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References
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 2002; 297: 353–6
Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 1968; 114: 797–811
Perry EK, Tomlinson BE, Blessed G, et al. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br Med J 1978; 2: 1457–9
Cummings BJ, Cotman CW. Image analysis of beta-amyloid load in Alzheimer’s disease and relation to dementia severity. Lancet 1995; 346: 1524–8
Saura CA, Chen G, Malkani S, et al. Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice. J Neurosci 2005; 25(29): 6755–64
Dewachter I, Reverse D, Caluwaerts N, et al. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. J Neurosci 2002; 22(9): 3445–53
Nunomura A, Chiba S, Lippa CF, et al. Neuronal RNA oxidation is a prominent feature of familial Alzheimer’s disease. Neurobiol Dis 2004; 17(1): 108–13
Nunomura A, Perry G, Aliev G, et al. Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 2001; 60(8): 759–67
Rottkamp CA, Atwood CS, Joseph JA, et al. The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease. Peptides 2002; 23(7): 1333–41
Lee HG, Casadesus G, Zhu X, et al. Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease. Ann NY Acad Sci 2004; 1019: 1–4
Perry G, Nunomura A, Raina AK, et al. Amyloid-beta junkies [letter]. Lancet 2000; 355(9205): 757
Smith MA, Atwood CS, Joseph JA, et al. Predicting the failure of amyloid-beta vaccine. Lancet 2002; 359(9320): 1864–5
Acknowledgements
Work in the authors’ laboratories is supported by the John Douglas French Alzheimer’s Foundation and the National Institutes of Health (AG026151). The authors have no conflicts of interest that are directly relevant to the content of this article.
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Lee, Hg., Zhu, X., Perry, G. et al. The Fallacy of Amyloid and Cognition in Alzheimer’s Disease. Drugs Aging 23, 179 (2006). https://doi.org/10.2165/00002512-200623020-00007
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DOI: https://doi.org/10.2165/00002512-200623020-00007