Clinical Drug Investigation

, Volume 31, Supplement 1, pp 19–24

Bupropion in the Treatment of Major Depressive Disorder in Real-life Practice

  • Diogo Azevedo Oliveira Sennfelt
  • Maria Alice Rodrigues Marques da Silva
  • Anabela Pereira da Silva Tavares
Clinical Management


Major depressive disorder (MDD) is one of the most common mental disorders, with a lifetime prevalence of approximately 13% in Europe. Although the primary symptom of MDD is depressed mood and a loss of interest or pleasure in everyday life, patients with MDD often present with a variety of other symptoms, such as sleep disturbances, fatigue, anxiety and somatic complaints. Antidepressant drugs are frequently used as first-line therapy for MDD. Bupropion is a second-generation antidepressant drug that inhibits reuptake of the neurotransmitters dopamine and norepinephrine, and has no direct serotonergic effects, a unique property among antidepressants. This article highlights the use of bupropion in the treatment of three patients with varying presentations of MDD, including as combination therapy in a patient refractory to treatment with a selective serotonin reuptake inhibitor, monotherapy in a patient with somatic symptoms of depression and loss of libido, and in a patient complaining of anxiety as a symptom of MDD. Bupropion treatment was successful in all patients, resulting in remission of symptoms and the patients returning to their normal lives.


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Copyright information

© Adis Data Information BV 2011

Authors and Affiliations

  • Diogo Azevedo Oliveira Sennfelt
    • 1
  • Maria Alice Rodrigues Marques da Silva
    • 2
  • Anabela Pereira da Silva Tavares
    • 3
  1. 1.Hospital Garcia de OrtaAlmadaPortugal
  2. 2.Centro Clinico SAMS LisboaLisboaPortugal
  3. 3.Psychiatric DepartmentCoimbra Psychiatric Hospital Centre - Sobral Cid UnitCoimbraPortugal
  4. 4.Departamento de Psiquiatr?íaCentro Hospitalar Psiquiátrico de Coimbra-Unidade Sobral CidCoimbraPortugal

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