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Sex-Related Differences in Drug Disposition in Man

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Summary

Sex-related differences in the disposition of some analgesics, anxiolytics and hypnotics have recently been reported. With certain benzodiazepines, sex has been shown to be a more important determinant of variability in drug disposition than age, while with other benzodiazepines an age-related decline in clearance was more pronounced in men than women. In young healthy adults these sex-related differences in drug disposition were related to the phase of the menstrual cycle, oral contraceptive steroid administration, and variations in plasma concentrations of albumin, α1-acid glycoprotein, free fatty acids and sex hormones. While none of the sex-related differences so far reported necessitates the modification of a therapeutic dosage regimen, it is prudent that future protocols for pharmacokinetic studies should regard age, sex, the menstrual cycle and oral contraceptive steroids as potential sources of variability.

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  1. School of Natural Sciences, The Hatfield Polytechnic, P.O. Box 109, College Lane, Hatfield, Herts, AL10 9AB, England

    Keith Wilson

  2. Biological Sciences, The Hatfield Polytechnic, Hatfield, England

    Keith Wilson

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Wilson, K. Sex-Related Differences in Drug Disposition in Man. Clin Pharmacokinet 9, 189–202 (1984). https://doi.org/10.2165/00003088-198409030-00001

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