypertension is discussed. The timecurve of the antihypertensive effect differs from that of cardiac β-blockade. The antihypertensiveeffect is characterised by a slower onset at the start of treatment and a more gradualdisappearance when therapy is withdrawn. It appears that the crucial effect of β-blockers inhypertension is a gradually developing reduction in total peripheral vascular resistance. Themechanism of this apparent vasodilator action is unknown. Various possible factors involvedare mentioned. One is a reduced efficiency of transmitter release from the peripheral adrenergicneuron. Such an action may contribute to the antihypertensive effect, as fudged byresults of animal experiments described.

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Authors and Affiliations

  1. Research Laboratories, AB Hässle, Fack, S-43120, Mölndal 1, Sweden

    B. Åblad, B. Ljung & R. Sannerstedt

  2. Department of Medicine I, Sahlgrenska University Hospital, Göteborg, Sweden

    B. Åblad, B. Ljung & R. Sannerstedt

Authors
  1. B. Åblad
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  2. B. Ljung
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  3. R. Sannerstedt
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Åblad, B., Ljung, B. & Sannerstedt, R. Haemodynamic Effects of β-Adrenoreceptor Blockers in Hypertension. Drugs 11 (Suppl 1), 127–134 (1976). https://doi.org/10.2165/00003495-197600111-00028

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  • DOI: https://doi.org/10.2165/00003495-197600111-00028

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