References
Anderson ET, Young LS, Hewitt WL. Simultaneous antibiotic levels in ‘breakthrough’ gram-negative rod bacteremia. American Journal of Medicine 61: 493–497, 1976
Bone RC, Fischer CJ, Clemer TP, Slotman GJ, Metz CA, et al. Sepsis syndrome: a valid clinical entity. Critical Care Medicine 17: 389–393, 1989
Bundtzen RW, Gerber AU, Cohn DL, Craig WA. Post-antibiotic suppression of bacterial growth. Reviews of Infectious Diseases 3: 28–37, 1981
Craig WA, Vogelman BS. Postantibiotic effects. Annals of Internal Medicine 106: 900–902, 1987
Daikos GL, Jackson GG, Lolans VT, Livermore DM. Adaptive resistance to aminoglycoside antibiotics from first-exposure down-regulation. Journal of Infectious Diseases 162: 414–420, 1990
De Broe ME, Verbist L, Verpooten GA. Influence of dosage schedule on renal cortical accumulation of amikacin and tobramycin in man. Journal of Antimicrobial Chemotherapy 27 (Suppl. C): 41–47, 1991
De Vries PJ, Verkooyen RP, Leguit P, Verbrugh HA. Prospective randomized study of once-daily versus thrice-daily netilmicin regimens in patients with intraabdominal infections. European Journal of Clinical Microbiology and Infectious Diseases 9: 161–168, 1990
EORTC International Antimicrobial Therapy Cooperative Group. Ceftazidime combined with a short or long course of amikacin for empirical therapy of gram-negative bacteremia in cancer patients with granulocytopenia. New England Journal of Medicine 317: 1692–1698, 1987
EORTC International Antimicrobial Therapy Cooperative Group. Single v. Multiple daily doses of amikacin combined with ceftriaxone or ceftazidime for empirical therapy of fever in granulocytopenic cancer patients. 30th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, September 29 to October 2, 1991. Abstract no. 1157, p. 292, 1991
Fan ST, Lau WY, Teoh-Chan CH, Lau KF, Mauracher EH. Once daily administration of netilmicin compared with thrice daily, both in combination with metronidazole, in gangrenous and perforated appendicitis. Journal of Antimicrobial Chemotherapy 22: 69–74, 1988
Fantin B, Ebert S, Leggett J, Vogelman B, Craig WA. Factors affecting duration of in vivo postantibiotic effect for aminoglycosides against Gram-negative bacilli. Journal of Antimicrobial Chemotherapy 27: 829–836, 1990
Frame PT, Phair JP, Watanakunakorn C, Bannister TWP. Pharmacological factors associated with gentamicin nephrotoxicity in rabbits. Journal of Infectious Diseases 135: 952–956, 1977
Gatell JM, Ferran F, Araujo V, Bonet M, Soriano E, et al. Univariate and multivariate analyses of risk factors predisposing to auditory toxicity in patients receiving aminoglycosides. Antimicrobial Agents and Chemotherapy 31: 1383–1387, 1987
Gilbert DN. Once-daily aminoglycoside therapy. Antimicrobial Agents and Chemotherapy 35: 399–405, 1991
Giuliano RA, Verpooten GA, Verbist L, Wedeen RP, De Broe ME. In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats. Journal of Pharmacology and Experimental Therapeutics 236: 470–475, 1986
Hoepelman IM, Rozenberg-Arska M, Verhoef J. Comparison of once-daily ceftriaxone with gentamicin plus cefuroxime for treatment of serious bacterial infections. Lancet 331: 1305–1309, 1988
Hollender LF, Bahnini J, De Manzini N, Lau WY, Fan ST, et al. A multicentric study of netilmicin once daily versus thrice daily in patients with appendicitis and other abdominal infections. Journal of Antimicrobial Chemotherapy 23: 773–783, 1989
Isaksson B, Nilsson L, Maller R, Sören L. Postantibiotic effect of aminoglycosides on gram-negative bacteria evaluated by a new method. Journal of Antimicrobial Chemotherapy 22: 23–33, 1988
Isaksson B, Hanberger H, Maller R, Nilsson LE, Nilsson M. Synergistic post-antibiotic effect of amikacin and β-lactam antibiotics on Enterococcus faecalis. Journal of Antimicrobial Chemotherapy 27 (Suppl. C): 9–14, 1991
Kapusnik JE, Hackbarth CJ, Chambers HF, Carpenter T, Sande MA. Single large daily dosing versus intermittent dosing of tobramicin in experimental pseudomonas pneumonia. Journal of Infectious Diseases 158: 7–12, 1988
Kovarik JM, Hoepelman IM, Verhoef J. Once-daily aminoglycoside administration: new strategies for an old drug. European Journal of Clinical Microbiology and Infectious Diseases 8: 761–769, 1989
Maller R, Isaksson B, Nilsson L, Sörén L. A study of amikacin given once versus twice daily in serious infections. Journal of Antimicrobial Chemotherapy 22: 75–79, 1988
Maller R, Ahrne H, Eilard T, Eriksson I, Lausen I, et al. Efficacy and safety of amikacin in systemic infections when given as a single daily dose or in two divided doses. Journal of Antimicrobial Chemotherapy 27 (Suppl. C): 121–128, 1991
Marik PE, Havlik I, Monteagudo FSE, Lipman J. The pharmacokinetics of amikacin in critically ill adults and paediatric patients: comparison of once- versus twice-daily dosing regimens. Journal of Antimicrobial Chemotherapy 27 (Suppl. C): 81–89, 1991
Mattie H, Craig WA, Pechère J-C. Determinants of efficacy and toxicity of aminoglycosides. Journal of Antimicrobial Chemotherapy 24: 281–293, 1989
McCormack JP, Jewesson PJ. A critical reevaluation of the therapeutic range of aminoglycosides. Clinical Infectious Diseases 14: 320–329, 1992
Meunier F, Van der Auwera P, Aoun M, Ibrahim S, Tulkens PM. Empirical antimicrobial therapy with a single dose of ceftriaxone plus amikacin in febrile granulocytopenic patients: a pilot study. Journal of Antimicrobial Chemotherapy 27 (Suppl. C): 129–139, 1991
Moore RD, Lietman PS, Smith CR. Clinical response to aminoglycoside therapy: the importance of the ratio of peak concentration to minimal inhibitory concentration. Journal of Infectious Diseases 155: 93–99, 1987
Pechère J-C, Craig WA, Meunier F. Once daily dosing of aminoglycoside: one step forward. Journal of Antimicrobial Chemotherapy 27 (Suppl. C): 149–152, 1991
Powell SH, Thompson WL, Luthe MA, Stern RC, Grossniklaus DA, et al. Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin and tobramycin. Journal of Infectious Diseases 147: 918–932, 1983
Prins JM, Büller HR, Kuijper EJ, Tange RA, Speelman P. Once versus thrice daily gentamicin in patients with serious infections. Lancet 341: 335–339, 1993
Sturm AW. Netilmicin in the treatment of gram-negative bacteremia: single daily dose versus multiple daily dosage. Journal of Infectious Diseases 159: 931–937, 1989
Ter Braak EW, De Vries PJ, Bouter KP, Van der Vegt S, Dorrestein GC, et al. Once-daily dosing regimen for aminoglycoside plus β-lactam combination therapy of serious bacterial infections: comparative trial with netilmicin and ceftriaxone. American Journal of Medicine 89: 58–66, 1990
Tulkens PM. Pharmacokinetic and toxicological evaluation of a once-daily regimen versus conventional schedules of netilmicin and amikacin. Journal of Antimicrobial Chemotherapy 27 (Suppl. C): 49–61, 1991
Verpooten GA, Giuliano RA, Verbist L, Eestermans G, De Broe ME. Once-daily dosing decreases renal accumulation of gentamicin and netilmicin. Clinical Pharmacology and Therapeutics 45: 22–27, 1989
Vogelman B, Gudmundsson S, Turnidge J, Leggett J, Craig WA. In vivo postantibiotic effect in a thigh infection in neutropenic mice. Journal of Infectious Diseases 157: 287–298, 1988
Wood CA, Norton DR, Kohlepp PW, Porter GA, Houghton DC, et al. The influence of tobramycin dosage regimen on nephrotoxicity and antibacterial efficacy in a rat model of subcutaneous abscess. Journal of Infectious Diseases 158: 13–22, 1988
Zhanel GG, Hoban DJ, Harding GKM. The postantibiotic effect: a review of in vitro and in vivo data. DICP, Annals of Pharmacotherapy 25: 153–163, 1991
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Hustinx, W.N.M., Hoepelman, I.M. Aminoglycoside Dosage Regimens. Clin. Pharmacokinet. 25, 427–432 (1993). https://doi.org/10.2165/00003088-199325060-00002
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DOI: https://doi.org/10.2165/00003088-199325060-00002