Skip to main content
SpringerLink
Log in

Naproxen: A Review of its Pharmacological Properties and Therapeutic Efficacy and Use

  • Evaluations on New Drugs
  • Published:
Drugs Aims and scope Submit manuscript

Summary

Synopsis: Naproxen 2, (+)-6-methoxy-α-methyl-2-naphthalene acetic acid, is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, degenerative joint disease and ankylosing spondylitis.

Published data suggest that in rheumatoid arthritis, naproxen 500mg daily is comparable in efficacy with moderate doses of aspirin (3.6 to 4g daily) or 150mg daily of indomethacin, but generally causes fewer and milder side-effects than these drugs at the dosages used and can be given less frequently (12-hourly). Encouraging initial results have been reported from its use in other inflammatory joint disorders, including acute gout and juvenile rheumatoid arthritis. It has compared favourably with indomemacin in osteoarthrosis of the hip or knee. Its exact place in the management of ankylosing spondylitis remains to be determined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ansell, B.M.; Hanna, D.B. and Stoppard, M.: Naproxen absorption in children. Current Medical Research and Opinion 3: 46 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Arsenault, A.; Varady, J.; Lebel, E. and Lussier, A.: Effect of naproxen on gastro-intestinal microbleeding following acetylsalicylate medication. The Journal of Clinical Pharmacology 15: 340 (1975).

    CAS  Google Scholar 

  • Badía Flores, J.: Naproxen: Efecto ahorrador de cortico-steroides en artritis reumadoid. Scandinavian Journal of Rheumatology (Suppl. 2): 127 (1973).

  • Badia Mores, J.J. and Rojas, S.V.: Naproxen: Cortico-steroid-sparing effect in rheumatoid arthritis. The Journal of Clinical Pharmacology 15: 373 (1975).

    Google Scholar 

  • Barnes, CG; Goodman, H.V.; Eade, A.W.T.; Misra, H.N.; Cochrane, G.M.; Clarke, A.K. and Stoppard, M.: A double-blind comparison of naproxen against indomethacin in osteoarthrosis. The Journal of Clinical Pharmacology 75: 347 (1975).

    Google Scholar 

  • Beck, ER. and Hayes-Allen, M.C.: Naproxen (Naprosyn) and gastro-intestinal haemorrhage. British Medical Journal 1: 572(1974).

    Google Scholar 

  • Binzus, G. and Josenhans, G: Ergebnisse eines offenen Therapieversuches mit naproxen bei Patienten mit degenerativen Gelenkerkrankungen. Scandinavian Journal of Rheumatology (Suppl. 2): 80 (1973).

  • Borrachero, J. and Alcalde, A.: Estudio sobre la efectividad del Naproxen en la artritis reumatoidea. Scandinavian Journal of Rheumatology (Suppl. 2): 140 (1973).

  • Bowers, D.E.; Dyer, H.R.; Fosdick, WM; Keller, K.E.; Rosenberg, A.L.; Sussman, P. and Vancil, M.: A controlled trial of naproxen in rheumatoid arthritis. Annals of Internal Medicine. In press (1975).

  • Chaplin, M.D.: Lowering of plasma concentration of (+) 6-methoxyl-α-methyl-2-naphthaleneaceticacid(naproxen) by aspirin in rats. Biochemical Pharmacology 22: 1589(1973).

    Article  PubMed  CAS  Google Scholar 

  • Cochrane, G.M.: A double-blind comparison of naproxen with indomethacin in osteoarthritis. Scandinavian Journal of Rheumatology (Suppl. 2): 89 (1973).

  • Csapo, A.I.; Csapo, Elise F.; Fay, Elizabeth; Henzl, M.R. and Salau, Gabriele: The delay of spontaneous labor by naproxen in the rat model. Prostaglandins 3: 827 (1973a).

    Article  PubMed  CAS  Google Scholar 

  • Csapo, A.I.; Csapo, Elise F.; Fay, Elizabeth; Henzl, M.R. and Salau, Gabriele: The role of estradiol 17/3 in the activation of the uterus during premature labor and the effect of naproxen, an inhibitor of prostaglandin synthesis. Prostaglandins 3: 839 (1973b).

    Article  PubMed  CAS  Google Scholar 

  • Curtarelli, G. and Romussi, M.: Gastro-intestinal bleeding under treatment with naproxen. Scandinavian Journal of Rheumatology (Suppl. 2): 48 (1973).

  • Cuq, P.: Experience francaise du traitement de la crise de goutte aigue par le Naproxen — C 1674. Scandinavian Journal of Rheumatology (Suppl. 2): 64 (1973).

  • Diamond, H.; Alexander, S.; Kuzell, W.; Lussier, A.; Odone, D. and Tompkins, R.: A multi-centre double-blind crossover comparison study of naproxen and aspirin in patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology (Suppl. 2): 171 (1973).

  • Ellis, DJ. and Martin, B.: The plasma protein binding properties of a new non-steroidal antiinflammatory agent. Federation Proceedings 3: 1200(1971).

    Google Scholar 

  • Evans, F.J.: The placebo response in pain reduction. Advances in Neurology 4: 289 (1974).

    Google Scholar 

  • Ferreira, A.H.; Moncada, S. and Vane, J.R.: Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature New Biology 231: 237 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Goodman, H; Eade, A.; Misra, H.; Cochrane, G.; Clarke, A.K.; Barnes, CG. and Stoppard, M.: A double-blind comparison of naprosyn against indomethacin in osteoarthrosis; in Naprosyn in the Treatment of Rheumatic Diseases, p.38, Proceedings of a Symposium, London (Syntex, Maidenhead 1973).

    Google Scholar 

  • Halvorsen, L.; Dotevall, G. and Sevelius, H: Comparative effects of aspirin and naproxen on gastric mucosa. Scandinavian Journal of Rheumatology (Suppl. 2): 43 (1973a).

  • Halvorsen, L.; Dotevall, G. and Sevelius, H: Comparative effects of aspirin and naprosyn on gastric mucosa; in Naprosyn in the Treatment of Rheumatic Diseases, p.21, Proceedings of a Symposium, London (Syntex, Maidenhead 1973b).

    Google Scholar 

  • Harrison, LT.; Lewis, B.; Nelson, P.; Rooks, W.; Roszkowski, A.; Tomolonis, A. and Fried, J.H.: Nonsteroidal anti-inflammatory agents. I. 6-substituted 2-naphthylacetic acids. Journal of Medicinal Chemistry 13: 203–205 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Hart, F.D. and Matts, S.G.F.: Naproxen (naprosyn) and gastro-intestinal haemorrhage. British Medical Journal 2: 51(1974).

    Article  Google Scholar 

  • Haslock, D.I.; Rhymer, A.R.; Christie, G.A. and Wright, V.: A comparative trial of naproxen (naprosyn) and high dose indomethacin in rheumatoid arthritis — preliminary results; in Naprosyn in the Treatment of Rheumatic Diseases, p.35, Proceedings of a Symposium, London (Syntex, Maidenhead 1973)

    Google Scholar 

  • Hayes-Allen, M.C.: Naproxen (Naprosyn) and gastrointestinal haemorrhage. British Medical Journal 1: 572(1974).

    Article  Google Scholar 

  • Helby-Petersen, P.; Ibfelt, H and Rossel, L: A double-blind crossover comparison of naproxen and placebo in rheumatoid arthritis. Scandinavian Journal of Rheumatology (Suppl. 2): 145 (1973).

  • Hill, Hilary F.H. and Hill, A.G.S.: Naproxen in ankylosing spondylitis. Scandinavian Journal of Rheumatology (Suppl. 2): 121 (1973a).

  • Hill, Hilary F.H. and Hill, A.G.S.: Naprosyn in ankylosing spondylitis; in Naprosyn in the Treatment of Rheumatic Diseases, p.42, Proceedings of a Symposium, London (Syntex, Maidenhead 1973b).

    Google Scholar 

  • Hill, Hilary F.H; Hill, A.G.S.; Mowat, A.G.; Ansell, B.M.; Mathews, J.A.; Seifert, M.H.; Gumpel, J.M. and Christie, G.A.: Multi-centre double-blind crossover trial comparing naproxen and aspirin in rheumatoid arthritis. Scandinavian Journal of Rheumatology (Suppl. 2): 176 (1973a).

  • Hill, Hilary F.H; Hill, A.G.S.; Mowat, A.G.; Ansell, B.M.; Mathews, J.A.; Seifert, M.H. and Gumpel, J.M.: A controlled trial of naprosyn versus aspirin in rheumatoid arthritis; in Naprosyn in the Treatment of Rheumatic Diseases, p.32, Proceedings of a Symposium, London (Syntex, Maidenhead 1973b).

    Google Scholar 

  • Hill, Hilary F.H; Hill, A.G.S.; Gumpel, J.M.; Mowat, A.G.; Ansell, B.M.; Haslock, D.I. and Mathews, J.A.: Naprosyn in open study in patients intolerant of other non-steroidal anti-inflammatory agents; in Naprosyn in the Treatment of Rheumatic Diseases, p.47, Proceedings of a Symposium, London (Syntex, Maidenhead 1973c).

    Google Scholar 

  • Kageyama, T.: Clinical evaluation of naproxen in the treatment of osteoarthritis — double-blind, cross-over trial. Scandinavian Journal of Rheumatology (Suppl. 2): 94 (1973).

  • Karim, S.M.M. and Hillier, K.: Prostaglandins: Pharmacology and clinical application. Drugs 8: 176 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Katona, G: Naproxen nuevo antireumatico, no esteroideo en el tratamiento de la enfermedad articular degenerativa. Un estudio doble-ciego. Naproxen, a new non-steroidal antirheumatic in the treatment of degenerative joint disease. A double-blind study). Revista de la Facultad de ciencias medicas 15: 211–215 (1972).

    Google Scholar 

  • Katona, G.: Four years of clinical experience with naproxen and objective methods of evaluation. Scandinavian Journal of Rheumatology (Suppl. 2): 101 (1973).

  • Katona, G.; Ortega, E. and Robles-Gil, J.: The treatment of rheumatoid arthritis: a new nonsteroidal antiinflammatory drug, naproxen. Clinical Trials Journal 8: 3 (1971).

    Google Scholar 

  • Kogstad, O.: A double-blind crossover study of naproxen and indomethacin in patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology (Suppl. 2): 159 (1973).

  • Lussier, A.; Myhal, D; Boost, G.; Varady, J.; Segre, E. and Strauss, W.: Long-term study of naproxen challenged by a short-term double-blind crossover study with placebo in rheumatoid patients. Scandinavian Journal of Rheumatology (Suppl. 2): 113 (1973a).

  • Lussier, A.; Myhal, M.D. and Chamberlain, M.: Controlled studies of safety and efficacy of a new non-steroid anti-inflammatory drug; in Naprosyn in the Treatment of Rheumatic Diseases, p.53, Proceedings of a Symposium, London (Syntex, Maidenhead 1973b).

    Google Scholar 

  • Lussier, A.; Regoli, D.; Gysling, E.; Boost, G. and Varady, J.C.: Methoxypropriocin (RS-3540); clinical study on 40 patients suffering from rheumatoid arthritis. International Journal of Clinical Pharmacology 1: 6 (1973c).

    Google Scholar 

  • Lussier, A.; Segre, E.J.; Multz, CG.; MacCannell, K.L.; Alexander, S.J.; Howard, D.L.G.; Boost, G.; Varady, J. and Strauss, W.: Naproxen: A novel approach to dose-finding efficacy trials in rheumatoid arthritis. Clinical Pharmacology and Therapeutics 14: 434 (1973d).

    PubMed  CAS  Google Scholar 

  • Massey, Sue E; Varady, J.C. and Henzl, M.R.: Pain relief with naproxen following insertion of an intrauterine device. Journal of Reproductive Medicine 75: 226(1974).

    Google Scholar 

  • Mathies, H. and Wolff, E.: Steroid savings with naproxen (translation). Paper presented at an International Symposium on Naproxen, Berlin, November 7th and 8th (1974).

  • Messias, A.R.; Brito, A.S. and de Oliveira, I.L.: Clinical evaluation of d-2-(6′methoxy-2′-naphthyl) — propionic acid (naproxen) in rheumatic conditions. The Journal of Clinical Pharmacology 15: 324 (1975).

    CAS  Google Scholar 

  • Myhal, D.; Camerlain, Monique; Ménard, H. and Lussier, A.: Naproxen: long-term study in rheumatoid arthritis and ‘placebo pulse’. The Journal of Clinical Pharmacology 15: 327 (1975).

    CAS  Google Scholar 

  • Nadell, Judith; Bruno, J.; Varady, J. and Segre, E.J.: Effect of naprosyn and of aspirin on bleeding time and platelet aggregation; in Naprosyn in the Treatment of Rheumatic Diseases, p.24, Proceedings of a symposium, London (Syntex, Maidenhead 1973).

    Google Scholar 

  • Nadell, Judith; Bruno, J; Varady, J. and Segre, E.J.: Effect of naprosyn and aspirin on bleeding time and platelet aggregation. The Journal of Clinical Pharmacology 14: 176(1974).

    CAS  Google Scholar 

  • Okada, T. and Sakuma, A.: Effects of naproxen tablets on rheumatoid arthritis; in Dixon, Duizabo, Holt, Jayson and Wood XIIIth International Congress of Rheumatology, Kyoto, Japan, International Congress Series No.299. (Excerpta Medica, Amsterdam 1973).

  • D’Omézon, Y.: Etude des cliniciens français sur l’action de Naproxene dans la P.C.E. Scandinavian Journal of Rheumatology (Suppl. 2): 164 (1973).

  • Ozawa, H; Ideda, M. and Ito, N.: d-2-(6-methoxy-2-naphthyl) propionic acid (naproxen). Pharmacometrics (Tokyo) 6: 201 (1972a).

    CAS  Google Scholar 

  • Ozawa, H.; Ideda, M. and Suzuki, M.: General pharmacologic actions of naproxen on the central nervous system. Pharmacometrics (Tokyo) 6: 1039 (1972b).

    CAS  Google Scholar 

  • Pelczarska, A.B. and Roszkowski, A.P.: Inhibitors of Forssman guinea pig ‘anaphylaxis’. Journal of Pharmacology and Experimental Therapeutics 755: 116–126(1973).

    Google Scholar 

  • Peter, E. and Veress, M.: Double-blind test for the effect of naproxen and indomethacin suppositories for the post-midnight pain in Bechterew patients (translation). Paper presented at an International Symposium on Naproxen, Berlin, November 7th and 8th 1974.

  • Poal, J.; de Anta, J. and Reyes, J.: Estudio de Naproxen en osteoarthritis. Scandinavian Journal of Rheumatology (Suppl. 2): 77 (1973).

  • Reynolds, P.M.G. and Whorwell, P.J.: A single-blind comparison of fenoprofen, ibuprofen and naproxen in rheumatoid arthritis. Current Medical Research and Opinion 2: 461 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Rooks, W.; Roszkowski, A.; Tomolonis, A. and Miller, Lois M.: Pharmacological activity of naproxen in the rodent; in Naprosyn in the Treatment of Rheumatic Diseases, p.8, Proceedings of a Symposium, London (Syntex, Maidenhead 1973).

    Google Scholar 

  • Roszkowski, A.P.; Rooks, W.H.; Tomolonis, AJ. and Miller, Lois M.: Anti-inflammatory and analgesic properties of d-2-(6′methoxy-2′-naphthyl-propionic) acid (naproxen). Journal of Pharmacology and Experimental Therapeutics 779: 114 (1971).

    Google Scholar 

  • Roszkowski, A.P.; Rooks, W.; Tomolonis, A.;Miller, Lois M. and Pelczarska, A.B.: Pharmacological properties of naproxen. Scandinavian Journal of Rheumatology (Suppl. 2): 12 (1973).

  • Roth, S.H.: Safety and efficacy of naprosyn therapy in rheumatoid arthritis patients with upper gastrointestinal dysfunction; in Naprosyn in the Treatment of Rheumatic Diseases, p.50, Proceedings of a Symposium, London (Syntex, Maidenhead 1973).

    Google Scholar 

  • Roth, S.H. and Boost, G.: An open trial of naproxen in rheumatoid arthritis patients with significant esophageal, gastric and duodenal lesions. The Journal of Clinical Pharmacology 75: 378 (1975).

    Google Scholar 

  • Ruedy, J.: A comparison of the analgesic efficacy of naproxen and acetylsalicylic acid-codeine in patients with pain after dental surgery. Scandinavian Journal of Rheumatology (Suppl. 2): 60 (1973).

  • Ruedy, J. and McCullough, Wendy: A comparison of the analgesic efficacy of naproxen and propoxyphene in patients with pain after orthopedic surgery. Scandinavian Journal of Rheumatology (Suppl. 2): 56(1973).

  • Runkel, R.A.; Chaplin, M.; Boost, G; Segre, E. and Forchielli, E: Absorption, distribution, metabolism and excretion of naproxen in various laboratory animals and human subjects. Journal of Pharmaceutical Sciences 61: 703 (1972b).

    Article  PubMed  CAS  Google Scholar 

  • Runkel, R.A.; Chaplin, M.D.; Ortega, E.; Sevelius, H. and Segre, E.J.: Tolerance and pharmacokinetics following overdoses of naproxen. Clinical Pharmacology and Therapeutics (abstract) 7 7: 242 (1975).

    Google Scholar 

  • Runkel, R.; Forchielli, E.; Boost, G.; Chaplin, M.;Hill, R.; Sevelius, H; Thompson, G. and Segre, E.: Naproxen metabolism, excretion and comparative pharmacokinetics. Scandinavian Journal of Rheumatology (Suppl. 2): 29 (1973).

  • Runkel, R.A.; Forchielli, E; Sevelius, H.; Chaplin, M. and Segre, E.: Nonlinear plasma level response to high doses of naproxen. Clinical Pharmacology and Therapeutics 75: 261 (1974).

    Google Scholar 

  • Runkel, R.A.; Kraft, K.S.; Boost, G.; Sevelius, H; Forchielli, E.; Hill, R.; Magoun, R.; Szakacs, J.B. and Segre, E.: Naproxen oral absorption characteristics. Chemical and Pharmaceutical Bulletin 20: 1457 (1972a).

    Article  CAS  Google Scholar 

  • Segre, E.J.: Naprosyn metabolism in man; in Naprosyn in the Treatment of Rheumatic Diseases, p.11, Proceedings of a Symposium, London (Syntex, Maidenhead 1973a).

    Google Scholar 

  • Segre, E.J.: Efficacy of Naprosyn in rheumatoid arthritis — placebo comparisons: in Naprosyn in the Treatment of Rheumatic Diseases, p.17, Proceedings of a Symposium, London (Syntex, Maidenhead 1973b).

    Google Scholar 

  • Segre, EJ.; Chaplin, M.; Forchielli, E.; Runkel, R. and Sevelius, H.: Naproxen-aspirin interactions in man. Clinical Pharmacology and Therapeutics 75; 374 (1974b).

    Google Scholar 

  • Segre, E.J.; Sevelius, H. and Varady, J.: Effects of antacids on naproxen absorption. New England Journal of Medicine 291: 582 (1974a).

    PubMed  CAS  Google Scholar 

  • Sevelius, H; Runkel, R.; Pardo, A.; Ortega, E.; Varady, J. and Segre, E.: Naproxen Suppository: Tissue response and comparative bioavailability. European Journal of Clinical Pharmacology 6: 22 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Stetson, J.B.: The clinical testing of weak oral analgesics. Anaesthesia 29: 349 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Stetson, J.B.; Robinson, K.; Wardell, W.M. and Lasagna, L.: Analgesic activity of oral naproxen in patients with postoperative pain. Scandinavian Journal of Rheumatology (Suppl. 2): 50 (1973).

  • Szanto, E.: A double-blind comparison of naproxen and indomethacin in rheumatoid arthritis. Scandinavian Journal of Rheumatology 3. 118 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Takeguchi, C. and Sih, C.J.: A rapid spectrophotometric assay for prostaglandin synthetase: Application to the study of non-steroidal anti-inflammatory agents. Prostaglandins 2: 169–184 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Tiselius, P.: Hydroxyproline excretion in the urine as a measure of anti-inflammatory effect in rheumatic patients using naproxen. Scandinavian Journal of Rheumatology (Suppl. 2): 109 (1973).

  • Thompson, G.F. and Collins, J.M.: Urinary metabolic profiles for choosing test animals for chronic toxicity studies: Application to naproxen. Journal of Pharmaceutical Sciences 62: 937 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Tomlinson, R.V.; Ringold, HJ.; Qjureshi, M.C. and Forchielli, E: Relationship between inhibition of prostaglandin synthesis and drug efficacy: Support for the current theory on mode of action of aspirin-like drugs. Biochemical and Biophysical Research Communications 46: 552–559 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Traslosheros, J.C.: Nueva Perspectiva del Tratamiento de la Arthritis Rheumatoide Juvenil. Experienceas con ‘Naproxen’. Reporte preliminar. (Translation available). Abstract from the VIth Mexican Congress of Rheumatology (abstract No.22) Mexico City, Feb. 22nd 1974.

  • Traut, E.F. and Passarelli, E. W.: Placebos in the evaluation of treatment in rheumatic diseases. Illinois Medical Journal 775: 181 (1959).

    Google Scholar 

  • Vallado, P.F. del; Gijon Banos,J. and Alvarez, P.: Ensayo clinoco albierto con naproxen en las artropatias degenerativas (osteoartritis). Scandinavian Journal of Rheumatology (Suppl. 2): 72 (1973).

  • Vane, J.R.: Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs. Nature New Biology 231: 232 (1971).

    PubMed  CAS  Google Scholar 

  • Willkens, R.F.: Double-blind crossover trial of naproxen and placebo in patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology (Suppl. 2): 132 (1973).

  • Willkens, R.F; Case, J.B. and Huix, F.J.: The treatment of acute gout with naproxen. The Journal of Clinical Pharmacology 75: 363 (1975).

    Google Scholar 

  • Willkens, R.F. and Segre, E.J.: Combination therapy with naproxen and aspirin in rheumatoid arthritis. Submitted to Arthritis and Rheumatism (1975).

Download references

Author information

Authors and Affiliations

  1. Australasian Drug Information Services, P.O. Box 34-030, Birkenhead, Auckland 10, New Zealand

    R. N. Brogden, R. M. Finder, Phyllis R. Sawyer, T. M. Speight & G. S. Avery

Authors
  1. R. N. Brogden
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. M. Finder
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Phyllis R. Sawyer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. M. Speight
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. S. Avery
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

See subject index in each issue for further indexing terms.

‘Naprosyn’; ‘Naprosine’; ‘Naxen’; ‘Proxen’; ‘Synaxsyn’ (Syntex).

Manuscript reviewed by: B.M. Ansell, MRC, Rheumatism Unit, Canadian Red Cross Memorial Hospital, Maidenhead, England; F.D. Hart, Rheumatism Clinic, Westminster Hospital, London, England; H.F.H. Hill, Oxford Regional Rheumatic Diseases Research Centre, Stoke Mandeville Hospital, Aylesbury, England; R.G. Robinson, North Shore Medical Centre, Sydney, Australia; B.S. Rose, Rheumatologist, Waikato Hospital, Hamilton, New Zealand; J. Ruedy, Division of Clinical Pharmacology, Montreal General Hospital, Montreal, Canada; J.B. Stetson, Department of Anaesthesiology, School of Medicine and Dentistry, University of Rochester, New York, USA

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brogden, R.N., Finder, R.M., Sawyer, P.R. et al. Naproxen: A Review of its Pharmacological Properties and Therapeutic Efficacy and Use. Drugs 9, 326–363 (1975). https://doi.org/10.2165/00003495-197509050-00002

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-197509050-00002

Key words

Search

Navigation