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Drugs

, Volume 8, Issue 1, pp 1–14 | Cite as

Baclofen: A Preliminary Report of its Pharmacological Properties and Therapeutic Efficacy in Spasticity

  • R. N. Brogden
  • T. M. Speight
  • G. S. Avery
Evaluations on New Drugs

Summary

Baclofen1, a new antispasticity agent, is chemically related to gamma-aminobutyric acid (GABA), a substance which occurs in the brain. It is thought that GABA produces an inhibitory effect on spinal neurones similar to that of naturally occurring inhibitory transmitters.

Whereas diazepam, the currently most widely used drug in the treatment of spasticity, acts mainly on supraspinal pathways, baclofen acts predominantly at a spinal level where it inhibits monosynaptic and polysynaptic transmission.

Key Words

Baclofen Gamma-aminobutyric acid Sclerosis, multiple Spasticity 

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Copyright information

© Adis International Limited 1974

Authors and Affiliations

  • R. N. Brogden
    • 1
  • T. M. Speight
    • 1
  • G. S. Avery
    • 1
  1. 1.Australasian Drug Information ServicesBirkenhead, Auckland 10New Zealand

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