Skip to main content
SpringerLink
Log in

The Risks and Benefits of Withdrawing Antiepileptic Therapy

  • Leading Article
  • Published:
Drug Safety Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Arts WFM, Visser LH, Loonen MCB, Tjiam AT, Stroink H, et al. Follow-up of 146 children with epilepsy after withdrawal of antiepileptic therapy. Epilepsia 29: 244–250, 1988

    Article  PubMed  CAS  Google Scholar 

  • Bouma PAD, Peters ACB, Arts RJM, Stijnen TH, Rossum JV. Discontinuation of antiepileptic therapy: a prospective study in children. Journal of Neurology, Neurosurgery and Psychiatry 50: 1579–1583, 1987

    Article  CAS  Google Scholar 

  • Callaghan N, Garrett A, Goggin T. Withdrawal of anticonvulsant drugs in patients free of seizures for two years: a prospective study. New England Journal of Medicine 318: 942–946, 1988a

    Article  PubMed  CAS  Google Scholar 

  • Callaghan N, Goggin T, Garrett A. Correspondence. New England Journal of Medicine 319: 872, 1988b

    Article  Google Scholar 

  • Davies-Jones GA. Complications of anticonvulsant therapy. In Dukes (Ed.) Meylers’s side effects of drugs, pp. 120–136, Elsevier Science Publishers, New York, 1988

    Google Scholar 

  • Emerson R, Ds’Souza BJ, Vining EP, Holden KR, Mellits ED, et al. Stopping medication in children with epilepsy: predictors of outcome. New England Journal of Medicine 304: 1125–1129, 1981

    Article  PubMed  CAS  Google Scholar 

  • Engel J. General principles of treatment. In Seizures and epilepsy, p. 398, F.A. Davis Company, Philadelphia, 1989

    Google Scholar 

  • Holwach J, Thurston DL, Os’Leary J. Prognosis in childhood epilepsy: follow-up study of 148 cases in which therapy had been suspended after prolonged anticonvulsant control. New England Journal of Medicine 286: 169–174, 1972

    Article  Google Scholar 

  • Matricardi M, Brinciotti M, Benedetti P. Outcome after discontinuation of antiepileptic drug therapy in children with epilepsy. Epilepsia 30: 582–589, 1989

    Article  PubMed  CAS  Google Scholar 

  • Medical Research Council Antiepileptic Drug Withdrawal Study Group. Randomized study of antiepileptic drug withdrawal in patients in remission. Lancet 337: 1175–1180, 1991

    Google Scholar 

  • Reynolds EH. Chronic antiepileptic toxicity: a review. Epilepsia 16: 319–352, 1975

    Article  PubMed  CAS  Google Scholar 

  • Reynolds EH. Mental effects of antiepileptic medications: a review. Epilepsia 24(Suppl. 2): S85–S95, 1983

    Article  PubMed  Google Scholar 

  • Rosen JA. To the editor: discontinuing antiepileptic drugs. New England Journal of Medicine 319: 871–872, 1988

    Google Scholar 

  • Schmidt D. Toxicity of antiepileptic drugs. In Pedley & Meldrum (Eds) Recent advances in epilepsy. Vol. 3, pp. 221–232, Churchill Livingstone, New York, 1986

    Google Scholar 

  • Shafer SQ, Hauser WA, Annegers JF, Klass DW. EEG and other early predictors of epilepsy remission: a community study. Epilepsia 29: 590–600, 1988

    Article  PubMed  CAS  Google Scholar 

  • Shinnar S, Vining EPG, Mellits ED, Ds’Souza BJ, Holden K, et al. Discontinuing antiepileptic medication in children with epilepsy after two years without seizures: a prospective study. New England Journal of Medicine 313: 976–980, 1985

    Article  PubMed  CAS  Google Scholar 

  • Thurston JH, Thurston DL, Hixon BB, Keller AJ. Prognosis in childhood epilepsy: additional follow-up of 148 children 15–23 years after withdrawal of anticonvulsant therapy. New England Journal of Medicine 306: 831–836, 1982

    Article  PubMed  CAS  Google Scholar 

  • Todt H. The late prognosis of epilepsy childhood: results of a prospective follow-up study. Epilepsia 25: 137–144, 1984

    Article  PubMed  CAS  Google Scholar 

  • Tugwell P. How to read clinical journals: III. To learn the clinical course and prognosis of disease. Canadian Medical Association Journal 124: 869–872, 1981

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland, 20814, USA

    Barbara Scherokman & Bahman Jabbari

  2. The Neurology Service, Walter Reed Army Medical Center, Washington, DC, USA

    Barbara Scherokman & Bahman Jabbari

Authors
  1. Barbara Scherokman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bahman Jabbari
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The opinions or assertions contained herein are the private ones of the authors) and are not to be construed as representing the views of the Department of Defense, the Department of the Army or the Uniformed Services University of the Health Sciences.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Scherokman, B., Jabbari, B. The Risks and Benefits of Withdrawing Antiepileptic Therapy. Drug-Safety 8, 399–403 (1993). https://doi.org/10.2165/00002018-199308060-00001

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00002018-199308060-00001

Keywords

Search

Navigation