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Gilbert’s Syndrome and Drug Metabolism

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Summary

Gilbert’s syndrome is an inherited disorder which is characterised by unconjugated hyper-bilirubinaemia. In patients with Gilbert’s syndrome, both bilirubin clearance and in vitro hepatic microsomal uridine diphosphoglucuronyl transferase (UDPGT) activity are reduced. In addition, there is evidence suggesting impaired hepatic uptake of bilirubin in Gilbert’s syndrome.

Glucuronidation of a number of substrates appears to be impaired in Gilbert’s syndrome, but the significance of the reported changes in oxidation and acetylation are less clear.

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Authors and Affiliations

  1. Department of Pharmacological Sciences, Wolfson Unit of Clinical Pharmacology, The University, Newcastle-upon-Tyne, England

    A. F. Macklon, R. L. Savage & M. D. Rawlins

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  1. A. F. Macklon
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  2. R. L. Savage
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  3. M. D. Rawlins
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Macklon, A.F., Savage, R.L. & Rawlins, M.D. Gilbert’s Syndrome and Drug Metabolism. Clin Pharmacokinet 4, 223–232 (1979). https://doi.org/10.2165/00003088-197904030-00004

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