Skip to main content
SpringerLink
Log in

Polypharmacy

Pharmacokinetic Perspectives

  • Leading Article
  • Published:
Clinical Pharmacokinetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Aherne GW, Piall E, Marks V, Mould G, White WF. Prolongation and enhancement of serum methotrexate concentrations by probenecid. British Medical Journal 1: 1097–1099, 1978

    Article  PubMed  CAS  Google Scholar 

  • Ashburn PE. Polypharmacy in skilled nursing facilities. Annals of Internal Medicine 118: 649–650, 1993

    PubMed  CAS  Google Scholar 

  • Anderson M, Schou JS. Safety implications of the over-the-counter availability of H2-antagonists. Drug Safety 8: 179–185, 1993

    Article  Google Scholar 

  • Banfield C, O’Reilly R, Chan E, Rowland M. Phenylbutazone interaction in man: further stereochemical and metabolic considerations. British Journal of Clinical Pharmacology 16: 669–675, 1983

    Article  PubMed  CAS  Google Scholar 

  • Blum RA, D’Andrea DT, Florentino BM, Wilton JH, Hilligoss DM, et al. Increased gastric pH and the bioavailability of fluconazole and ketoconazole. Annals of Internal Medicine 114: 755–757, 1991

    PubMed  CAS  Google Scholar 

  • Brosen K. Recent developments in hepatic drug oxidation: implications for clinical pharmacokinetics. Clinical Pharmacokinetics 18: 220–239, 1990

    Article  PubMed  CAS  Google Scholar 

  • Cadieux RJ. Drug interactions in the elderly. Postgraduate Medicine 86: 179–186, 1989

    PubMed  CAS  Google Scholar 

  • Chow YK, Hirsch MS, Merrill DP, Bechtel LJ, Eron JJ, et al. Use of evolutionary limitations of HIV-1 multidrug resistance to optimize therapy. Nature 361: 650–654, 1993

    Article  PubMed  CAS  Google Scholar 

  • Cranz H. The future of self-medication. Drugs Made in Germany 30: 14–16, 1987

    Google Scholar 

  • Dawling S, Crome P. Clinical pharmacokinetic considerations in the elderly: an update. Clinical Pharmacokinetics 17: 236–263, 1989

    Article  PubMed  CAS  Google Scholar 

  • Eraker SA, Kirscht JP, Becker MH. Understanding and improving patient compliance. Annals of Internal Medicine 100: 258–268, 1984

    PubMed  CAS  Google Scholar 

  • Gilbertson WE. The FDA’s OTC drug review. In Feldmann et al. (Eds) Handbook of nonprescription drugs, 9th ed., pp. 25–40, American Pharmaceutical Association, Washington, 1990

    Google Scholar 

  • Greenblatt RM, Hollander H, McMaster JR, Henke CJ. Polypharmacy among patients attending an AIDS clinic: utilization of prescribed, unorthodox, and investigational treatments. Journal of Acquired Immune Deficiency Syndromes 4: 136–143, 1991

    PubMed  CAS  Google Scholar 

  • Honig PK, Woosley RL, Zamani K, Conner DP, Cantilena LR. Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin. Clinical Pharmacology and Therapeutics 52: 231–238, 1992

    Article  PubMed  CAS  Google Scholar 

  • Honig PK, Wortham DC, Zamani K, Conner DP, Mullin JC, et al. Terfenadine-ketoconazole interaction: pharmacokinetic and electrocardiographic consequences. Journal of the American Medical Association 269: 1513–1518, 1993

    Article  PubMed  CAS  Google Scholar 

  • Hunt CM, Watkins PB, Saenger P, Stave GM, Barlascini N, et al. Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol. Clinical Pharmacology and Therapeutics 51: 18–23, 1992

    Article  PubMed  CAS  Google Scholar 

  • Inaba T, Jurima M, Mahon WA, Kalow W In vitro studies of two isozymes of human liver cytochrome P450. Drug Metabolism and Disposition 13: 443–448, 1985

    PubMed  CAS  Google Scholar 

  • Johnston GD, Finch MB, McNeill JA, Shanks RG. A comparison of the cardiovascular effects of (+)-sotalol and (±)-sotalol following intravenous administration in normal volunteers. British Journal of Clinical Pharmacology 20: 507–510, 1985

    Article  PubMed  CAS  Google Scholar 

  • Jones JK. Assessing potential risk of drugs: the elusive target. Annals of Internal Medicine 117: 691–692, 1992

    PubMed  CAS  Google Scholar 

  • Kassier WJ, Blanc P, Greenblatt R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Archives of Internal Medicine 151: 2281–2288, 1991

    Article  Google Scholar 

  • Kroenke K, Pinholt EM. Reducing polypharmacy in the elderly: a controlled trial of physician feedback. Journal of the American Geriatrics Society 38: 31–36, 1990

    PubMed  CAS  Google Scholar 

  • Lake KD, Nolen JG, Slaker RA, Reutzel TJ, Milfred SK, et al. Over-the-counter medications in cardiac transplant recipients: guidelines for use. DICP: Annals of Pharmacotherapy 26: 1566–1575, 1992

    CAS  Google Scholar 

  • Lindeman RD. Changes in renal function with aging: implications for treatment. Drugs and Aging 2: 423–431, 1992

    Article  PubMed  CAS  Google Scholar 

  • Lowenthal DT. Drug therapy in the elderly: special considerations. Geriatrics 42: 77–82, 1987

    PubMed  CAS  Google Scholar 

  • MacLennan WJ. The ageing society. British Journal of Hospital Medicine 39: 112–118, 1988

    PubMed  CAS  Google Scholar 

  • McGinnis LS. Alternative therapies, 1990. Cancer 67 (6S): 1788–1792, 1991

    PubMed  CAS  Google Scholar 

  • MacNeil S, Hansen-Nortey E, Paschalis C, Eastwood PR, Jenner FA. Diuretics during lithium therapy. Lancet 1: 1295–1296, 1975

    Article  PubMed  CAS  Google Scholar 

  • May FE, Stewart RB, Cluff LE. Drug interactions and multiple drug administration. Clinical Pharmacology and Therapeutics 22: 322–328, 1977

    PubMed  CAS  Google Scholar 

  • Osterlind PO, Bucht G. Drug consumption during the last decade among persons born in 1902 in Umea, Sweden: a longitudinal population study. Drugs and Aging 1: 477–486, 1991

    Article  PubMed  CAS  Google Scholar 

  • Ostrom JR, Hammarlund ER, Christensen DB, Plein JB, Kethley AJ. Medication usage in an elderly population. Medical Care 23: 157–164, 1985

    Article  PubMed  CAS  Google Scholar 

  • Peck CC, Temple R, Collins JM. Understanding consequences of concurrent therapies. Journal of the American Medical Association 269: 1550–1552, 1993

    Article  PubMed  CAS  Google Scholar 

  • Schmucker DL. Aging and drug disposition: an update. Pharmacological Reviews 37: 133–147, 1985

    PubMed  CAS  Google Scholar 

  • Soumerai SB, Avorn J. Predictors of physician prescribing change in an educational experiment to improve medication use. Medical Care 25: 210–221, 1987

    Article  PubMed  CAS  Google Scholar 

  • Steinberg JR. Prescription drug impairment in the elderly. Drug Therapy 20 (August Suppl.): 83–98, 1990

    Google Scholar 

  • Stewart RB, Yedinak KC, Ware MR. Polypharmacy in psychiatry: three case studies and methods for prevention. DICP: Annals of Pharmacotherapy 26: 529–532, 1992

    CAS  Google Scholar 

  • Sullivan AM. Jumping over the counter: Rx to OTC switch. Pharmacy Update 1: 1–13, 1990

    Google Scholar 

  • Vestal RE. Aging and determinants in hepatic drug clearance. Hepatology 9: 331–334, 1989

    Article  PubMed  CAS  Google Scholar 

  • Weisler JC. Tuberculosis: immunopathogenesis and therapy. American Journal of the Medical Sciences 305: 52–65, 1993

    Article  Google Scholar 

  • Zhou HH, Anthony LB, Wood AJJ, Wilkinson GR. Induction of polymorphic 4′-hydroxylation of S-mephenytoin by rifampicin. British Journal of Clinical Pharmacology 30: 471–475, 1990

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Clinical Pharmacology, Departments of Pharmacology and Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

    Peter K. Honig &  Louis R. Cantilena

Authors
  1. Peter K. Honig
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Louis R. Cantilena
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Honig, P.K., Cantilena, L.R. Polypharmacy. Clin. Pharmacokinet. 26, 85–90 (1994). https://doi.org/10.2165/00003088-199426020-00001

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003088-199426020-00001

Keywords

Search

Navigation