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Skin Growths in the Aged

Treatment Considerations

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  • Drug Therapy
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Summary

Skin disorders are very common among elderly people. All physicians who care for this population should possess the ability to recognise common benign growths. Primary care physicians should also have the ability to recognise premalignant and malignant lesions, so that early diagnosis and treatment is possible.

It is puzzling that the organ system most amenable to examination is so often overlooked in routine examinations. By simply taking the time to perform a skin examination, morbidity and mortality can be decreased.

Through improvements in pharmacotherapy, particularly the development of more effective sunscreens, it may eventually be possible to markedly reduce the development of many benign and malignant skin lesions.

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References

  • Algra JR, Knox JM. Topical photoprotective agents. International Journal of Dermatology 17: 628–637, 1978

    PubMed  CAS  Google Scholar 

  • Balch CM. Clinical management of cutaneous melanoma. In McKenna & Murphy (Eds) Fundamentals of surgical oncology, pp. 420–439, Macmillan Publishing Company, New York, 1986

    Google Scholar 

  • Bennett RG (Ed.). Fundamentals of cutaneous surgery, pp. 26–49, CV Mosby Company, St. Louis, 1988

    Google Scholar 

  • Braun-Falco O, Schoefinius HH. Lentigo Senilis. Hautarzt 22: 277–283, 1971

    PubMed  CAS  Google Scholar 

  • Carter DM. Basal Cell Carcinoma. In Fitzpatrick, et al. (Eds) Dermatology in general medicine, 3rd ed., pp. 868–921, McGraw-Hill Book Company, New York, 1987

    Google Scholar 

  • Dhingra K, Papadopoulos N, Lippman S, Lotan R, Legha SS. Phase II study of alpha-interferon and 13-cis-retinoic acid in metastatic melanoma. Investigational New Drugs 11(1): 39–43, 1993

    Article  PubMed  CAS  Google Scholar 

  • Federal Register. Sunscreen drug products for over the counter human drugs; proposed safety, effective, and labeling conditions. Washington, DC, Department of Health, Education and Welfare, Food and Drug Administration, vol 43, no. 166, p. 38206–38251, August 25, 1978

  • Fitzpatrick TB, Szabo G, Vicks J. Age changes in the human melanocyte system. In Montagna W (Ed.) Advances in the biology of the skin, pp. 56–92, Pergamon Press, Oxford, 1965

    Google Scholar 

  • Frierson Jr JF, Cooper PH. Prognostic factors in squamous cell carcinoma of the lower lip. Human Pathology 17: 346–354, 1986

    Article  PubMed  Google Scholar 

  • Gilchrest BA, Blog FB, Szabo G. The effects of aging and chronic ultraviolet irradiation on melanocytes in human skin. Journal of Investigative Dermatology 52: 141–153, 1979

    Article  Google Scholar 

  • Gilchrest BA (Ed.). Skin and aging processes, pp.67–81, CRC Press Inc., Boca Raton, 1984

    Google Scholar 

  • Glass AG, Hoover RN. The emerging epidemic of melanoma and squamous cell skin cancer. Journal of the American Medical Association 262: 2097–2100, 1989

    Article  PubMed  CAS  Google Scholar 

  • Johnson MLT. Skin conditions and related need for medical care among persons 1–74 years. United States, 1971–74. Vital and Health Statistics: Series 11. Rate from the National Health Survey, No. 212. DHEW publication No. (PHS) 79-1660, Hyattsville, Maryland, US Dept. of Health, Education, and Welfare, 1978

    Google Scholar 

  • Kaidbey KH, Kligman AM. Laboratory methods for appraising the efficacy of sunscreens. Journal of Society of Cosmetic Chemists 29: 525–532, 1978

    CAS  Google Scholar 

  • Keogh FY, Walsh RJ. Rate of greying of human hair. Nature 207: 877–882, 1965

    Article  PubMed  CAS  Google Scholar 

  • Knox JM, Smith BA, Cohen MC. Benzophenones: ultraviolet light-absorbing agents. Journal of Investigative Dermatology 29: 435–441, 1957

    PubMed  CAS  Google Scholar 

  • Koh HK. Cutaneous melanoma. New England Journal of Medicine 325: 171–190, 1991

    Article  PubMed  CAS  Google Scholar 

  • Lamy PR. Institutionalisation and drug use in older adults in the US. Drugs & Aging 3: 232–237, 1993

    Article  CAS  Google Scholar 

  • Lavker RM, Kwong F, Kligman AM. Changes in skin surface patterns with age. Journal of Gerontology 35: 348–361, 1980

    PubMed  CAS  Google Scholar 

  • Lever WF, Shaumburg-Lever G (Eds). Histopathology of the skin, 7th ed., pp. 184–207, J.B. Lippincott Company, Philadelphia, 1990

    Google Scholar 

  • Lund HZ. How often does SCC of the skin metastasize? Archives of Dermatology 92: 635–637, 1965

    Article  PubMed  CAS  Google Scholar 

  • MacKie RM. Tumours of the skin. In Rook A et al. (Eds) Textbook of dermatology, 4th ed., pp. 442–460, Blackwell Scientific Publications, Oxford, 1986

    Google Scholar 

  • Marks R, Foley P, Goodman G, et al. Spontaneous remission of solar keratoses: the case for conservative management. British Journal of Dermatology 115: 649–655, 1986

    Article  PubMed  CAS  Google Scholar 

  • Marks R, Ponsford MW, Selwood TS, Goodman G, Mason G. Nonmelanocytic skin cancer and solar keratosis in Victoria. Medical Journal of Australia 2: 619–622, 1983

    PubMed  CAS  Google Scholar 

  • Mitchell MS, Harel W, Kan-Mitchell J, LeMay LG, Goedegebuure P, et al. Active specific immunotherapy of melanoma with allogeneic cell lysates. Rationale, results, and possible mechanisms of action. Annals of the New York Academy of Science 690: 153–166, 1993

    Article  CAS  Google Scholar 

  • Mitchell MS, Harel W, Kempf RA, Hu E, Kan-Mitchell J, et al. Active-specific immunotherapy for melanoma. Journal of Clinical Oncology 8(5): 856–869, 1990

    PubMed  CAS  Google Scholar 

  • Montagna W, Carlisle K. Structural changes in aging human skin. Journal of Investigative Dermatology 73: 47, 1979

    Article  PubMed  CAS  Google Scholar 

  • National Cancer Institutes. Cancer statistics review. 1973–1987. Department of Health and Human Services, NIH Publication no. 90-2788, Bethesda, 1990

    Google Scholar 

  • Ogasawara M, Rosenberg SA. Enhanced expression of HLA molecules and stimulation of autologous human tumor infiltrating lymphocytes following transduction of melanoma cells with gamma-interferon genes. Cancer Research 53(15): 3561–3568, 1993

    PubMed  CAS  Google Scholar 

  • Parrish JA. The scope of photomedicine. In Regan & Parrish (Eds) The science of photomedicine, pp. 3–12, Plenum Press, New York, 1982

    Chapter  Google Scholar 

  • Pathak MA. Sunscreens topical and systemic approaches for protection of human skin against harmful effects of solar radiation. Journal of the American Academy of Dermatology 1: 285–292, 1982

    Article  Google Scholar 

  • Pathak MA, Fitzpatrick TB, Kraus EW, et al. Topical and systemic approaches to protection of human skin against harmful effects of solar radiation. In Regan & Parrish (Eds) The science of photomedicine, p.441, Plenum Press, New York, 1983

    Google Scholar 

  • Phillips TJ, Dover JS. Leg ulcers. Journal of the American Academy of Dermatology 25: 965–987, 1991

    Article  PubMed  CAS  Google Scholar 

  • Quevdo WC, Szabo G, Vicks J. Influence of age and UV on the population of dopa-positive melanocytes in human skin. Journal of Investigative Dermatology 52: 287–294, 1969

    Google Scholar 

  • Rhodes AR. Neoplasms: benign neoplasms, hyperplasias, and dysplasias of melanocytes. In Fitzpatrick, et al. (Eds) Dermatology in general medicine, 3rd ed., pp. 355–371, McGraw-Hill Book Company, New York, 1987

    Google Scholar 

  • Rigel DS, Kopf AW, Friedman RJ. The rate of malignant melanoma in the United States: are we making an impact? Journal of the American Academy of Dermatology 17: 1050–1053, 1987

    Article  PubMed  CAS  Google Scholar 

  • Rogers GS. Surgical management of malignant melanoma. Dermatology Clinics of North America 9: 649–656, 1991

    CAS  Google Scholar 

  • Rogers GS, Gilchrest BA. Environmental influences on skin aging and cutaneous carcinogenesis. In Cooper et al. (Eds), Aging and environmental toxicology, Johns Hopkins University Press, Baltimore, 1991

    Google Scholar 

  • Rowe DE, Carroll RJ, Day CL. Long-term recurrence rates in previously untreated (primary) basal cell carcinoma: implications for patient follow-up. Journal of Dermatologic Surgery and Oncology 15: 3–11, 1989

    Google Scholar 

  • Samson MK, Haas CD, Baker LA, Cummings G. Dibromodulcitol (DBD), DTIC and actinomycin-D in disseminated malignant melanoma. A phase I–II clinical trial. American Journal of Clinical Oncology 8(2): 167–171, 1985

    Article  PubMed  CAS  Google Scholar 

  • Sayre RM, Duncan P. The correlation of indoor solar simulator and natural sunlight testing of sunscreen products. Archives of Dermatology 114: 1649–1655, 1978

    Article  PubMed  CAS  Google Scholar 

  • Sedlin ED, Fleming JL. Epidermal carcinoma arising in chronic osteomyelitis foci. Journal of Bone and Joint Surgery — British volume 45: 827–837, 1963

    Google Scholar 

  • Tindall JP, Smith JG. Skin lesions of the aged. Journal of the American Medical Association 186: 1039–1046, 1963

    Article  PubMed  CAS  Google Scholar 

  • Toby AC, Mathias CG, Rollins D, Lo HG. Allergic contact photodermatitis to paraminobenzoic acid. Archives of Dermatology 114: 1665–1671, 1978

    Article  Google Scholar 

  • Tuttle MS, Caldwell TM, Taylor HW, et al. Judging prognosis in lentigo maligna melanoma. Annals of Surgery 198: 200–206, 1984

    Google Scholar 

  • US Bureau of the Census, Current Population Reports, Series P-25, No. 922: Decennial Census of Population 1900–1983 and Projection of the Population of the US, 1982–2050, Washington, 1982

Download references

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Frank, W., Rogers, G.S. Skin Growths in the Aged. Drugs & Aging 4, 194–206 (1994). https://doi.org/10.2165/00002512-199404030-00003

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