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Problems in Pharmacokinetic Investigations in Patients with HIV Infection

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References

  • Abrams DI, Kuno S, Wong R, Jeffords K, Nash M, et al. Oral dextran sulfate (UAOO1) in the treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. Annals of Internal Medicine 110: 183–188, 1989

    PubMed  CAS  Google Scholar 

  • Bach MC, Valenti AJ, Howell DA, Smith TJ. Odynophagia from aphthous ulcers of the pharynx and esophagus in the acquired immunodeficiency syndrome (AIDS). Annals of Internal Medicine 109: 338–339, 1988

    PubMed  CAS  Google Scholar 

  • Brettle RP, Jones GA, Bingham J, Spacey BEM, Weatherley B. Pharmacokinetics of zidovudine in IVDU related HIV infection. Fifth International Conference on AIDS, Montreal, Abstract no. W.B.O.3, p. 203, 1989

    Google Scholar 

  • Brockmeyer NH, Mertins L, Goos M. Effect of zidovudine with phase I and II metabolism in the liver. Fifth International Conference on AIDS, Montreal. Abstract no. M.B.P.335, p. 277, 1989

    Google Scholar 

  • Chander P, Soni A, Suri A, Bhagwat R, et al. Renal ultraslructural markers in AIDS-associated nephropathy. American Journal of Pathology 126: 513–526, 1987

    PubMed  CAS  Google Scholar 

  • Connolly GM, Shanson D, Hawkins DA, Webster JN, Gazzard BG. Non-cryptosporidial diarrhoea in human immunodeficiency virus (HIV) infected patients. Gut 30: 195–200, 1989

    Article  PubMed  CAS  Google Scholar 

  • Friedman SL, Gastrointestinal symptoms in AIDS: diagnosis, evaluation, and treatment. AIDS Clinical Care 1(3): 17–20, 1989

    Google Scholar 

  • Hagopian WA, Huseby JS. Pneumocystis hepatitis and choroiditis despite successful aerosolized pentamidine pulmonary prophylaxis. Chest 96: 949–951, 1989

    Article  PubMed  CAS  Google Scholar 

  • Janoff EN, Smith PD. Perspectives on gastrointestinal infections in AIDS. Gastroenterology Clinics of North America 17: 451–463, 1988

    PubMed  CAS  Google Scholar 

  • Koda RT, Ko RJ, Antoniskis D, Shields M, Melancon H. Effect of acetaminophen (ACET) on the pharmacokinetics of zidovudine (AZT). Fifth International Conference on AIDS, Montreal. Abstract no. W.B.O.5, p. 203, 1989

    Google Scholar 

  • Kornhauser DM, Petty BG, Hendrix CW, Woods AS, Nerhood LJ, et al. Probenecid and zidovudine metabolism. Lancet 2: 473–475, 1989

    Article  PubMed  CAS  Google Scholar 

  • Lähdevirta J, Maury CPJ, Teppo A-M, Repo H. Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. American Journal of Medicine 85: 289–291, 1988

    Article  PubMed  Google Scholar 

  • Lake-Bakaar G, Beidas S, El-Sakir R, Iyer S, Straus E. Impaired gastric acid secretion in AIDS. Abstract. Gastroenterology 92: 1488, 1987

    Google Scholar 

  • Lorentsen KJ, Hendrix CW, Collins JM, Kornhauser DM, Petty BG. Dextran sulfate is poorly absorbed after oral administration. Annals of Internal Medicine 111: 561–566, 1989

    PubMed  CAS  Google Scholar 

  • Merigan TC, Skowron G, Bozzette SA, Richman D, Uttamchandani R, et al. Circulating p24 antigen levels and responses to dideoxycytidine in human immunodeficiency virus (HIV) infections. Annals of Internal Medicine 110: 189–194, 1989

    PubMed  CAS  Google Scholar 

  • Morse GD, Olson J, Portmore A, Taylor C, et al. Pharmacokinetics of orally administered zidovudine among patients with hemophilia and asymptomatic human immunodeficiency virus (HIV) infection. Antiviral Research 11: 57–65, 1989

    Article  PubMed  CAS  Google Scholar 

  • Nelson JA, Wiley CA, Reynolds-Kohler C, Reese CE, Margaretten W, et al. Human immunodeficiency virus detected in bowel epithelium for patients with gastrointestinal symptoms. Lancet 1: 259–262, 1988

    Article  PubMed  CAS  Google Scholar 

  • NIAID. Important information on results of a controlled clinical trial of zidovudine treatment of asymptomatic HIV infection: a note to physicians. Division of AIDS, NIAID, NIH, August 31, 1989

  • Pardo Y, Aldana M, Colton RM, Fischl MA, et al. Glomerular lesions in the acquired immunodeficiency syndrome. Annals of Internal Medicine 101: 429–444, 1984

    PubMed  CAS  Google Scholar 

  • Rao TKS, Friedman EA, Nicastri AD. The types of renal disease in the acquired immunodeficiency syndrome. New England Journal of Medicine 316: 1062–1068, 1987

    Article  PubMed  CAS  Google Scholar 

  • Reddy MM, Sorrell SJ, Lange M, Grieco MH. Tumor necrosis factor and HIV P24 antigen levels in serum of HIV-infected populations. Journal of Acquired Immune Deficiency Syndromes 1: 436–440, 1988

    PubMed  CAS  Google Scholar 

  • Resnick L, Veren K, Salahuddin SZ, Tondreau S, Markham PD. Stability and inactivation of HTLV-III/LAV under clinical and laboratory environments. Journal of the American Medical Association 255: 1887–1891, 1986

    Article  PubMed  CAS  Google Scholar 

  • Rubio FR, Crews T, Garland WA, Fukuda EK. Quantification of dideoxycytidine in human plasma by gas chromatography/mass spectrometry. Biomedical and Environmental Mass Spectrometry 17: 399–404, 1988

    Article  PubMed  CAS  Google Scholar 

  • Schneiderman DJ, Arenson DM, Cello JP, Margaretten W, Weber TE. Hepatic disease in patients with the acquired immune deficiency syndrome (AIDS). Hepatology 7: 925–930, 1987

    Article  PubMed  CAS  Google Scholar 

  • Singh G, Renton KW, Stebbing N. Homogeneous interferon from E, coli depresses hepatic cytochrome P-450 and drug biotransformation. Biochemical and Biophysical Research Communications 106: 1256–1261, 1982

    Article  PubMed  CAS  Google Scholar 

  • Szebeni J, Wahl SM, Popovic M, Wahl LM, Gartner S, et al. Dipyridamole potentiates the inhibition by 3′-azido-3′-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages. Theoretical Immunology Section, National Cancer Institute, Bethesda, MD 20892. Proceedings of the National Academy of Sciences of the United States of America 86: 3842–3846, 1989

    Article  PubMed  CAS  Google Scholar 

  • Vogt MW, Hartshorn KL, Furman PA, Chou TC, Fyfe JA, et al. Ribavirin antagonizes the effect of azidothymidine on HIV replication. Science 235: 1376–1379, 1987

    Article  PubMed  CAS  Google Scholar 

  • West MA, Keller GA, Cerra FB, Simmons RL. Killed Escherichia coli stimulates macrophage-mediated alterations in hepatocellular function during in vitro coculture: a mechanism of altered liver function in sepsis. Infection and Immunity 49: 563–570, 1985

    PubMed  CAS  Google Scholar 

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Unadkat, J.D., Agosti, J.M. Problems in Pharmacokinetic Investigations in Patients with HIV Infection. Clin Pharmacokinet 19, 172–176 (1990). https://doi.org/10.2165/00003088-199019030-00002

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