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Is the Use of Chemotherapy Justified in Non-Small-Cell Lung Cancer?

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References

  • American Thoracic Society Statement. Clinical staging of Primary Lung Cancer — official American Thoracic Society Statement November 1981. American Review of Respiratory Disease 127: 1, May 1983

  • Bunn Jr PA. The expanding role of cisplatin in the treatment of non small cell lung cancer. Seminars in Oncology 16 (Suppl. 6): 10–21, 1989

    PubMed  Google Scholar 

  • Callahan D. Setting Limits. Simon and Schuster, New York, 1987

    Google Scholar 

  • Cellerino R, Tummarello D, Guidi F, Isidori P, Raspugli M, et al. A randomised trial of alternating chemotherapy versus best supportive care in advanced non small cell lung cancer. Journal of Clinical Oncology 9: 1453–1461, 1991

    PubMed  CAS  Google Scholar 

  • Davis F, Pandya MR, Rambotti P. Single agent and combination chemotherapy for extensive non small cell carcinomas of the lung. Cancer Treatment Reports 64: 685–688, 1980

    PubMed  CAS  Google Scholar 

  • Davis S, Rambotti P, Parke YK. Combination cyclophosphamide, doxorubicin and cisplatin (CAO) chemotherapy for extensive non small cell carcinoma of the lung. Cancer Treatment Reports 65: 955–958, 1981

    PubMed  CAS  Google Scholar 

  • DeVore R, Hainsworth JD, Greco FA, Hande K, Johnson D. Chronic oral etoposide in the treatment of lung cancer. Seminars in Oncology 19 (6, Suppl. 14): 28–35, 1992

    PubMed  CAS  Google Scholar 

  • Dillman RO, Seagren SL, Propert KJ, Guerra J, Eaton WL. A randomised trial of induction chemotherapy plus high dose radiation versus radiation alone in Stage III non small cell lung cancer. New England Journal of Medicine 323: 940–945, 1990

    Article  PubMed  CAS  Google Scholar 

  • Donnadieu N, Paesmans M, Sculier JP. Chemotherapy of non small cell lung cancer according to disease extent: a meta analysis of the literature. Lung Cancer 7: 243–252, 1991

    Article  Google Scholar 

  • Durrant KR, Berry RJ, Ellis F, Ridehalgh FR, Black JM, et al. Comparison of treatment policies in inoperable bronchial carcinoma. Lancet 1: 715–719, 1971

    Article  PubMed  CAS  Google Scholar 

  • Einhorn LH, Williams SD, Stevens EE, Bond WH, Chenoweth L. Random prospective study of cyclophosphamide, doxorubicin and methotrexate (CAM) combination chemotherapy versus single agent sequential chemotherapy in non small cell lung cancer. Cancer Treatment Reports 66: 2005–2011, 1982

    PubMed  CAS  Google Scholar 

  • Elliott JA, Ahmedzai S, Hole D, Dorword AJ, Stevenson RD, et al. Vindesine and cisplatin combination chemotherapy compared with vindesine as a single agent in the management of non small cell lung cancer: a randomised study. European Journal of Clinical Oncology 20: 1025–1032, 1984

    Article  CAS  Google Scholar 

  • Feld R, Rubinstein LV, Weisenberger TH. Sites of recurrence in resected stage I non small cell lung cancer: a guide for future studies. Journal of Clinical Oncology 2: 1352–1358, 1984

    PubMed  CAS  Google Scholar 

  • Fentiman IS, Tirelli U, Morfardini S, Schneider M, Festen J, et al. Cancer in the Elderly: Why so badly treated?. Lancet 335: 1020–1022, 1990

    Article  PubMed  CAS  Google Scholar 

  • Finkelstein DM, Ettinger DS, Ruckdeschel JC. Long term survivors of metastatic non small cell lung cancer: an Eastern Cooperative Oncology Group study. Journal of Clinical Oncology 4: 702–709, 1986

    PubMed  CAS  Google Scholar 

  • Gandara DR, Tanaka MT, Crowley J, Livingston RB. Comparison of standard dose cisplatin, high dose cisplatin and high dose cisplatin plus mitomycin in metastatic non small cell lung cancer: preliminary results of a phase III study. Abstract. Proceedings of the American Society of Clinical Oncology 10: 264, 1991

    Google Scholar 

  • Ganz PA, Figlin RA, Haskell CM, Lasoto N, for the UCLA Solid Tumour Study Group. Supportive care versus supportive care and combination chemotherapy in metastatic non small cell lung cancer: does chemotherapy make a difference?. Cancer 63: 1271–1278, 1989

    Article  PubMed  CAS  Google Scholar 

  • Gralla RJ, Kris MJ. In Williams & Whitehouse (Eds) Recent advances in clinical oncology. Management of non small cell lung cancer, pp. 167–180, Churchill Livingstone, London, 1986

    Google Scholar 

  • Gralla RJ, Casper ES, Kelsen DP, Kelsen DP, Braun DW, et al. Cisplatin and vindesine combination therapy for advanced carcinoma of the lung: randomised trial investigating two dosage schedules. Annals of Internal Medicine 95: 414–420, 1981

    PubMed  CAS  Google Scholar 

  • Holmes EC, Gail M. Surgical adjuvant therapy for Stage II and Stage III adenocarcinoma and large cell undifferentiated carcinoma. Journal of Clinical Oncology 4: 710–715, 1986

    PubMed  CAS  Google Scholar 

  • Ihde DC. Chemotherapy of lung cancer. New England Journal of Medicine 327: 1434–1441, 1992

    Article  PubMed  CAS  Google Scholar 

  • Ihde DC, Minna JD. Non small cell lung cancer, II, Treatment. Current Problems in Cancer 15: 105–154, 1991

    PubMed  CAS  Google Scholar 

  • Johnson DH. Chemotherapy for unresectable non small cell lung cancer. Seminars in Oncology 17 (Suppl. 7): 20–29, 1990

    PubMed  CAS  Google Scholar 

  • Kaasa S, Lund E, Thorud E, Hatlevoll R, Host H, et al. Symptomatic treatment versus combination chemotherapy for patients with extensive non small cell lung cancer. Cancer 67: 2443–2447, 1991

    Article  PubMed  CAS  Google Scholar 

  • Kelly P, O’Brien AAJ, Daly P, Clancy L. Small-cell lung cancer in elderly patients: the case for chemotherapy. Age and Ageing 20: 19–22, 1991

    Article  PubMed  CAS  Google Scholar 

  • Klastersky J, Sculier JP, Ravez P, Libert P, Michel J, et al. Randomised study comparing a high and a standard dose of cisplatin in combination with etoposide in the treatment of advanced non small cell lung carcinoma. Journal of Clinical Oncology 4: 1780–1786, 1986

    PubMed  CAS  Google Scholar 

  • Le Chevalier T, Arriagada R, Tarayre M, Lancombe-Terrier M-J, La Planche A, et al. Significant effect of adjuvant chemotherapy on survival on locally advanced non small cell lung carcinoma. Journal of the National Cancer Institute 84: 58–63, 1992

    Article  PubMed  Google Scholar 

  • Le Chevalier T, Arriagada R, Quoix E, Ruffie P, Martin M, et al. Radiotherapy alone versus combined chemotherapy and radiotherapy in non resectable non small cell lung cancer: first analysis of a randomised trial in 353 patients. Journal of the National Cancer Institute 83: 417–423, 1991

    Article  PubMed  Google Scholar 

  • Luedke DW, Einhorn L, Omura GA, Sarma PR, Bartolucci AA, et al. Randomised comparison of two combination regimens versus minimal chemotherapy in non small cell lung cancer: South Eastern Cancer Group trial. Journal of Clinical Oncology 8: 886–891, 1990

    PubMed  CAS  Google Scholar 

  • Lung Cancer Study Group. Effects of post operative mediastinal radiation on completely resected Stage II and Stage III epidermoid cancer of the lung. New England Journal of Medicine 315: 1377–1381, 1986

    Article  Google Scholar 

  • Lung Cancer Study Group. The benefit of adjuvant treatment for resected locally advanced non small cell lung cancer. Journal of Clinical Oncology 6: 9–17, 1988

    Google Scholar 

  • Martini K, Kris MG, Gralla RJ, Bains MS, McCormack P. The effects of pre-operative chemotherapy in the resectability of non small cell carcinoma with mediastinal lymph node metastases (N2 MO). Annals of Thoracic Surgery 45: 370–379, 1988

    Article  PubMed  CAS  Google Scholar 

  • Mattson K, Holsti LR, Holsti P, Jakobsson M, Kajanti M, et al. Inoperable non small cell lung cancer: radiation with or without chemotherapy. European Journal of Cancer and Clinical Oncology 24: 477–482, 1988

    Article  CAS  Google Scholar 

  • Miller TP. Rationale for the use of chemotherapy in non small cell lung cancer. Seminars in Oncology 17 (Suppl. 7): 11, 1990

    PubMed  CAS  Google Scholar 

  • Mountain CF. Therapy of Stage I and Stage II non small cell lung cancer. Seminars in Oncology 10: 71–80, 1983

    PubMed  CAS  Google Scholar 

  • O’Connell JP, Kris MG, Gralla RJ, Groshen S, Trust A, et al. Frequency and prognostic importance of pre-treatment characteristics in patients with advanced non small cell lung cancer treated with combination chemotherapy. Journal of Clinical Oncology 4: 1604–1614, 1986

    PubMed  Google Scholar 

  • O’Malley K, Meagher F, O’Callaghan W. The pharmacology of ageing. In Pathy MSJ (Ed.) Principles and practice of geriatric medicine, pp. 181–196, John Wiley and Sons Ltd, London, 1985

    Google Scholar 

  • Perez CA, Pajak TF, Rubin P, Simpson JR, Mohiuddin M. Long term observations of the patterns of failure in patients with unresectable non oat cell carcinoma of the lung treated with definitive radiotherapy: report by the Radiation Therapy Oncology Group. Cancer 59: 1874–1881, 1987

    Article  PubMed  CAS  Google Scholar 

  • Petrovich Z, Ohanian M, Cox J. Clinical research on the treatment of locally advanced lung cancer. Cancer 42: 1129–1134, 1978

    Article  PubMed  CAS  Google Scholar 

  • Rapp E, Pater JL, Willan A, Cormier Y, Murray N, et al. Chemotherapy can prolong survival in patients with advanced non small cell lung cancer: report of a Canadian multi-centre randomised trial. Journal of Clinical Oncology 6: 633–641, 1988

    PubMed  CAS  Google Scholar 

  • Rosell R, Abad-Estevea, Moreno I, Barnadas A, Carles J, et al. A randomised study of two vindesine plus cisplatin-containing regimens with the addition of mitomycin C and ifosfamide in patients with advanced non small cell lung cancer. Cancer 65: 1692–1699, 1990

    Article  PubMed  CAS  Google Scholar 

  • Rosso R, Salvati F, Ardizzoni A, Curcio CG, Rubagotti A, et al. Etoposide versus etoposide plus cisplatin in the management of advanced non small cell lung cancer: prospective randomised FONICAP trial. Cancer 65: 130–134, 1990

    Article  Google Scholar 

  • Ruckdeschel JC. Etoposide in the management of non small cell cancer. Cancer 67 (Suppl. 1): 250–253, 1991

    Article  PubMed  CAS  Google Scholar 

  • Ruckdeschel JC. Role of standard dose etoposide in th emanagement of non small cell lung cancer. Seminars in Oncology 19 (Suppl. 13): 39–44, 1992

    PubMed  CAS  Google Scholar 

  • Ruckdeschel JC, Finkelstein DM, Ettinger DS, Creech RH, Mason BA, et al. A randomised trial of the four most active regimens for metastatic non small cell lung cancer. Journal of Clinical Oncology 4: 14–22, 1986

    PubMed  CAS  Google Scholar 

  • Samet J, Hunt WC, Key C, Humble CG, Goodwin JS. Choice of cancer therapy varies with age of patient. Journal of the American Medical Association 255: 3385–3390, 1986

    Article  PubMed  CAS  Google Scholar 

  • Schaake-Koning C, Van den Bogaert W, Dalesio O, Festen J, Hoogenhout J, et al. Effects of concomitant cisplatin and radiotherapy on inoperable non small cell lung cancer. New England Journal of Medicine 326: 524–530, 1992

    Article  PubMed  CAS  Google Scholar 

  • Shields TW, Higgins GA, Humphrey EW, Matthews MJ, Keehn RJ. Prolonged intermittent adjuvant chemotherapy with CCNU and hydroxyurea after resection of carcinoma of the lung. Cancer 50: 1713–1721, 1982

    Article  PubMed  CAS  Google Scholar 

  • Shields TW, Humphrey EW, Eastridge CE, Keehn RJ. Adjuvant cancer chemotherapy after resection of carcinoma of the lung. Cancer 40: 2057–2062, 1977

    Article  PubMed  CAS  Google Scholar 

  • Skarin A, Jochelson M, Sheldon T, Malcolm A, Oliynyk P, et al. Neoadjuvant chemotherapy in marginally resectable Stage III MO non small cell lung cancer: long term follow up in 41 patients. Journal of Surgical Oncology 40: 266–274, 1989

    Article  PubMed  CAS  Google Scholar 

  • Sorensen JB, Hensen HH, Dombernowsky P, Bork E, Malmberg R, et al. Chemotherapy for adenocarcinoma of the lung: a randomised study of vindesine versus lomustine, cyclophosphamide and methotrexate versus all four drugs. Journal of Clinical Oncology 5: 1169–1177, 1987

    PubMed  CAS  Google Scholar 

  • Souquet PJ, Chauvin F, Boissel JP, Cellerino R, Cormier Y, et al. Polychemotherapy in advanced non small cell lung cancer: a meta-analysis. Lancet 342: 19–21, 1993

    Article  PubMed  CAS  Google Scholar 

  • Taylor SG, Trybula M, Bonomi PD, Faber LP, Lee MS, et al. Simultaneous cisplatin, 5 fluorouracil and radiation followed by surgical resection in regionally localised Stage III non small cell lung cancer. Annals of Thoracic Surgery 43: 87–91, 1987

    Article  PubMed  Google Scholar 

  • Veronesi A, Magri MD, Tirelli U, Carbone A, Mazza F, et al. Chemotherapy of advanced non small cell lung cancer with cyclophosphamide, adriamycin, methotrexate and procarbazine versus cisplatin and etoposide: a randomised study. American Journal of Clinical Oncology 11: 566–571, 1988

    Article  PubMed  CAS  Google Scholar 

  • Weiden PL, Piantadosi S. Pre-operative chemotherapy (cisplatin and fluorouracil) and radiation therapy in Stage III non small cell lung cancer: phase II study of the Lung Cancer Study Group. Journal of the National Cancer Institute 83: 266–273, 1991

    Article  PubMed  CAS  Google Scholar 

  • Wetle T. Age as a risk factor for inadequate treatment. Journal of the American Medical Association 258: 516, 1987

    Article  PubMed  CAS  Google Scholar 

  • Wong JB, Salem DM, Parker SG. Occasional notes: you are never too old. New England Journal of Medicine 328: 971–975, 1993

    Article  PubMed  CAS  Google Scholar 

  • Zagonel V, Tirelli U, Serraino D, Lo Re G, Merola MC, et al. The Aged Patient with Lung Cnacer: Management Recommendations. Drugs & Aging 4(1): 34–46, 1994

    Article  CAS  Google Scholar 

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  1. Peamont Hospital, Newcastle, County Dublin, Ireland

    Paul Kelly & Luke Clancy

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  1. Paul Kelly
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Kelly, P., Clancy, L. Is the Use of Chemotherapy Justified in Non-Small-Cell Lung Cancer?. Drugs & Aging 4, 1–8 (1994). https://doi.org/10.2165/00002512-199404010-00001

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