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β-Adrenergic Receptor Blocking Drugs in Hyperthyroidism

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Summary

β-Adrenergic receptor blockade reduces many of the clinical manifestations of hyperthyroidism particularly tachycardia and dysrhythmias. β-Adrenergic receptor blocking drugs without intrinsic sympathomimetic activity are superior to those possessing it, probably because of the increased sensitivity to adrenergic receptor stimulation which is found in this condition. However, such treatment should not be considered as a long-term substitute for specific antithyroid therapy.

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References

  • Arbab, A.G. and Turner, P.: Comparison of propranolol and LB46 (prindolol) on hyperthyroid tachycardia. Postgraduate Medical Journal 47: 329–331 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Blumenthal, M.; Davis, R. and Doe, R.P.: Carcinoid syndrome following reserpine therapy in thyrotoxicosis. Archives of Internal Medicine 116: 819–823 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Bricaire, H. and Pandos, P.: Beta blocking drugs and thyroid disease. Presse Médicale, 79: 2301–2304 (1971).

    PubMed  CAS  Google Scholar 

  • Buckle, R.M.: Treatment of thyroid crisis by beta adrenergic blockade. Acta Endocrinologia 57: 168–176 (1968).

    CAS  Google Scholar 

  • Canary, J.J.; Schaaf, M.; Duffy, B.J. and Kyle, L.H.: Effects of oral and intramuscular administration of reserpine in thyrotoxicosis. New England Journal of Medicine 257: 435–442 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Cullhed, I. and Parrow, A.: Acute hemodynamic changes following beta-adrenergic blockade in hyperthyroidism. Acta Medica Scandinavica 184: 235–239(1968).

    Article  PubMed  CAS  Google Scholar 

  • Damnos, J.; Katsilambros, N.; Papamatheou, M. and Papadoyanakis N.: The response of thyrotoxic tachycardia to trasicor, a new beta adrenergic blocking agent. Current Therapeutic Research 10: 626–630(1968).

    Google Scholar 

  • Das, G. and Krieger, M.: Treatment of thyrotoxic storm with intravenous administration of propranolol. Annals of Internal Medicine 70: 985–988 (1969).

    PubMed  CAS  Google Scholar 

  • Ekue, J.M.K.; Lowe, D.C. and Shanks, R.G.: Comparison of the effects of propranolol and MJ 1999 on cardiac β-adrenoceptors in man. British Journal of Pharmacology 38: 546–553 (1970).

    Article  CAS  Google Scholar 

  • Epstein, S. and Pimstone, B.L.: A Clinical Comparison of the short-term effects of propranolol and practolol in thyrotoxicosis. South African Medical Journal 45: 575 (1971a).

    Google Scholar 

  • Epstein, S. and Pimstone, B.: Practolol in hyperthyroid cardiac failure. South African Medical Journal 45: 812–814 (1971b).

    PubMed  CAS  Google Scholar 

  • Gaffney, T.E.; Braunwald, E. and Kahler, R.L.: Effects of guanethidine on tri-iodothyroxine induced hyperthyroidism in man. New England Journal of Medicine 265: 16–20 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Gibberd, Margaret G. and Staffurth J.S.: Oxprenolol in thyrotoxicosis. Lancet 1: 205 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, S. and Killip, T.: Catecholamine depletion in thyrotoxicosis. Effect of guanethidine on cardiovascular dynamics. Circulation 31: 219–227 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Grossman, W.; Robin, N.I.; Johnson, L.W.; Brooks, H.; Selenkow, H.A. and Dexter, L.: Effects of beta blockade on the peripheral manifestations of thyrotoxicosis. Annals of Internal Medicine 74: 875–879 (1971).

    PubMed  CAS  Google Scholar 

  • Hodden, D.R.; Lowe, D.C.; Montgomery, D.A.D.; Shanks, R.G. and Weaver, J.A.: Propranolol and radioactive iodine in the treatment of thyrotoxicosis. British Journal of Pharmacology 39: 198P (1970).

    Google Scholar 

  • Howitt, G. and Rowlands, D.J.: β sympathetic blockade in hyperthyroidism. Lancet 1: 628–631 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Hughes, G.: Management of thyrotoxic crisis with a beta-adrenergic blocking agent (pronethalol). British Journal of Clinical Practice 20: 579–581 (1966).

    PubMed  CAS  Google Scholar 

  • Johnsson, G.; Norrby, A. and Solvell, L.: Potency and time-effect relationship in man of propranolol and H56/28. Comparative studies after intravenous administration. Studies on the ratio of equipotent oral and intravenous doses. Acta Pharmacologica et Toxicologica 25 (suppl. 2): 95 (1967).

    Article  PubMed  CAS  Google Scholar 

  • McDevitt, D.G.; Shanks, R.G.; Hadden, D.R.; Montgomery, D.A.D. and Weaver, J.A.: The role of the thyroid in the control of heart-rate. Lancet 1: 998–1000(1968).

    Article  PubMed  CAS  Google Scholar 

  • Marsden, C.D.; Gimlette, T.M.D.; McAllister, R.G.; Owen, D.A. and Miller, T.N.: Effect of beta adrenergic blockade on finger tremor and Achilles reflex time in anxious and thyrotoxic patients. Acta Endocrinologica 57: 353–362 (1968).

    PubMed  CAS  Google Scholar 

  • Parsons, V. and Jewitt, D.: β-adrenergic blockade in the management of acute thyrotoxic crisis, tachycardia and arrhythmias. Postgraduate Medical Journal 43: 756–762(1967).

    Article  PubMed  CAS  Google Scholar 

  • Peltola, P.: Adrenergic sensitization induced by experimental hyperthyroidism. Acta Medica Scandinavica 140 (Suppl. 262): 34 (1951).

    Google Scholar 

  • Phillips, E.M.; Turner, P.; Houghton, J. and Ferriman, D.G.: Comparison of propranolol and Ro 3-3528 in hyperthyroid tachycardia and dysrhythmias. Postgraduate Medical Journal 49: 18–23 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Pimstone, B.: Beta-adrenergic blockade in thyrotoxicosis. South African Medical Journal 43 (Suppl. Dec): 27–29 (1969).

    Google Scholar 

  • Pimstone, B. and Joffe B.: The use and abuse of beta-adrenergic blockade in the surgery of hyperthyroidism. South African Medical Journal 44: 1059–1060(1970).

    PubMed  CAS  Google Scholar 

  • Pimstone, B.; Joffe, B.; Pimstone, N.; Bonnici, F. and Jackson, W.P.V.: Clinical response to long-term propranolol therapy in hyperthyroidism. South African Medical Journal 43: 1203–1205 (1969).

    PubMed  CAS  Google Scholar 

  • Rosenblum, H.H.; Hahn, R.G. and Levine, S.A.: Epinephrine: its effect on cardiac mechanisms in experimental hyperthyroidism and hypothyroidism. Archives of Internal Medicine 51: 279–283 (1933).

    Article  Google Scholar 

  • Runeberg, L. and Kreus, K.E.: Effect of LB46, a new beta-adrenergic antagonist in hyperthyroidism. Acta medica Scandinavica 189: 423–426 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Schneckloth, R.E.; Kurland, G.S. and Freedberg, A.S.: Effect of variation in thyroid function on the pressor response to norepinephrine in man. Metabolism 2: 546–555 (1953).

    PubMed  CAS  Google Scholar 

  • Shanks, R.G.; Lowe, D.C.; Hodden, D.R.; McDevitt, D.G. and Montgomery, D.A.D.: Controlled trial of propranolol in thyrotoxicosis. Lancet 1: 993–994 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Stout, W.D.; Wiener, L. and Cox, J.W.: Combined alpha and beta sympathetic blockade in hyperthyroidism, Annals of Internal Medicine 70: 963–970 (1969).

    PubMed  CAS  Google Scholar 

  • Turner, P.: Alprenolol and propranolol in hyperthyroid tachycardia. British Journal of Pharmacology 40: 146 (1970).

    Google Scholar 

  • Turner, P.: The role of beta-receptor antagonists in hyperthyroidism. Postgraduate Medical Journal 47 (Suppl. Jan): 97–100 (1971).

    Google Scholar 

  • Turner, P.: Adrenergic blockade in hyperthyroidism. Medicine Today 6: 76–80 (1972a).

    Google Scholar 

  • Turner, P.: The relationship between thyroid function and the effects of adrenergic stimulation and blockade. Proceedings of the 5th International Congress on Pharmacology. San Francisco. (1972b).

  • Turner, P.; Granville-Grossman, K.L. and Smart, J.V.: Effect of adrenergic receptor blockade on the tachycardia of thyrotoxicosis and anxiety state. Lancet 2: 1316–1318(1965).

    Article  PubMed  CAS  Google Scholar 

  • Turner, P. and Hill, R.C.: A comparison of three beta-adrenergic receptor blocking drugs in thyrotoxic tachycardia. Journal of Clinical Pharmacology and New Drugs 8: 268–271 (1968).

    CAS  Google Scholar 

  • Wilson, W.R.; Theilen, E.O. and Fletcher, F.W.: Pharmacodynamic effects of β-adrenergic receptor blockade in patients with hyperthyroidism. Journal of Clinical Investigation 43: 1697–1703 (1964).

    Article  PubMed  CAS  Google Scholar 

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Turner, P. β-Adrenergic Receptor Blocking Drugs in Hyperthyroidism. Drugs 7, 48–54 (1974). https://doi.org/10.2165/00003495-197407010-00004

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