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A Case of Destructive Polyarthropathy in a 17-Year-Old Youth Following Pefloxacin Treatment

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Summary

Joint and muscle pain have been reported with quinolones; however, arthropathies induced by quinolones do not result in erosive changes in humans, although such changes have occurred in animal studies.

We report an unusual case of destructive polyarthropathy in a 17-year-old boy after treatment with pefloxacin 800 mg/day for 3 months. Pefloxacin may have accentuated the cartilage damage in this case, even if an underlying joint disease could not be excluded.

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References

  • Bailey RR, Natale R, Linton AL. Nalidixic acid arthralgia. Canadian Medical Association Journal 107: 604, 1972

    PubMed  Google Scholar 

  • Boerema JBJ, Pauwels R, Scheeper SJ, Grombach W. Efficacy and safety of pefloxacin in the treatment of patients with complicated urinary tract infections. Antimicrobial Agents and Chemotherapy 17(B): 103–109, 1986

    Google Scholar 

  • Cassidy JT. Juvenile rheumatoid arthritis. In Kelley et al. (Eds) Textbook of Rheumatology, pp. 1289–1311, 3rd edition, Saunders Company, Philadelphia, 1989

    Google Scholar 

  • Chevais M, Reinert P, Rondeau MC, Tobelem R, Albengres E, et al. Critical risk/benefit analysis of pefloxacin use in children under 15 years: the problem of arthralgias. International Journal of Clinical Pharmacology Therapy and Toxicology 25: 306–309, 1987

    CAS  Google Scholar 

  • Dellamonica P, Bernard E, Etesse M, Garaffo R. The diffusion of pefloxacin into bone and the treatment of osteomyelitis. Antimicrobial Agents and Chemotherapy 17(B): 93–102, 1986

    Google Scholar 

  • Fast A, Alon M, Weiss S, Zer-Aviv F. Avascular necrosis of bone following short-term dexamethasone therapy for brain oedema. Journal of Neurosurgery 61: 983, 1984

    Article  PubMed  CAS  Google Scholar 

  • Hooper DC, Wolfson JS. The fluoroquinolones: pharmacology, clinical uses and toxicities in humans. Antimicrobial Agents and Chemotherapy 28: 716–721, 1985

    Article  PubMed  CAS  Google Scholar 

  • Jorgensen C, Anaya JM, Didry C, Canovas F, Serre I, et al. Arthropathies et tendinopathies achilléennes induites par la péfloxacine. A propos d’une observation. Revue du Rhumatisme et des Maladies Osteo-Articulaires 58: 623–625, 1991

    PubMed  CAS  Google Scholar 

  • Kato M, Onodeia T. Morphological investigation of osteochondritis induced by ofloxacin in rats. Fundamental and Applied Toxicology 11: 120–131, 1988

    Article  PubMed  CAS  Google Scholar 

  • Kesseler A, Lacassie A, Hugot JP, Talon Ph, Thomas D, et al. Arthropathies consécutives à l’adminiostration de pefloxacinechez un adolescent atteint de mucoviscidose. Annales de Pediatrie 36: 275–278, 1989

    PubMed  CAS  Google Scholar 

  • Mc Evans JR, Davey PG. Ciprofloxacin and tenosynovitis. Lancet 2: 900, 1988

    Google Scholar 

  • Maroteaux P. Epiphyseal dysplasia multiple. In Bergsma D. (Ed.) Birth defects compendium, p. 409, National Foundation, March of Dimes, Alan R. Liss Inc., New York, 1979

    Google Scholar 

  • Schulter G. Ciprofloxacin: review of potential toxicological effects. American Journal of Medicine 82(Suppl. 4A): 91–93, 1987

    Google Scholar 

  • Sthalmann R, Merker HJ, Hinz N, Chahoud I, Webb J, et al. Ofloxacin in juvenile non-human primates and rats: arthropathia and drug plasma concentrations. Archives of Toxicology 64: 193–204, 1980

    Article  Google Scholar 

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Authors and Affiliations

  1. Departments of Rheumatology, Pathology and Pharmacology, and French System for Postmarketing Drug Surveillance, Hôpital Henri-Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France

    Xavier Chevalier, Edith Albengres, Marie-Catherine Voisin, Jean-Paul Tillement & Bruno Larget-Piet

  2. Department of Pharmacology, Hôpital Intercommunal, Créteil, France

    Xavier Chevalier, Edith Albengres, Marie-Catherine Voisin, Jean-Paul Tillement & Bruno Larget-Piet

Authors
  1. Xavier Chevalier
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  2. Edith Albengres
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  3. Marie-Catherine Voisin
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  4. Jean-Paul Tillement
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  5. Bruno Larget-Piet
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Chevalier, X., Albengres, E., Voisin, MC. et al. A Case of Destructive Polyarthropathy in a 17-Year-Old Youth Following Pefloxacin Treatment. Drug-Safety 7, 310–314 (1992). https://doi.org/10.2165/00002018-199207040-00007

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  • DOI: https://doi.org/10.2165/00002018-199207040-00007

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