Skip to main content
SpringerLink
Log in

Transdermal Nitroglycerin

Does it Really Work in the Treatment of Angina?

  • Leading Article
  • Published:
Drugs & Aging Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Abrams J. The brief saga of transdermal nitroglycerin. discs: Paradise Lost? American Journal of Cardiology 54: 220–224, 1984

    Article  PubMed  CAS  Google Scholar 

  • Abrams J. Transdermal nitroglycerin and nitrate tolerance. Annals of Internal Medicine 104: 424–426, 1986

    PubMed  CAS  Google Scholar 

  • Abrams J. A reappraisal of nitrate therapy. Clinical Cardiology 259: 396–401, 1988

    CAS  Google Scholar 

  • Bridgman KM, Carr M, Tattersall AB. Post-marketing surveillance of the transderm-nitro patch in general practice. Journal of International Medical Research 12: 40–45, 1984

    PubMed  CAS  Google Scholar 

  • Colditz GA, Halvorsen KT, Goldhaber SZ. Randomized clinical trials of transdermal nitroglycerin systems for the treatment of angina: a meta-analysis. American Heart Journal 116: 174–180, 1988

    Article  PubMed  CAS  Google Scholar 

  • Connor CS, Gelman CJR. Transdermal nitroglycerin: a reevaluation. Drug Intelligence and Clinical Pharmacy 18: 889–890, 1984

    Google Scholar 

  • Cowan JC, Bourke JP, Reids DS, et al. Prevention of tolerance to nitroglycerin patches by overnight removal. American Journal of Cardiology 60: 271–275, 1987

    Article  PubMed  CAS  Google Scholar 

  • Crean PA, Ribeiro P, Crea F, et al. Failure of transdermal nitroglycerin to improve chronic stable angina: a randomized, placebo-controlled, double-blind, crossover trial. American Heart Journal 6: 1494–1500, 1984

    Article  Google Scholar 

  • Curry SH. Transdermal nitroglycerin patches. Clinical Pharmacy 4: 453–454, 1985

    PubMed  CAS  Google Scholar 

  • Dahlstrom CG, Rasmussen K, Bagger JP, et al. Transdermal nitroglycerin (Transiderm-Nitro) in the treatment of unstable angina pectoris. Danish Medical Bulletin 33: 265–267, 1986

    PubMed  CAS  Google Scholar 

  • Demots H, Glasser SP. Intermittent transdermal nitroglycerin therapy in the treatment of chronic stable angina. Journal of the American College of Cardiology 13: 789–793, 1989

    Article  Google Scholar 

  • Desilvio A, Barlattani MP. How best to use nitrates. British Medical Journal 295: 1163–1164, 1987

    Article  PubMed  CAS  Google Scholar 

  • Dickstein K, Knutsen H. A double-blind multiple crossover trial evaluating a transdermal nitroglycerin system vs placebo. European Heart Journal 6: 50–56, 1985

    PubMed  CAS  Google Scholar 

  • Dogar H, Güzelsoy D, Gultekin N, Gurses N, Demiroglo C. Active and sustained antianginal effects of nitroglycerin patches: objective evaluation with training effect eliminated exercise performance index. American Journal of Cardiology 61: 39E–43E, 1988

    Article  PubMed  CAS  Google Scholar 

  • Ferratini M, Pirelli S, Merlini P, Silva P, Pollavini G. Intermittent transdermal nitroglycerin monotherapy in stable exercise induced angina: a comparison with a continuous schedule. European Heart Journal 10: 998–1002, 1989

    PubMed  CAS  Google Scholar 

  • Fletcher A, McLoone P, Bulpitt C. Quality of life on angina therapy: a randomised controlled trial of transdermal glyceryl trinitrate against placebo. Lancet 2: 4–7, 1988

    Article  PubMed  CAS  Google Scholar 

  • Garnier H, Johnson LC. Treatment of patients with angina pectoris in general practice with a new transdermal therapeutic system containing nitroglycerin (Nitroderm TTS). Schweiz Rundsch Med Prax 71: 511–516, 1982

    PubMed  CAS  Google Scholar 

  • Georgopoulos AJ, Markis A, Georgiadis H. Therapeutic efficacy of a new transdermal system containing nitroglycerin in patients with angina pectoris. European Journal of Clinical Pharmacology 22: 481–485, 1982

    Article  PubMed  CAS  Google Scholar 

  • Greco R, D’Alterio D, Schiatterella M, Boccia A, Greco L, et al. Efficacy of a new transdermal nitroglycerin patch (Deponit 10) for stable angina pectoris. American Journal of Cardiology 61: 41E–51E, 1988

    Article  Google Scholar 

  • Heepe W. An acute double-blind placebo-controlled study of transdermal glyceryl trinitrate with 12 months’ follow up in patients with stable angina pectoris. Journal of International Medical Research 15: 198–204, 1987

    PubMed  CAS  Google Scholar 

  • James MA, Walker PR, Papouchado M, Wilkinson PR. Efficacy of transdermal glyceryl trinitrate in the treatment of chronic stable angina pectoris. British Heart Journal 53: 631–635, 1985

    Article  PubMed  CAS  Google Scholar 

  • Kapoor AS, Narinder SD, Reynolds RD. Sustained effects of transdermal nitroglycerin in patients with angina pectoris. Clinical Therapeutics 7: 674–679, 1985

    PubMed  CAS  Google Scholar 

  • Letzel.H, Johnson LC. Advances in nitrate therapy for ischaemic heart disease: results of a multicentre study with Transiderm Nitro. Zeitschrift für Allgemeinmedizin 59: 1022–1027, 1983

    PubMed  CAS  Google Scholar 

  • Letzel H, Johnson LC. Treatment of angina pectoris with Nitroderm TTS: results of a multicentre field study in 37, 596 patients. Medizinische Welt 35: 326–332, 1984

    Google Scholar 

  • Luke R, Sharpe N, Coxon R. Transdermal nitroglycerin in angina pectoris: efficacy of intermittent application. Journal of the American College of Cardiology 10: 642–646, 1987

    Article  PubMed  CAS  Google Scholar 

  • Midtbo K. A comparative study of transdermal nitroglycerin versus placebo in the treatment of stable angina pectoris. In Bussmann W & Zanchetti A (Eds) Transdermal nitroglycerin therapy, pp. 35–41, Hans Huber, 1985

  • Mufson LH, Wenger NK. Transdermal nitroglycerin discs: are they effective therapy? Quality of Life and Cardiovascular Care 2: 319–322, 1986

    Google Scholar 

  • Muiesan G, Agabiti-Rossei E, Muiesan L, et al. A multicenter trial of transdermal nitroglycerin in exercise-induced angina: individual antianginal response after repeated administration. American Heart Journal 112: 233–238, 1986

    Article  PubMed  CAS  Google Scholar 

  • Nabel EG, Barry J, Rocco MB, et al. Effects of dosing intervals on the development of tolerance to high dose transdermal nitroglycerin. American Journal of Cardiology 63: 663–669, 1989

    Article  PubMed  CAS  Google Scholar 

  • Parker JO. Transdermal isosorbide dinitrate in angina pectoris: effect of acute and sustained therapy. American Journal of Cardiology 54: 8–13, 1984

    Article  PubMed  CAS  Google Scholar 

  • Parker JO. Efficacy of nitroglycerin patches: fact or fancy. Annals of Internal Medicine 102: 548–550, 1985

    PubMed  CAS  Google Scholar 

  • Parker JO. Nitrate therapy in stable angina pectoris. New England Journal of Medicine 316: 1635–1640, 1987

    Article  PubMed  CAS  Google Scholar 

  • Parker JO. Intermittent transdermal nitroglycerin therapy in the treatment of chronic stable angina. Journal of the American College of Cardiology 13: 794–795, 1989

    Article  PubMed  CAS  Google Scholar 

  • Parker JO, Fung HL. Transdermal nitroglycerin in angina pectoris. American Journal of Cardiology 54: 471–476, 1984

    Article  PubMed  CAS  Google Scholar 

  • Pirelli CS, Ferratini M, Gasparini G, et al. The effects on exercise tolerance of a new transdermal therapeutic system containing nitroglycerine, in patients with stable angina pectoris. European Heart Journal 9: 105–111, 1988

    PubMed  Google Scholar 

  • Reichek N, Priest C, Zimrin D, et al. Antianginal effects of nitroglycerin patches. American Journal of Cardiology 54: 1–7, 1984

    Article  PubMed  CAS  Google Scholar 

  • Rezakovic DE. Relation of transdermal nitroglycerin efficacy with dosage in different subsets of patients. American Journal of Cardiology 61: 59E–69E, 1988

    Article  PubMed  CAS  Google Scholar 

  • Rezakovic DE, Pavicic L, Majacic M. A randomised placebo controlled, double-blind crossover trial of transdermal nitroglycerin in stable angina pectoris. European Heart Journal 9: 73–81, 1988

    PubMed  Google Scholar 

  • Scardi S, Pandullo C, Pivotti F, et al. Individual responses to transdermal nitrates after chronic administration in angina pectoris. International Journal of Cardiology 21: 21–32, 1988

    Article  PubMed  CAS  Google Scholar 

  • Scardi S, Pivotti F, Fonda F, et al. Effect of a new transdermal therapeutic system containing nitroglycerin on exercise capacity in patients with angina pectoris. American Heart Journal 110: 546–551, 1985

    Article  PubMed  CAS  Google Scholar 

  • Schaer DH, Buff LA, Katz RJ. Sustained antianginal efficacy of transdermal nitroglycerin patches using an overnight 10 hour nitrate-free interval. American Journal of Cardiology 61: 46–50, 1988

    Article  PubMed  CAS  Google Scholar 

  • Scheidt S. Update on transdermal nitroglycerin: an overview. American Journal of Cardiology 56: 50–71, 1985

    Article  Google Scholar 

  • Sullivan M, Savvides M, Abouantoun S, et al. Failure of transdermal nitroglycerin to improve exercise capacity in patients with angina pectoris. Journal of the American College of Cardiology 5: 1220–1223, 1985

    Article  PubMed  CAS  Google Scholar 

  • Terland O, Eidsaunet W. A double-blind multicenter crossover general practice study of glyceryl trinitrate delivered by a transdermal therapeutic system in stable angina pectoris. Current Therapeutic Research 39: 214–222, 1986

    Google Scholar 

  • Thadani U, Hamilton SF, Olson E. Transdermal nitroglycerin patches in angina pectoris. Annals of Internal Medicine 105: 485–492, 1986

    PubMed  CAS  Google Scholar 

  • Thompson R. Influence of transdermal nitrates on exercise capacity in patients with stable angina. Angiology 37(6): 448–453, 1986

    Article  PubMed  CAS  Google Scholar 

  • Waters DD, Juneau M, Gossard D, Choquette G, Brien M. Limited usefulness of intermittent nitroglycerin patches in stable angina. Journal of the American College of Cardiology 13: 421–425, 1989

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Epidemiology Research Unit, Division of Geriatric Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London, W12 ONN, England

    Astrid Fletcher

Authors
  1. Astrid Fletcher
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fletcher, A. Transdermal Nitroglycerin. Drugs & Aging 1, 6–16 (1991). https://doi.org/10.2165/00002512-199101010-00003

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00002512-199101010-00003

Keywords

Search

Navigation