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Clinical Pharmacokinetics of Ketoprofen After Single Intravenous Administration as a Bolus or Infusion

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Summary

The pharmacokinetics of ketoprofen were evaluated in 29 patients suffering from acute renal colic following a single intravenous administration as a bolus or short infusion (1.5 and 2 hours), and after a loading dose and a 24-hour infusion. Serum concentrations of ketoprofen were measured by high pressure liquid chromatography. The mean (± SD) values of clinical parameters were as follows: distribution half life = 0.34 ± 0.19h; elimination half-life = 2.05 ± 0.58h; k el = 0.968 ± 0.282h −1 ; k 21 = 0.943 ± 0.425 h −1 ; k 12 = 1.004 ± 0.708 h −1 ; volume of central compartment = 5.58 ± 1.67L; volume of tissue compartment = 5.14 ± 2.12L; plasma clearance = 5.10 ± 1.14L/h. These results concur with previously published data obtained after oral or intramuscular administration.

According to clinical observations, administration of a ketoprofen bolus suppressed pain within 5 to 30 minutes; the administration of a loading dose and a 24-hour infusion is almost never followed by a recurrence of pain, and this regimen was proposed as the dosage schedule of ketoprofen to treat renal colic.

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Authors and Affiliations

  1. Laboratory of Pharmacology, and Division of Nephrology, University Hospital Center of Caen, Avenue de la Côte de Nacre, 14033, Caen Cédex, France

    Danièle Debruyne, Bruno Hurault de Ligny, Jean-Philippe Ryckelynck, Françoise Albessard & Maurice Moulin

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  1. Danièle Debruyne
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  2. Bruno Hurault de Ligny
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  3. Jean-Philippe Ryckelynck
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  4. Françoise Albessard
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  5. Maurice Moulin
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Debruyne, D., de Ligny, B.H., Ryckelynck, JP. et al. Clinical Pharmacokinetics of Ketoprofen After Single Intravenous Administration as a Bolus or Infusion. Clin-Pharmacokinet 12, 214–221 (1987). https://doi.org/10.2165/00003088-198712030-00003

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