References
Bailleul C, Ropars C. Internalization of various effectors of hemoglobin in human erythrocytes. In Green & DeLoach (Eds) Advances in biosciences, Vol. 81, pp. 59–65, Pergamon Press, Oxford, 1991
Berman JD. Antileishmanial activity of red cell encapsulated drugs. In Green & DeLoach (Eds) Advances in biosciences, Vol. 81, pp. 145–152, Pergamon Press, Oxford, 1991
Beutler E, Dale GL, Guinot E, Huhl W. Enzyme replacement therapy in Gaucher’s disease: preliminary clinical trial of a new enzyme preparation. Proceedings of the National Academy of Sciences of the United States of America 74: 4620–4623, 1977
Chiarantini L, Droleskey R, Magnani M, Kirch H, DeLoach JR. Targeting of erythrocytes to cytotoxic T-cells. In Magnani & DeLoach (Eds) Advances in experimental medicine and biology, Vol. 326, pp. 257–267, Plenum Press, New York, 1992
De Flora A. The technology of carrier erythrocytes: a versatile tool for diagnosis and therapy. In Koprowsky et al. (Eds) The impact of biotechnology in diagnostics, pp. 223–236, Elsevier Science Publishers, Amsterdam, 1985
De Flora A, Benatti U, Guida L, Zocchi E. Encapsulation of adriamycin in human erythrocytes. Proceedings of the National Academy of Sciences of the United States of America 83: 7029–7033, 1986a
De Flora A, Guida L, Zocchi E, Tonetti M, Benatti U. Construction of glucose oxidase-loaded human erythrocytes: a model of oxidative cytotoxicity. Italian Journal of Biochemistry 35: 361–367, 1986b
De Flora A, Zocchi E, Guida L, Polvani C, Benatti U. Conversion of encapsulated 5-fluoro-2′deoxyuridine monophosphate to the antineoplastic drug 5-fluoro-2′deoxyuridine in human erythrocytes. Proceedings of the National Academy of Sciences of the United States of America 85: 3145–3149, 1988
DeLoach JR. Comparative encapsulation of cytosine arabinoside monophosphate in human and canine erythrocytes with in vitro efflux. Journal of Applied Biochemistry 4: 533–541, 1982
DeLoach JR. Encapsulation of exogenous agents in erythrocytes and the circulating survival of carrier erythrocytes. Journal of Applied Biochemistry 5: 149–157, 1983
DeLoach JR. Hypotonic dialysis encapsulation in erythrocytes of mammalian species. In DeLoach & Sprandel (Eds) Bibliotheca haematologica, Vol. 51, pp. 1–6, Karger, Basel, 1985
DeLoach JR, Andrews K, Kruse C. Encapsulation of human recombinant interleukin-2 into carrier erythrocytes by hypoosmotic dialysis and its subsequent biologic activity. In Green & DeLoach (Eds) Advances in biosciences, Vol. 81, pp. 59–65, Pergamon Press, Oxford, 1991
DeLoach JR, Barton C. Glutaraldeyhde treated carrier erythrocytes for organ targeting of methotrexate in dogs. American Journal of Veterinary Research 42: 971–974, 1981
DeLoach JR, Barton C. Circulating carrier erythrocytes: slow release vehicles for an antileukemic drug, cytosine arabinoside. American Journal of Veterinary Research 43: 2210–2212, 1982
DeLoach JR, Peters S, Pinkard O, Glew R, Ihler G. Effect of glutaraldehyde treatment on enzyme-loaded erythrocytes. Biochimica and Biophysica Acta 496: 507–515, 1977
DeLoach JR, Sprandel U. Red blood cells as carriers for drugs. In DeLoach & Sprandel (Eds) Bibliotheca haematologica, Vol. 51, Karger, Basel, 1985
DeLoach JR, Tagner CH, Barton C. Hepatic pharmacokinetics of glutaraldehyde treated methotrexate loaded carrier erythrocytes in dogs. Research in Experimental Medicine 183: 167–175, 1983
DeLoach JR, Wagner GG. Pharmacokinetics of tetracycline encapsulated in bovine erythrocytes. American Journal of Veterinary Research 45: 640–642, 1984
Fielding RM. Liposomal drug delivery: advantages and limitations from a clinical pharmacokinetic perspective. Clinical Pharmacokinetics 21: 155–164, 1991
Fiorelli G, Fargion S, Piperno A, Cappellini MD, Rossi F, et al. Transfusion of thalassemic patients with desferoxamine loaded standard red blood cells units. In Ropars et al. (Eds) Advances in biosciences, Vol. 67, pp. 47–54, Pergamon Press, Oxford, 1987
Green R, DeLoach JR. Resealed erythrocytes as carriers and bioreactors. In Green & DeLoach (Eds) Advances in biosciences, Vol. 81, Pergamon Press, Oxford, 1991
Hoffman JF. Physiological characteristics of human red blood cells ghosts. Journal of General Physiology 42: 9–28, 1958
Kinosita K, Tsong TY. Formation and resealing of pores of controlled sizes in human erythrocytes membrane. Nature 268: 438–440, 1977
Kitao T, Hattori K. Erythrocytes entrapment of daunomycin by amphotericin B without hemolysis. Cancer Research 40: 1351–1353, 1980
Kravtzoff R, Desbois I, Chassaigne M, Muh JP, Lamagnere JP, et al. In vivo activity of L-asparaginase entrapped into human and mouse red blood cells. In Green et al. (Eds) Advances in biosciences, Vol. 81, pp. 127–137, Pergamon Press, London, 1991
Kravtzoff R, Desbois I, Dainel C, Colombat P, Lamagnere JP, et al. Immunological response to L-asparaginase loaded into red blood cells. In Magnani & Deloach (Eds) Advances in experimental medicine and biology, Vol. 326, pp. 175–182, Plenum Press, New York, 1992
Kruse CA, Freehauf CL, Patel KR, Baldeschwidler JD. Mouse erythrocytes carriers osmotically loaded with methotrexate. Biotechnology and Applied Biochemistry 9: 123–140, 1987
Langer RS, Peppas NA. Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials 2: 201–213, 1981
Magnani M, Bianchi M, Rossi L, Stocchi V. Human red blood cells as bioreactors for the release of 2′,3′-dideoxycytidine, an inhibitor of HIV infectivity. Biochemical and Biophysical Research Communications 164: 446–452, 1989
Magnani M, DeLoach JR (Eds). Advances in experimental medicine and biology, Vol. 326, Plenum Press, New York, 1992
Magnani M, Rossi L, Brandi G, Schiavano GF, Montroni M, et al. Targeting antiretroviral nucleosides analogues in phosphorylated form to macrophages: in vitro and in vivo studies. Proceedings of the National Academy of Sciences of the United States of America 89: 6477–6481, 1992
Magnani M, Rossi L, Cucchiarini L, Fornaini G, Benatti U, et al. Improved metabolic properties of hexokinase-overloaded human erythrocytes. Biochimica et Biophysica Acta 972: 1–8, 1988
Morelli A, Benatti U, Salamino F, Sparatore B, Michetti M, et al. In vitro correction of erythrocytes glucose 6-phosphate dehydrogenase (G6PD) deficiency. Archives of Biochemistry and Biophysics 197: 543–550, 1979
Nicolau C, Teisseire BP, Ropars C, Valiez MO, Herigault RA. Incorporation of allosteric effectors of hemoglobin in red blood cells: physiological effects. In DeLoach & Sprandel (Eds) Bibliotheca haematologica, Vol. 51, pp. 92–107, Karger, Basel, 1985
Noel-Hocquet S, Jabburi S, Lazar S, Maunier JC, Guillarmet G, et al. Erythrocytes as carriers of new antiopioid prodrugs: in vitro studies. In Magnani & DeLoach (Eds) Advances in experimental medicine and biology, Vol. 326, pp. 215–221, Plenum Press, New York, 1992
Polvani C, Gasparini A, Benatti U, De Flora A, Silvestri S, et al. Murine red blood cells as efficient carriers of three bacterial antigens for the production of specific and neutralizing antibodies. Biotechnology and Applied Biochemistry 14: 347–356, 1991
Rahaman A, Trea J, Roh JK, Potkul LA, Alvord WG, et al. A phase I clinical trial and pharmacokinetic evaluation of liposome-encapsulated doxorubicin. Journal of Clinical Oncology 8: 1093–1110, 1990
Ropars C, Avenard G, Chassaigne M. Large scale entrapment of drugs into resealed red blood cells using a continuous flow dialysis system. In Green et al. (Eds) Methods in enzymology, Vol. 149, pp. 242–248, Academic Press, San Diego, 1987b
Ropars C, Chassaigne M, Nicolau C (Eds). Advances in biosciences, Vol. 67, Pergamon Press, Oxford, 1987a
Ropars C, Chassaigne M, Villeréal MC, Avenard G, Hurel C, et al. Resealed red blood cells as a new blood transfusion product. In DeLoach et al. (Eds) Bibliotheca haematologica, Vol. 51, pp. 82–91, Karger, Basel, 1985
Rossi L, Bianchi M, Fraternale A, Magnani M. Normalization of hyperglycemia in diabetic mice by enzyme-loaded erythrocytes. In Magnani & DeLoach (Eds) Advances in experimental medicine and biology, Vol. 326, pp. 183–188, Plenum Press, New York, 1992
Sigudson ER, Ridge JA, Daly JM. Intraarterial infusion of doxorubicin with degradable starch microspheres: improvement of hepatic tumor uptake. Archives of Surgery 21: 1277–1286, 1986
Sprandel U. Erythrocytes as carriers for therapeutic enzymes — an approach towards enzyme therapy in inborn errors of metabolism. In DeLoach & Sprandel (Eds) Bibliotheca haematologica, Vol. 51, pp. 7–14, Karger, Basel, 1985
Teisseire B, Ropars C, Villeréal MC, Nicolau C. Long-term physiological effects of enhanced O2 release by inositol hexaphosphateloaded erythrocytes. Proceedings of the National Academy of Sciences of the United States of America 84: 6894–6898, 1987
Tonetti M, Astroff B, Satterfield W, De Flora A, Benatti U, et al. Construction and characterization of adriamycin-loaded canine red blood cells as a potential slow delivery system. Biotechnology and Applied Biochemistry 12: 621–629, 1990
Tonetti M, Astroff B, Satterfield W, De Flora A, Benatti U, et al. Pharmacokinetic properties of doxorubicin encapsulated in glutaraldehyde treated canine erythrocytes. American Journal of Veterinary Research 52: 1630–1635, 1991a
Tonetti M, Gasparini A, Giovine M, Bini D, Mazzuccotelli A, et al. Interaction of carboplatin with human carrier erythrocytes. Biotechnology and Applied Biochemistry 15: 267–277, 1992a
Tonetti M, Polvani C, Zocchi E, Guida L, Benatti U, et al. Liver targeting of autologous erythrocytes loaded with doxorubicin. European Journal of Cancer 27: 947–948, 1991b
Tonetti M, Zocchi E, Guida L, Polvani C, Benatti U, et al. Use of glutaraldehdye treated autologous erythrocytes for hepatic targeting of doxorubicin. In Magnani & DeLoach (Eds) Advances in experimental medicine and biology, Vol. 326, pp. 307–317, Plenum Press, New York, 1992b
Turrini F, Arese P, Yuan J, Low PS. Clustering of integral membrane proteins of human erythrocytes membrane stimulates autologous IgG binding, complement deposition and phagocytosis. Journal of Biological Chemistry 266: 23611–23617, 1991
Updike SJ, Wakamiya RT. Infusion of red blood cells-loaded asparaginase in monkey. Journal of Laboratory and Clinical Medicine 101: 679–691, 1983
Weinstein J. Liposomes as drug carriers in cancer therapy. Cancer Treatment Reports 68: 127–135, 1984
Zanella A, Sabbioneda L, Rossi F, Russo V, Aguggini, et al. IHP-loaded red cells: in vitro and in vivo properties. In Green & DeLoach (Eds) Advances in biosciences, Vol. 81, pp. 219–229, Pergamon Press, Oxford, 1991
Zocchi E, Guida L, Benatti U, Canepa M, Borgiani L, et al. Hepatic or splenic targeting of carrier erythrocytes: a murine model. Biotechnology and Applied Biochemistry 9: 423–434, 1987
Zocchi E, Tonetti M, Guida L, Polvani C, Benatti U, et al. Encapsulation of doxorubicin in liver-targeted erythrocytes increases the therapeutic index of the drug in a murine metastatic model. Proceedings of the National Academy of Sciences of the United States of America 86: 2040–2044, 1989
Zocchi E, Tonetti M, Polvani C, Guida L, Benatti U, et al. In vivo liver and lung targeting of adriamycin encapsulated in glutaraldehyde-treated murine erythrocytes. Biotechnology and Applied Biochemistry 10: 555–562, 1988
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tonetti, M., De Flora, A. Carrier Erythrocytes. Clin. Pharmacokinet. 25, 351–357 (1993). https://doi.org/10.2165/00003088-199325050-00001
Published:
Issue Date:
DOI: https://doi.org/10.2165/00003088-199325050-00001