Summary
A population study of drug consumption among people born in 1902 was performed in Umeå, Sweden. The cohort was followed between 79 and 88 years of age. The number of persons in the study varied between 124 and 72. Mean consumption increased from 2.5 to 5.2 drugs per man and from 3.3 to 5.3 per woman. The main correlate of this increase was shown to be the aging individuals’ greater morbidity. Cardiovascular preparations, analgesics, psychoactive substances and drugs used to alleviate gastrointestinal symptoms were the most common. At the age of 88 years, 45 to 55% of the individuals used drugs belonging to each one of these drug groups. Furthermore, during the 9 years of study there was a substantial increase in use of these drug groups except for the cardiovascular agents, of which the consumption was constant. The proportion of subjects on regular drugs increased from 82% at 79 years to 95% at 88 years of age. Benzodiazepines were, at 88 years, used by almost 40% of the population; at the same age, 43% were using laxatives and 37% diuretics. Paracetamol (acetaminophen) was the most common analgesic used. Total consumption of drugs prescribed for hypertension decreased considerably, from 23 to 10%, despite an increase in the use of loop diuretics and vasodilating agents.
Similar content being viewed by others
References
Amery A, Birkenhäger W, Brixko P, Bulpitt C, Clement D, et al. Mortality and morbidity results from the European Working Party on high blood pressure in the elderly trial. Lancet 1: 1349–1354, 1985
Amery A, Hansson L, Andrén L, Gudbrandsson T, Sivestsson R, et al. Hypertension in the elderly. Acta Medica Scandinavie 210: 221–229, 1981
Bergman U, Wiholm B-E. Patient medication on admission to a medical clinic. European Journal of Clinical Pharmacology 20: 185–191, 1981
Boethius G. Recording of drug prescriptions in the county of Jämtland, Sweden. Acta Medica Scandinavica 202: 241–251, 1977
Burns E, Austin CA, Bax NDS. Elderly patients’ understanding of their drug therapy: the effect of cognitive function. Age and Ageing 19: 236–240, 1990
Chen LH, Liu S, Cook Newell ME, Barnes K. Survey of drug use by the elderly and possible impact of drugs on nutritional status. Drug-Nutrient Interactions 3: 73–86, 1985
Fry J. Natural history of hypertension: a case for selective non-treatment. Lancet 2: 431–433, 1974
Gardner P, Cluff LE. The epidemiology of adverse drug reactions. A review and perspective. Johns Hopkins Medical Journal 126: 77–87, 1970
Greenblatt DJ, Sellers EM, Shader RI. Drug disposition in old age. New England Journal of Medicine 306: 1081–1088, 1982
Guttman D. Patterns of legal drug use by older Americans. Addictive Diseases 3: 337–356, 1978
Hale WE, Perkins LL, May FE, Marks RG, Stewart RB. Symptom prevalence in the elderly. An evaluation of age, sex, disease and medication use. Journal of the American Geriatrics Society 34: 333–340, 1986
Helling DK, Lemke JH, Semla TP, Wallace RB, Lipson DP, et al. Medication use characteristics in the elderly: the Iowa 65 + rural health study. Journal of the American Geriatrics Society 35: 4–12, 1987
Hendriksen C, Lund E, Strømgård E. Intake of drugs among elderly people in a Danish municipality, Rødovre. Acta Medica Scandinavica 214: 67–71, 1983
Holme I, Waaler HT. Five-year mortality in the city of Bergen, Norway, according to age, sex and blood pressure. Acta Medica Scandinavica 200: 229–239, 1976
Holstein BE, Almind G, Due P, Holst E. Aeldres selvrapporterede helbred og laegemiddelforbrug. Ugeskrift for laeger 152: 386–391, 1990
Hulka BS, Kupper LL, Cassel JC, Efird RL. Medication use and misuse: physiciain-patient discrepancies. Journal of Chronic Diseases 28: 7–21, 1975
Hurwitz N. Predisposing factors in adverse reactions to drugs. British Medical Journal 1: 536–539, 1969
Knapp DA, Knapp DA, Wiser TH, Michocki RJ, Nuessle SJ, et al. Drug prescribing for ambulatory patients 85 years of age and older. Journal of the American Geriatrics Society 32: 138–143, 1984
Lamy PP. Over-the-counter medications: The drug interactions we overlook. Journal of the American Geriatrics Society 30: 69–75, 1982
Landahl S. Drug treatment in 70–82-year-old persons. Acta Medica Scandinavica 221: 179–184, 1987
Law R. Chalmers C. Medicines and elderly people: a general practice survey. British Medical Journal 1: 565–568, 1976
May FE, Stewart RB, Hale WE, Marks RG. Prescribed and non-prescribed drug use in an ambulatory elderly population. Southern Medical Journal 75: 522–528, 1982
Montamat SC, Cusack BJ, Vestal RE. Management of drug therapy in the elderly. New England Journal of Medicine 321: 303–309, 1989
Nolan L, O’Malley K. Prescribing for the elderly. Part I: Sensitivity of the elderly to adverse drug reactions. Journal of the American Geriatrics Society 36: 142–149, 1988
Nordic Council on Medicines. Nordic Statistics on Medicines 1981–1983. Guidelines for ATC classification. NLN Publication No. 14, Uppsala, 1986
Österlind P-O, Löfgren A-C, Sandman P-O, Steen B, Winblad B. Health, disorders and drug consumption in an elderly population in northern Sweden. Gerontology 32: 52–59, 1986
Ouslander JG. Drug therapy in the elderly. Annals of Internal Medicine 95: 711–722, 1981
Rozzini R, Bianchetti A, Zanetti O, Trabucchi M. Are too many drugs prescribed for the elderly after all? Journal of the American Geriatrics Society 37: 89–90, 1989
Schmucker DL. Drug disposition in the elderly: a review of the critical factors. Journal of the American Geriatrics Society 32: 144–149, 1984
Shapiro S, Avery KT, Carpenter RD. Drug utilization by a non-institutionalized ambulatory elderly population. Gerodontics 2: 99–103, 1986
Skegg DCG, Doll R, Perry J. Use of medicines in general practice. British Medical Journal 1: 1561–1563, 1977
Spagnoli A, Ostino G, Borga AD, DÁmbrosio R, Maggiorotti P, et al. Drug compliance and unreported drugs in the elderly. Jounrnal of the American Geriatrics Society 37: 619–624, 1989
Stewart RB. Noncompliance in the elderly: is there a cure? Drugs and Aging 1: 163–167, 1991
Stewart RB, Cluff LE. Studies on the epidemiology of adverse drug reactions VI: utilization and interactions of prescription and nonprescription drugs in outpatients. Johns Hopkins Medical Journal 129: 319–331, 1971
Stoller EP. Prescribed and over-the-counter medicine use by the ambulatory elderly. Medical Care 26: 1149–1157, 1988
Verbrugge LM. Gender and health: an update on hypotheses and evidence. Journal of Health and Social Behavior 26: 156–182, 1985
Verbrugge LM, Steiner RP. Prescribing drugs to men and women. Health Psychology 4: 79–98, 1985
Vestal RE. Drug use in the elderly: a review of problems and special considerations. Drugs 16: 358–382, 1978
Vestal RE. Pharmacology and aging. Journal of the American Geriatrics Society 30: 191–200, 1982
Weedle PB, Poston JW, Parish PA. Drug prescribing in residential homes for elderly people in the United Kingdom. DICP: Annals of Pharmacotherapy 24: 533–536, 1990
Wilkinson L. SYSTAT: the system for statistics. SYSTAT, Inc., Evanston, Illinois, 1989
Williamson J. Prescribing problems in the elderly. Practitioner 220: 749–755, 1978
Williamson J, Chopin JM. Adverse reactions to prescribed drugs in the elderly: a multicentre investigation. Age and Aging 9: 73–80, 1980
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Österlind, PO., Bucht, G. Drug Consumption During the Last Decade Among Persons Born in 1902 in Umeå Sweden. Drugs & Aging 1, 477–486 (1991). https://doi.org/10.2165/00002512-199101060-00007
Published:
Issue Date:
DOI: https://doi.org/10.2165/00002512-199101060-00007