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Clinical Pharmacokinetics

, Volume 19, Issue 5, pp 416–422 | Cite as

Influence of Age on the Pharmacokinetics of Alfentanil

Gender Dependence
  • Harry J. M. Lemmens
  • Anton G. L. Burm
  • Pim J. Hennis
  • Marina P. P. R. Gladines
  • James G. Bovill
Original Research Article

Summary

Studies on the effects of age on the pharmacokinetics of alfentanil are inconclusive. A possible factor in explaining the differences between various studies could be the effect of gender. The authors studied the effects of age on the pharmacokinetics of alfentanil in female (n = 21) and male (n = 15) patients undergoing lower abdominal surgery under nitrous oxide alfentanil anaesthesia. There was a significant negative correlation (r = −0.79, p < 0.001) between plasma alfentanil clearance (CL) and age in women (<50y, median CL 24.84 L/h; >50y, median CL 14.52 L/h), but not in men (<50y, median CL 19.44 L/h; >50y, median CL 16.2 L/h). The conclusion is drawn that the effects of age on the pharmacokinetics of alfentanil are gender-dependent.

Keywords

Nitrous Oxide Sufentanil Plasma Protein Binding Alfentanil Liver Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1990

Authors and Affiliations

  • Harry J. M. Lemmens
    • 1
  • Anton G. L. Burm
    • 1
  • Pim J. Hennis
    • 1
  • Marina P. P. R. Gladines
    • 1
  • James G. Bovill
    • 1
  1. 1.Department of AnesthesiologyUniversity Hospital LeidenLeidenThe Netherlands

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