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Anaphylactoid and Anaphylactic Reactions

Hazards of β-Blockers

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Summary

Studies have demonstrated greater hazards associated with anaphylaxis in patients receiving β-blockers. Serious anaphylaxis is more frequent. Evidence suggests this occurs via modulation of adenylate cyclase, which can influence release of anaphylactogenic mediators. Treatment of anaphylaxis in patients exposed to β-blockers is complicated because therapeutic administration of epinephrine (adrenaline) may be ineffective or promote undesired α-adrenergic and vagotonic effects. Risk reduction efforts should be considered for patients receiving β-blockers who are prone to experience anaphylaxis.

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Authors and Affiliations

  1. Department of Medicine, Division of Allergy and Immunology, Hahnemann University, Mail Stop 107, Broad and Vine Streets, Philadelphia, Philadelphia, 19102-1192, USA

    David M. Lang

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Lang, D.M. Anaphylactoid and Anaphylactic Reactions. Drug-Safety 12, 299–304 (1995). https://doi.org/10.2165/00002018-199512050-00002

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