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Pharmacokinetic Considerations in the Use of Newer Transdermal Formulations

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  • Clinical Pharmacokinetic Concepts
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Summary

This review addresses the pharmacokinetics and pharmacodynamics of transdermally delivered drugs. The systemic input of drugs via the skin has attracted considerable interest over the past 15 years. The early promise of the administration route has, to some extent, been realised with the approval and successful launching of transdermal formulations of hvoscine (scopolamine), glyceryl trinitrate (nitroglycerin), clonidine and oestradiol. The further application of transdermal delivery, however, will require additional effort.While other molecules (e.g. testosterone, fentanyl, nicotine) may ultimately be administered in this way, important questions pertaining to pharmacology (tolerance), toxicity (irritation, sensitisation) and dose sufficiency (penetration enhancement) remain. These problems are illustrated using information which Has been published in the literature.

Overall, while the enthusiasm for attraction and benefits of transdermal delivery remain evident, it is clear that future successes will demand a heightened level of commitment and skill from the pharmaceutical scientist.

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Authors and Affiliations

  1. Departments of Pharmacy and Pharmaceutical Chemistry, University of California, San Francisco, California, USA

    Geoffrey Ridout, GianCarlo Santus &  Richard H. Guy

  2. Syntex Research Centre, Research Park, Heriot-Watt University, Riccarton, Edinburgh, Scotland

    Geoffrey Ridout, GianCarlo Santus &  Richard H. Guy

  3. Recordati S.P.A., Via M.Civitali, Milano, Italy

    Geoffrey Ridout, GianCarlo Santus &  Richard H. Guy

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Ridout, G., Santus, G. & Guy, R.H. Pharmacokinetic Considerations in the Use of Newer Transdermal Formulations. Clin-Pharmacokinet 15, 114–131 (1988). https://doi.org/10.2165/00003088-198815020-00003

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