Skip to main content
SpringerLink
Log in

Formal Genetics of Isoniazid Metabolism in Man

  • Original Research Article
  • Published:
Clinical Pharmacokinetics Aims and scope Submit manuscript

Summary

Complex segregation analysis of the isoniazid inactivator phenotype has shown the existence of a recessive gene and a multifactorial background. The phenotype is also influenced by age, sex and weight. The relevance of these findings to the grouping of individuals into slow and rapid inactivators is stressed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bönicke, R. and Lisboa, B.P.: Über die erbbedingtheit der intraindividuellen Konstanz der Isoniazid ausscheidung beim Menshen. Naturwissenschaften 44: 314 (1957).

    Article  Google Scholar 

  • Evans, D.A.P.; Manley, K. and McKusick, V.A.: Genetic control of isoniazid metabolism in man. British Medical Journal 2: 485 (1960a).

    Article  PubMed  CAS  Google Scholar 

  • Evans, D.A.P.; Storey, P.B.; Wittstadt, F.B. and Manley, K.A.: The determination of the isoniazid inactivator phenotype. American Review of Respiratory Diseases 82: 853–861 (1960b).

    CAS  Google Scholar 

  • Evans, D.A.P.; Storey, P.B. and McKusick, V.A.: Further observations on the determination of the isoniazid inactivator phenotype. Bulletin of Johns Hopkins Hospital 108: 60–66 (1961).

    CAS  Google Scholar 

  • Knight, R.A.; Selin, J. and Harris, H.W.: Genetic factors influencing isoniazid blood levels in humans. Transactions of the 18th Conference on Chemotherapy of Tuberculosis, 52 (1959).

    Google Scholar 

  • Lalouel, J.-M. and Morton, N.E.: Complex segregation analysis with pointers. Human Heredity 31: 312–321 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Lunde, P.K.M.; Frislid, K. and Hansteen, V.: Disease and acetylation polymorphism. Clinical Pharmacokinetics 2: 182–197 (1977).

    Article  PubMed  CAS  Google Scholar 

  • MacLean, C.J.; Morton, N.E. and Lew, R.: Analysis of family resemblance. IV. Operational characteristics of segregation analysis. American Journal of Human Genetics 27: 365–384 (1975).

    PubMed  CAS  Google Scholar 

  • MacLean, C.J.; Morton, N.E.; Elston, R.C. and Yee, S.: Skewness in commingled distributions. Biometrics 32: 695–699 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Maher, J.R.; Whitney, J.M.; Chambers, J.S. and Stanonis, D.J.: The quantitative determination of isoniazid and para-aminosalicylic acid in body fluids. American Review of Tuberculosis 76: 852 (1957).

    PubMed  CAS  Google Scholar 

  • Morton, N.E. and MacLean, C.J.: Analysis of family resemblance. III. Complex segregation of quantitative traits. American Journal of Human Genetics 26: 489–503 (1974).

    PubMed  CAS  Google Scholar 

  • Morton, N.E. and Rao, D.C.: Quantitative inheritance in man; in Yearbook of Physical Anthropology 21: 12–41 (1978).

    Google Scholar 

  • Weber, W.W. and Hein, D.W.: Clinical pharmacokinetics of isoniazid. Clinical Pharmacokinetics 4: 401–422 (1979).

    Article  PubMed  CAS  Google Scholar 

  • White, T.A. and Evans, D.A.P.: The acetylation of sulfamethazine and sulfamethoxyphyridazine by human subjects. Clinical Pharmacology and Therapeutics 9: 80 (1968).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Population Genetics Laboratory, University of Hawaii, Honolulu, USA

    Lennart Iselius & D. A. P. Evans

  2. Department of Clinical Genetics, Karolinska Hospital, S-104 01, Stockholm 60, Sweden

    Lennart Iselius & D. A. P. Evans

  3. Department of Medicine, University of Liverpool, Liverpool, UK

    Lennart Iselius & D. A. P. Evans

Authors
  1. Lennart Iselius
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. A. P. Evans
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iselius, L., Evans, D.A.P. Formal Genetics of Isoniazid Metabolism in Man. Clin Pharmacokinet 8, 541–544 (1983). https://doi.org/10.2165/00003088-198308060-00005

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003088-198308060-00005

Keywords

Search

Navigation