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Diclofenac/Hyaluronic Acid

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Abstract

  • ▲ Topical gel containing 3% diclofenac in 2.5% hyaluronic acid (HYAL CT1101) is used for the treatment of actinic keratosis.

  • ▲ In animal models, diclofenac in hyaluronic acid inhibited angiogenesis and induced neovascular regression in inflammatory tissue, and depleted substance P content in snout tissue.

  • ▲ Diclofenac delivered in hyaluronic acid appears to accumulate in the epidermis of human skin in vitro and mice in vivo.

  • ▲ Results of clinical trials indicate that topical HYAL CT1101 is effective in the treatment of actinic ker atosis. A clinical cure (all lesions fully resolved) was seen in 47% of 108 patients using HYAL CT1101 compared with 19% of patients using pla cebo after 3 months in 1 randomised, double-blind study.

  • ▲ Mild to moderate skin irritation has been reported in up to 72% of patients treated with HYAL CT1101 in clinical studies.

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References

  1. Frost CA, Green AC. Epidemiology of solar keratoses. Br J Dermatol 1994; 131: 455–64

    Article  PubMed  CAS  Google Scholar 

  2. Farmer KC, Naylor MF. Sun exposure, sunscreens, and skin cancer prevention: a year-round concern. Ann Pharmacother 1996 Jun; 30: 662–73

    PubMed  CAS  Google Scholar 

  3. Marks R, Motley RJ. Skin cancer: recognition and treatment. Drugs 1995; 50: 48–61

    Article  PubMed  CAS  Google Scholar 

  4. Noble S, Wagstaff AJ. Tretinoin: a review of its pharmacologi cal properties and clinical efficacy in the topical treatment of photodamaged skin. Drugs Aging 1995; 6: 479–96

    Article  PubMed  CAS  Google Scholar 

  5. Todd PA, Sorkin EM. Diclofenac sodium: a reappraisal of its pharmacology and pharmacokinetic properties, and therapeu tic efficacy. Drugs 1988; 35: 244–85

    Article  PubMed  CAS  Google Scholar 

  6. Davis R, Yarker YE, Goa KL. Diclofenac/Misoprostol: a review of its pharmacology and therapeutic efficacy in painful in flammatory conditions. Drugs Aging 1995; 7: 372–93

    Article  PubMed  CAS  Google Scholar 

  7. Scott JE. Hyaluronan, multum in parvo. Eur J Rheumatol Inflamm 1995; 15(1): 3–8

    Google Scholar 

  8. Sedlak BJ. Hyal Pharmaceutical looks for home run with HIT drug delivery system. Genetic Engineering News 1995; 15(15): 16–7

    Google Scholar 

  9. Alam CAS, Seed MP, Willoughby DA. Angiostasis and vascular regression in chronic granulomatous inflammation induced by diclofenac in combination with hyaluronan in mice. J Pharm Pharmacol 1995; 47: 407–11

    Article  PubMed  CAS  Google Scholar 

  10. Hall CL, Yang B, Yang X, et al. Overexpression of the hyaluronan receptor RHAMM is transforming and is also re quired for H-ras transformation. Cell 1995; 82: 1–20

    Article  Google Scholar 

  11. Gustafson S, Wikstrom T, Juhlin L. Histochemical studies of hyaluronan and the hyaluronan receptor ICAM-1 in psoriasis. Int J Tissue React 1995; 17(4): 167–73

    PubMed  CAS  Google Scholar 

  12. McCourt PAG, Ek B, Forsberg N, et al. Intercellular adhesion molecule-1 is a cell surface receptor for hyaluronan. J Biol Chem 1994; 269(48): 30081–4

    PubMed  CAS  Google Scholar 

  13. Gustafson S, Bjorkman T, Forsberg N, et al. Accessible hyaluronan receptors identical to ICAM-1 in mouse mast-cell tumours. Glycoconj J 1995; 12: 350–5

    Article  PubMed  CAS  Google Scholar 

  14. Glaser V. Cell adhesion-molecular based drugs test the wa ters in the clinical arena. Genetic Engineering News 1994; 14(20)

    Google Scholar 

  15. Freemantle C, Alam CAS, Brown JR, et al. The modulation of granulomatous tissue and tumour angiogenesis by diclofenac in combination with hyaluronan (HYAL EX-0001). Int J Tis sue React 1995; 17(4): 157–66

    CAS  Google Scholar 

  16. Moore AR, Willoughby DA. Hyaluronan as a drug delivery system for diclofenac: a hypothesis for mode of action. Int J Tissue React 1995; 17(4): 153–6

    PubMed  CAS  Google Scholar 

  17. Papworth J, Colville-Nash P, Alam C, et al. The depletion of substance P by diclofenac in the mouse. Eur J Pharmacol 1997; 325: R1–2

    Article  PubMed  CAS  Google Scholar 

  18. Brown MB, Marriott C, Martin GP. The effect of hyaluronan on the in vitro deposition of diclofenac within the skin. Int J Tissue React 1995; 17(4): 133–40

    PubMed  CAS  Google Scholar 

  19. Bennett FC, Brown MB, Marriott C, et al. The diffusion of diclofenac from hyaluronan and other polysaccharide formu lations through human skin in vitro. In: Willoughby DA, editor. Royal Society of Medicine Round Table Series. Vol. 45. London: RSM, 1996: 86–96

    Google Scholar 

  20. Lin W, Maibach HI. Percutaneous absorption of diclofenac in hyaluronic acid gel: in vitro study in human skin. In: Willoughby DA, editor. Royal Society of Medicine Round Table Series. Vol. 45. London: RSM, 1996: 167–73

    Google Scholar 

  21. Seed MP, Alam CAS, Brown J, et al. The delivery of diclofenac to pathological tissues by hyaluronan (HYAL EX-0001). In: Willoughby DA, editor. Royal Society of Medicine Round Table Series. Vol. 40. London: RSM, 1995: 74–81

    Google Scholar 

  22. Rivers JK, McLean DI. An open study to assess the efficacy and safety of topical 3% diclofenac in a 2.5% hyaluronic acid gel for the treatment of actinic keratoses. Arch Dermatol 1997; 133: 1239–42

    Article  PubMed  CAS  Google Scholar 

  23. Kay B. Positive results from pivotal US actinic keratosis trial [news release]. Mississauga, ON: Hyal Pharmaceutical Cor poration, 1996 Apr 17

    Google Scholar 

  24. McEwan LE, Smith JG. Topical diclofenac/hyaluronic acid gel in the treatment of solar keratoses. Australas J Dermatol 1997; 38: 187–9

    Article  PubMed  CAS  Google Scholar 

  25. Gebauer K, Asculai S. HYAL-CT1101: a novel topical therapy for treatment of superficial basal cell carcinoma [poster presentation]. 5th World Congress on Cancers of the Skin: Sep 21–23, 1993; Berlin

  26. Rose L. Novel topical NSAID shows promise as analgesic [poster presentation]. 7th World Congress on Pain: Aug 22–27, 1993; Paris

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Authors and Affiliations

  1. Adis International Limited, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, Auckland 10, New Zealand

    Dene C. Peters & Rachel H. Foster

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  1. Dene C. Peters
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  2. Rachel H. Foster
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Correspondence to Dene C. Peters.

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Peters, D.C., Foster, R.H. Diclofenac/Hyaluronic Acid. Drugs & Aging 14, 313–319 (1999). https://doi.org/10.2165/00002512-199914040-00006

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