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Temafloxacin Does Not Potentiate the Anticoagulant Effect of Warfarin in Healthy Subjects

  • Section 2: Drug Interactions
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Summary

The potential for drug interaction between temafloxacin, a new fluorinated quinolone antibiotic, and low-intensity warfarin was studied in 10 healthy male volunteers. Warfarin was administered orally at titrated dosages to maintain the International Normalised Ratio between 1.3 and 1.7, and was kept constant during the last 4 days of the 16-day trial, when temafloxacin 600mg twice daily was coadministered. Prothrombin times during temafloxacin and warfarin administration were similar to those during warfarin alone. Thus, temafloxacin did not potentiate the anticoagulant effect of warfarin 1.5 to 5.5mg daily in healthy volunteers.

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Authors and Affiliations

  1. Abbott House, Abbott Laboratories Limited, Moorbridge Road, Maidenhead, Berkshire, SL6 8JG, England

    E. Millar, S. Coles & W. Nimmo

  2. Inveresk Clinical Research Ltd, Research Park, Riccarton, Edinburgh, Scotland

    P. Wyld

Authors
  1. E. Millar
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  2. S. Coles
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  3. P. Wyld
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  4. W. Nimmo
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Millar, E., Coles, S., Wyld, P. et al. Temafloxacin Does Not Potentiate the Anticoagulant Effect of Warfarin in Healthy Subjects. Clin. Pharmacokinet. 22 (Suppl 1), 102–106 (1992). https://doi.org/10.2165/00003088-199200221-00017

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  • DOI: https://doi.org/10.2165/00003088-199200221-00017

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