Skip to main content
Log in

Drug Concentration Monitoring

An Approach to Rational Use

  • Leading Article
  • Published:
Clinical Pharmacokinetics Aims and scope Submit manuscript

Conclusion

Drug concentration monitoring should currently be considered only as a tool to supplement clinical assessment of patient response. Consideration of appropriate drug selection, dosage and clinical monitoring of response is the most crucial component of patient therapy. Confirmation is required of the benefits of drug concentration monitoring in influencing patient outcome. Similarly, further research into methods of measuring drug concentrations at receptor sites, and the correlation of such concentration with outcome, would be a valuable addition to clinical assessment in adjusting drug therapy to achieve desirable patient outcomes. Until such data are available, only selective use of drug concentration monitoring is warranted in the appropriate clinical care of patients and to prevent inappropriate use of healthcare resources.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bauman JL, Schoen MD, Hoon TJ. Practical optimisation of antiarrhythmic drug therapy using pharmacokinetic principles. Clinical Pharmacokinetics 20: 151–166, 1991

    Article  PubMed  CAS  Google Scholar 

  • Bootman JL, Wertheimer AI, Zaske D, Rowland C. Individualizing gentamicin dosage regimens in burn patients with gramnegative septicemia: a cost-benefit analysis. Journal of Pharmaceutical Sciences 68: 267–272, 1979

    Article  PubMed  CAS  Google Scholar 

  • Echizen H, Eichelbaum M. Clinical pharmacokinetics of verapamil, nifedipine and diltiazem. Clinical Pharmacokinetics 11: 425–449, 1986

    Article  PubMed  CAS  Google Scholar 

  • McCormack JP, Jewesson PJ. A critical reevaluation of the ‘therapeutic range’ of aminoglycosides. Clinical Infectious Diseases 14: 320–339, 1992

    Article  PubMed  CAS  Google Scholar 

  • McInnes GT. The value of therapeutic drug monitoring to the practising physician — an hypothesis in need of testing. British Journal of Clinical Pharmacology 27: 281–284, 1989

    Article  PubMed  CAS  Google Scholar 

  • Oosterhuis B, Van Boxtel CJ. Kinetics of drug effects in man. Therapeutic Drug Monitoring 10: 121–132, 1988

    Article  PubMed  CAS  Google Scholar 

  • Spector R, Park GD, Johnson GF, Vesell ES. Therapeutic drug monitoring. Clinical Pharmacology and Therapeutics 43: 345–353, 1988

    Article  PubMed  CAS  Google Scholar 

  • Watson ID, Thomson AH. The value of therapeutic drug monitoring to the practising physician — an hypothesis needing sensible application! British Journal of Clinical Pharmacology 28: 619–620, 1989

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brown, G.R., Miyata, M. & McCormack, J.P. Drug Concentration Monitoring. Clin. Pharmacokinet. 24, 187–194 (1993). https://doi.org/10.2165/00003088-199324030-00001

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003088-199324030-00001

Keywords

Navigation