Summary
Geriatric failure to thrive (GFTT) is a syndrome associated with functional decline, depression and malnutrition. Adverse drug reactions are cited as one of the most common causes of GFTT. Two distinct drug-related issues should be considered. Firstly, failure to provide appropriate treatment for conditions such as anaemia, depression, nutritional deficiencies and pain may precipitate GFTT. Secondly, drug-induced functional decline and decreased nutrient intake may cause or contribute to the syndrome. Pharmacological intervention may include discontinuing potentially offending agents for a trial period, or drug treatment of anorexia and depression.
Similar content being viewed by others
References
Palmer RM. ‘Failure to thrive’ in the elderly: diagnosis and management. Geriatrics 1990 Sep; 45(9): 47–55
Braun JV, Wykle MH, Cowling WR. Failure to thrive in older persons: a concept derived. Gerontologist 1988 Dec; 28(6): 809–12
Groom DD. Elder care: a diagnostic model for failure to thrive. J Gerontol Nurs 1993 Jun; 19(6): 12–6
Newbern VB, Krowchuk HV. Failure to thrive in elderly people: a conceptual analysis. J Adv Nurs 1994 May; 19(5): 840–9
Berkman B, Foster LW, Campion E. Failure to thrive: paradigm for the frail elder. Gerontologist 1989 Oct; 29(5): 654–9
Osato EE, Stone JT, Phillips SL, et al. Clinical manifestations: failure to thrive in the elderly. J Gerontol Nurs 1993 Aug; 19(8): 28–34
Egbert AM. ‘The dwindle’: failure to thrive in older patients. Postgrad Med 1993 Oct; 94(5): 199–212
Beard K. Adverse reactions as a cause of hospital admissions in the aged. Drugs Aging 1992; 2(4): 356–67
Nolan L, O’Malley K. Prescribing for the elderly: part 1. Sensitivity of the elderly to adverse drug reactions. J Am Geriatr Soc 1988 Feb; 36(2): 142–9
Butler RN, Rinkel SI, Lewis MI, et al. Aging and mental health: diagnosis of dementia and depression. Geriatrics 1992 Jun; 47(6): 55–7
Kafonek S, Ettinger WH, Roca R, et al. Instruments for screening for depression and dementia in a long-term care facility. J Am Geriatr Soc 1989 Jan; 37(1): 29–34
Verdery RB. Failure to thrive. In: Hazzard W, Bierman EL, Blass JP, et al., editors. Principles of geriatric medicine and gerontology. 3rd ed. New York: McGraw-Hill, 1994: 1205–11
Robbins LJ. Evaluation of weight loss in the elderly. Geriatrics 1989 Apr; 44(4): 31–7
Verdery RB. ‘Wasting away’ of the old old: can it — and should it — be treated? Geriatrics 1990 Jun; 45(6): 26–31
Massachusetts Dietetic Association. Nutrition services improve health and save money: evidence from Massachusetts. Massachusetts Dietetic Association, 1993
Reilly Jr JJ, Hull SF, Albert N, et al. Economic impact of malnutrition: a model system for hospitalized patients. J Parenter Enter Nutr 1988; 12(4): 371–6
Rabinovitz M, Pitlik SD, Leifer M, et al. Unintentional weight loss: a retrospective analysis of 154 cases. Arch Intern Med 1986 Jan; 146(1): 186–7
Marton KI, Sox HC, Krupp JR. Involuntary weight loss: diagnostic and prognostic significance. Ann Intern Med 1981 Nov; 95(5): 568–74
Dukes MNG, editor. Meyler’s side effects of drugs. 12th ed. New York: Elsevier, 1992
‘DRUGDEX’ (computerized information systems for medicine and industry). Denver: Micromedex Inc., 1996 (Health Care Series for Windows)
Klein S, Iber FL. Alcoholism and associated malnutrition in the elderly. Nutrition 1991 Mar–Apr; 7(2): 75–9
Roe DA. Drug and food interactions as they affect the nutrition of older individuals. Aging 1993 Apr; 5(2 Suppl. 1): 51–3
McElroy SE, Keck PE, Friedman LM. Minimizing and managing antidepressant side effects. J Clin Psychiatry 1995; 56 Suppl. 2: 49–55
Yarasheski KE, Zachwieja JJ. Growth hormone therapy for the elderly: the fountain of youth proves toxic [letter]. JAMA 1993 Oct; 270(14): 1694
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Carr-Lopez, S.M., Phillips, S.L. The Role of Medications in Geriatric Failure to Thrive. Drugs & Aging 9, 221–225 (1996). https://doi.org/10.2165/00002512-199609040-00001
Published:
Issue Date:
DOI: https://doi.org/10.2165/00002512-199609040-00001