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Plasma Concentrations of Mianserin after Single Dose and at Steady-State in Depressed Elderly Patients

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Summary

Plasma mianserin and desmethylmianserin concentrations were measured in 17 clinically depressed elderly patients after a single 30mg dose of mianserin. The patients then received mianserin 30mg daily for up to 6 weeks and the plasma concentrations were measured at weekly intervals. The relationship between concentrations of mianserin and desmethylmianserin at steady-state and at 16 and 24 hours after the single test dose was not good enough to be used for prediction of dosage requirements. Reasons for this finding are discussed.

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Authors and Affiliations

  1. Poisons Unit, Guy’s Hospital and Guy’s Department of Geriatric and General Medicine, New Cross Hospital, Avonley Road, London, SE 14 5ER, England

    Sheila Dawling, Samantha Ford, Prakash Ariyanayagam, Hugh O’Neal & Roger R. Lewis

Authors
  1. Sheila Dawling
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  2. Samantha Ford
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  3. Prakash Ariyanayagam
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  4. Hugh O’Neal
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  5. Roger R. Lewis
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Dawling, S., Ford, S., Ariyanayagam, P. et al. Plasma Concentrations of Mianserin after Single Dose and at Steady-State in Depressed Elderly Patients. Clin-Pharmacokinet 12, 73–78 (1987). https://doi.org/10.2165/00003088-198712010-00005

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  • DOI: https://doi.org/10.2165/00003088-198712010-00005

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