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Unoprostone (Isopropyl Unoprostone)

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An Erratum to this article was published on 01 November 1996

Summary

  • ▲ Unoprostone (isopropyl unoprostone) is a docosanoid compound which is related to a metabolite of prostaglandin (PG)F2α. Unoprostone has oculo-hypotensive effects.

  • ▲ The drug is thought to lower intraocular pressure (IOP) by increasing aqueous humour outflow. Aqueous humour production remains unaffected.

  • ▲ Marked reductions in IOP have been demonstrated in healthy volunteers and patients with glaucoma or ocular hypertension after instillation of unoprostone 0.12%.

  • ▲ Unoprostone 0.12% appears to have similar efficacy to timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension.

  • ▲ In phase II and III clinical studies, adverse events observed with unoprostone were predominantly local; systemic effects occurred less frequently.

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Authors and Affiliations

  1. Adis International Limited, Private Bag 65901, 41 Centorian Drive, Mairangi Bay, Auckland 10, New Zealand

    Malini Haria & Caroline M. Spencer

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  1. Malini Haria
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  2. Caroline M. Spencer
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Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/BF03257459.

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Haria, M., Spencer, C.M. Unoprostone (Isopropyl Unoprostone). Drugs & Aging 9, 213–218 (1996). https://doi.org/10.2165/00002512-199609030-00007

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  • DOI: https://doi.org/10.2165/00002512-199609030-00007

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