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Multicentre Study of l-α-Glyceryl-Phosphorylcholine vs ST200 among Patients with Probable Senile Dementia of Alzheimer’s Type

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Summary

A multicentre, randomised, controlled study compared the efficacy of l-α-glyceryl-phosphorylcholine (αGPC) and ST200 (acetyl-l-carnitine) among 126 patients with probable senile dementia of Alzheimer’s type (SDAT) of mild to moderate degree. Efficacy was evaluated by means of behavioural scales and psychometric tests. The results showed significant improvements in most neuropsychological parameters in the αGPC recipients. Improvements also occurred in the ST200 recipients but to a lesser extent. Tolerability was good in both groups. These positive findings require replication in larger, double-blind, longitudinal studies coupling clinical and biological determinations.

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Authors and Affiliations

  1. Institute of Gerontology and Geriatrics, University of Perugia, Via Eugubina 42, 06100, Perugia, Italy

    L. Parnetti & U. Senin

  2. University of Chieti, Chieti, Italy

    G. Abate (Chair of Gerontology)

  3. Geriatric Department, The City Hospital, Sezze Romano, Italy

    L. Bartorelli

  4. Geriatric Department, Malpighi Hospital, Bologna, Italy

    D. Cucinotta

  5. Geriatric Department, The City Hospital, Fano, Italy

    M. Cuzzupoli

  6. Neurology Department, Zucchi Clinic, Carate Brianza, Italy

    M. Maggioni

  7. University of Catania, Italy

    C. Villardita (Second Chair of Neurological Pathology)

Authors
  1. L. Parnetti
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  2. G. Abate
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  3. L. Bartorelli
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  4. D. Cucinotta
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  5. M. Cuzzupoli
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  6. M. Maggioni
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  7. C. Villardita
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  8. U. Senin
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Parnetti, L., Abate, G., Bartorelli, L. et al. Multicentre Study of l-α-Glyceryl-Phosphorylcholine vs ST200 among Patients with Probable Senile Dementia of Alzheimer’s Type. Drugs & Aging 3, 159–164 (1993). https://doi.org/10.2165/00002512-199303020-00006

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  • DOI: https://doi.org/10.2165/00002512-199303020-00006

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