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Hypertension and Strokes

  • Session II: Morbidity and Mortality
  • Chairman: Professor R.B. Blacket (Sydney)
  • Published:
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Summary

Strokes are the third major cause of death in developed countries and are probably the major cause of severe chronic disability. Hypertension is the most important condition predisposing to strokes, and treatment of hypertension is of great importance in stroke prevention. The relationship of strokes to the degree of hypertension, and to age, sex, race and drug treatment is discussed.

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References

  • Adams, G.F.; Exton-Smith, A.N.; Hewer, R.L. et al.: Stroke disability in Great Britain: Report of the Working Group on Strokes, Geriatrics Committee, Royal College of Physicians (Royal College of Physicians of London, London 1974).

    Google Scholar 

  • Adams, G.F. and Merrett, J.D.: Prognosis and survival in the aftermath of hemiplegia. British Medical Journal 1: 309–314 (1967).

    Article  Google Scholar 

  • Ambrose, J.: Computerized transverse axial screening (tomography): Part 2. Clinical application. British Journal of Radiology 46: 1023–1047 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Baker, H.L. Jr; Campbell, J.K.; Houser, O.W. et al.: Computer assisted tomography of the head. An early evaluation. Proceedings of the Mayo Clinic 49: 17–27 (1974).

    Google Scholar 

  • Balow, J.; Alter, M. and Resch, J.A.: Cerebral thromboembolisms. A clinical appraisal of 100 cases. Neurology 16: 559–564 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Beevers, D.G.; Hamilton, M.; Fairman, M.J. and Harpur, J.E.: Anti-hypertensive treatment and the course of established cerebral vascular disease. Lancet 1: 1407–1409 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Björk, S.; Sannerstedt, R.; Falkheden, T. et al.: The effect of active drug treatment in severe hypertensive disease: An analysis of survival rates in 381 cases on combined treatment with various hypotensive agents. Acta Medica Scandinavica 169: 673–689 (1961).

    Article  Google Scholar 

  • Breckenridge, A.; Dollery, C.T. and Parry, E.H.O.: Prognosis of treated hypertension: Changes in life expectancy and causes of death between 1962 and 1967. Quarterly Journal of Medicine 39: 411–429 (1970).

    PubMed  CAS  Google Scholar 

  • Browne, T.R. and Pozkanzer, D.C.: Treatment of strokes. New England Journal of Medicine 281: 594–602 and 650–657 (1969).

    Article  PubMed  Google Scholar 

  • Carter, A.B.: Hypotensive therapy in stroke survivors. Lancet 1: 485–489 (1969).

    Google Scholar 

  • Corbett, J.L.: Cerebral blood flow: A review; in Association of Medical Advisors to the Pharmaceutical Industry Symposium on Arteries and Veins, 1974 (Pitman, London 1975).

    Google Scholar 

  • Denny-Brown, D. and Meyer, J.S.: The cerebral collateral circulation. 2. Production of cerebral infarction by ischaemic anoxia and its reversibility in early stages. Neurology (Minneapolis) 7: 567–579 (1957).

    Article  CAS  Google Scholar 

  • Drake, W.E. and Drake, M.A.L.: Clinic and angiographie correlates of cerebrovascular insufficiency. American Journal of Medicine 45: 253–270 (1968).

    Article  PubMed  Google Scholar 

  • Farhat, S.M. and Schneider, R.C.: Observations on the effect of systemic blood pressure on intracranial circulation in patients with cerebrovascular insufficiency. Journal of Neurosurgery 27: 441–445 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Farmer, R.G.; Gifford, R.W. Jr. and Hines, E.A. Jr.: Effect of medical treatment of severe hypertension. A follow-up study of 161 patients with group 3 and group 4 hypertension. Archives of Internal Medicine 112: 118–128 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Fisher, CM.: Pathological observations in hypertensive cerebral hemorrhage. Journal of Neuropathology and Experimental Neurology 30: 536–550 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Freis, E.D. (Recorder, Veterans Administration Cooperative Study Group on Anti-hypertensive Agents): Effect of treatment on morbidity in hypertension: Results of patients with diastolic blood pressures averaging 115 through 129mm Hg. Journal of the American Medical Association 202: 116–122 (1967).

    Article  Google Scholar 

  • Freis, E.D.: (Recorder, Veterans Administration Cooperative Study Group on Anti-hypertensive Agents): The effects of treatment on morbidity in hypertension II. Results in patients with diastolic blood pressure averaging 90 through 114mm Hg. Journal of the American Medical Association 213: 1143–1152 (1970).

    Article  Google Scholar 

  • Gordon, T. and Kannel, W.B.: Predisposition to atherosclerosis in the head, heart and legs. Journal of the American Medical Association 221: 661–666 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Gormsen, J.; Dyrbye, M.; Eiken, M. et al.: Acute cerebral infarct: Extracerebral genesis with particular reference to cardiovascular status. Acta Medica Scandinavica 169: 455–466 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Graf, F.J. and Nibbelink, D.W.: Co-operative study of intracranial aneurisms and subarachnoid hemorrhage. Report on a randomized treatment study. HI. Intracranial surgery. Stroke 5: 559–601 (1974).

    Google Scholar 

  • Hamilton, M.; Thompson, E.N. and Wisniewski, T.K.M.: The role of blood pressure control in preventing complications of hypertension. Lancet 1: 235–238 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Hines, E.A. Jr.: Range of normal blood pressure and subsequent development of hypertension: A follow-up of 1,522 patients. Journal of the American Medical Association 115: 271–274 (1940).

    Article  Google Scholar 

  • Hodge, J.V.; McQueen, E.G. and Smirk, H.: Results of hypotensive therapy in arterial hypertension: Based on experience with 497 patients treated and 156 controls, observed for periods of one to eight years. British Medical Journal 1: 1–7 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Hodge, J.V. and Smirk, F.H.: The effect of drug treatment of hypertension on the distribution of deaths from various causes. American Heart Journal 73: 441–452 (1967).

    Article  Google Scholar 

  • Hoobler, S.W. (Recorder for Hypertensive Stroke Cooperative Study Group): Effect of anti-hypertensive treatment on stroke recurrence. Journal of the American Medical Association 229: 409–418 (1974).

    Article  Google Scholar 

  • Hounsfield, G.N.: Computerized transverse axial scanning (tomography) Part I. Description of system. British Journal of Radiology 46: 1016–1022 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Kannel, W.B.; Dawber, T.R.; McNamara, P.M.: Vascular disease of the brain — epidemiological aspects. The Framingham Study. American Journal of Public Health 55: 1355–1366 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Kannel, W.B.; Wolf, P.A.; Verter, J. and McNamara, P.: Epidemiological assessment of the role of blood pressure in stroke. The Framingham Study. Journal of the American Medical Association 214: 301–310 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Kendall, R.E. and Marshall, J.: Role of hypotension in the genesis of transient focal cerebral ischaemic attacks. British Medical Journal 10: 344–348 (1963).

    Article  Google Scholar 

  • Kurtzke, J.F.: in Epidemiology of Cerebrovascular Disease (Springer-Verlag, Berlin, New York 1969).

    Book  Google Scholar 

  • Leishman, A.W.D.: Merits of reducing high blood pressure. Lancet 1: 1284–1288 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Lew, E.A.: High blood pressure, other risk factors and longevity: The insurance viewpoint. The American Journal of Medicine 55: 281–294 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Lovell, R.R.H. and Prineas, R.J.: Trends in prescribing hypotensive drugs and in mortality from stroke in Australia. The Medical Journal of Australia 2: 557–560 (1971).

    PubMed  CAS  Google Scholar 

  • McMichael, J. and Murphy, E.A.: Methonium treatment of severe and malignant hypertension. Journal of Chronic Diseases 1: 527–535 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J.: A trial of long-term hypotensive therapy in cerebrovascular disease. Lancet 1: 10–12 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Matsumoto, N.; Whisnant, J.P.; Kurland, L.TV et al.: Natural history of stroke in Rochester, Minnesota, 1955 through 1969: An extension of a previous study. Stroke 4: 20–29 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Merrett, J.D. and Adams, G.F.: Comparison of mortality rates in elderly hypertensive and normotensive hemiplegic patients. British Medical Journal 2: 802–805 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Meyer, J.S.: Summary of the Seventh International Salzburg Conference on Cerebral Vascular Disease, September 25–29, 1974. Stroke 6: 109–115 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Moyer, J.M. and Brest, A.N.: The changing outlook for the patient with hypertension. American Journal of Cardiology 17: 673 (1966).

    Article  PubMed  CAS  Google Scholar 

  • New, P.F.J.; Scott, W.R.; Schnur, J.A.; Davis, K.R. and Taveras, J.M.: Computerized axial tomography with the E.M.I, scanner. Radiology 110: 109–123 (1974).

    PubMed  CAS  Google Scholar 

  • Nishioka, H.: Report of the co-operative study of intracranial aneurisms and subarachnoid hemorrhage. Section VII. 2. Hypotension and hypothermia in the treatment of intracranial aneurisms. Journal of Neurosurgery 25: 574–592 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Paulson, O.B.: Cerebral apoplexy (stroke): Pathogenesis, pathophysiology and therapy as illustrated by regional blood flow measurements in the brain. Stroke 2: 327–360 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Paxton, R. and Ambrose, J.: The E.M.I. scanner. A brief review of the first 650 patients. British Journal of Radiology 47: 530–565 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Perry, B.J. and Bridges, C: Computerized transverse axial scanning (tomography): Part 3. Radiation dose considerations. British Journal of Radiology 46: 1048–1051 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Perry, H.M. Jr.; Schroeder, H.A.; Cantanzaro, F.J. et al.: Studies on the control of hypertension. VIII. Mortality, morbidity and remissions during twelve years of intensive therapy. Circulation 33: 958–972 (1966).

    Article  PubMed  Google Scholar 

  • Hum, F.: The clinical problem: How much anoxiaischaemia damages the brain? Archives of Neurology 29: 359–360 (1973).

    Article  Google Scholar 

  • Regli, F.; Yamaguchi, T. and Waltz, A.G.: Effects of inhalation of oxygen on blood flow and microvasculature of ischaemic and non-ischaemic cerebral cortex. Stroke 1: 314–319 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Sahs, A.L.: Report of the co-operative study of intracranial aneurisms and subarachnoid hemorrhage. Section VII. 2. Hypotension and hypothermia in the treatment of intra-cranial aneurisms. Journal of Neurosurgery 25: 593–600 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Scott, W.R.; New, P.F.J.; Davis, K.R., and Schnur, J.A.: Computerized axial tomography of intracerebral and intraventricular hemorrhage. Radiology 112: 73–80 (1974).

    PubMed  CAS  Google Scholar 

  • Shafer, S.Q. and Bruun, B.: Stroke: Early portents of functional recovery in black patients. Archives of Physical and Medical Rehabilitation 55: 264–268 (1974).

    CAS  Google Scholar 

  • Shanbrom, E. and Levy, L.: The role of systemic blood pressure in cerebral circulation in carotid and basilar artery thromboses. Clinical observations and therapeutic implications of vasopressor agents. American Journal of Medicine 23: 197–204 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Shekelle, R.B.; Ostfeld, A.M. and Klawans, H.L. Jr.: Hypertension and risk of stroke in an elderly population. Stroke 5: 71–75 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Slosberg, P.: Prevention and treatment of stroke. I. Subarachnoid hemorrhage due to ruptured intracranial aneurism. New York State Journal of Medicine 73: 679–688 (1973).

    PubMed  CAS  Google Scholar 

  • Smirk, F.H. and Hodge, J.V.: Causes of death in treated hypertensive patients. Based on 82 deaths during 1959–1963 among an average hypertensive population at risk of 518 persons. British Medical Journal 2: 1221–1225 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Society of Actuaries: Build and Blood Pressure Study, Vols. I and II, Chicago (1959).

  • Stockard, J.J.; Bickford, R.G.; Myers, A.R.; Aung, M.H.; Dilley, R.B. and Schauble, J.F.: Hypotension-induced changes in cerebral function during cardiac surgery. Stroke 5: 730–746 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Strandgaard, S.; Olesen, J.; Skinhoj, E.L. and Lassen, N.A.: Autoregulation of brain circulation in severe arterial hypertension. British Medical Journal 1: 507–510 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Stuart, K.L.: Approach to assessment of risk factors in mild hypertension. British Medical Journal 2: 195–198 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Taguchi, J. and Freis, E.D.: Partial reduction of blood pressure and prevention of complications in hypertension. New England Journal of Medicine 291: 329–331 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Thompson, R.K. and Smith, G.W.: Experimental occlusion of the middle cerebral artery during arterial hypotension. Transactions of the American Neurological Association, Seventy-sixth Annual Meeting, 203–207 (1951).

  • Whisnant, J.P.; Fitzgibbons, J.P.; Kurland, L.T. and Sayre, G.P.: Natural history of stroke in Rochester, Minnesota, 1945 through 1954. Stroke 2: 11–21 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Whisnant, J.P.; Anderson, E.M.; Aronson, S.M. et al.: Report of the Joint Committee for Stroke Facilities. V. Clinical prevention of stroke. Stroke 3: 804–825 (1972).

    Google Scholar 

  • Whisnant, J.P.: Epidemiology of stroke: Emphasis on transient cerebral ischaemic attacks and hypertension. Stroke 5: 68–75 (1974).

    Article  PubMed  CAS  Google Scholar 

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  1. Neuropsychiatric Institute, P.O. Box 1, Sydney, Rozelle, NSW, 2039, Australia

    J. L. Corbett

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Corbett, J.L. Hypertension and Strokes. Drugs 11 (Suppl 1), 27–34 (1976). https://doi.org/10.2165/00003495-197600111-00010

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  • DOI: https://doi.org/10.2165/00003495-197600111-00010

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