, Volume 30, Issue 8, pp 647–660 | Cite as

Economic Evaluations of Childhood Influenza Vaccination

A Critical Review
  • Anthony T. NewallEmail author
  • Mark Jit
  • Philippe Beutels
Review Article


The potential benefits of influenza vaccination programmes targeted at children have gained increasing attention in recent years.

We conducted a literature search of economic evaluations of influenza vaccination in those aged ≤18 years. The search revealed 20 relevant articles, which were reviewed. The studies differed widely in terms of the costs and benefits that were included. The conclusions were generally favourable for vaccination, but often applied a wider perspective (i.e. including productivity losses) than the reference case for economic evaluations used in many countries. Several evaluations estimated outcomes from a single-year epidemiological study, which may limit their validity given the year-to-year variation in influenza transmissibility, virulence, vaccine match and prior immunity. Only one study used a dynamic transmission model able to fully incorporate the indirect herd protection to the wider community.

The use of dynamic models offers great scope to capture the population-wide implications of seasonal vaccination efforts, particularly those targeted at children.


Influenza Economic Evaluation Influenza Vaccine Influenza Vaccination Health Technology Assessment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



ATN holds a National Health and Medical Research Council (NHMRC) Training Fellowship (no. 630724; Australian-based Public Health Fellowship). PB is supported by ‘SIMID’ (Simulation Models of Infectious Disease Transmission and Control Processes), a project funded by the Flemish Government Agency for Innovation by Science and Technology (IWT).

ATN has in the past received research funding for other previous projects from a manufacturer of the influenza vaccine, GlaxoSmithKline Pty Ltd. MJ and PB have no conflicts to declare.

ATN led the project and conducted the literature review. PB initiated the idea for the review. ATN and MJ assembled the tables in consultation with PB. All authors contributed to the study design, the analysis and interpretation of the literature, and the drafting of the manuscript. ATN acts as the guarantor for the content of this paper.

This paper is part of a theme issue co-edited by Lisa Prosser, University of Michigan, USA, and no external funding was used to support the publication of this theme issue.


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Copyright information

© Springer International Publishing AG 2012

Authors and Affiliations

  • Anthony T. Newall
    • 1
    Email author
  • Mark Jit
    • 2
  • Philippe Beutels
    • 1
    • 3
  1. 1.School of Public Health and Community MedicineUniversity of New South WalesSydneyAustralia
  2. 2.Modelling and Economics UnitHealth Protection AgencyLondonUK
  3. 3.Centre for Health Economics Research and Modelling Infectious Diseases (CHERMID), Vaccine and Infectious Disease InstituteUniversity of AntwerpAntwerpBelgium

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