Background: The objective of the FALCOFORTE programme was to demonstrate the efficacy and safety of 3 months of therapy with the fixed combination perindopril/indapamide in hypertensive patients in everyday medical practice.
Design and methods: Patients with blood pressure >140/90mmHgor with blood pressure >130/85mmHg and three or more risk factors were prescribed perindopril/indapamide 2.5/0.625mg or 5/1.25 mg. Dosage could be increased to 10/2.5mg at any time during the study.
Results: Of the 2327 patients included, 69% of patients had been unsuccessfully treated with other antihypertensives, 4.6% had not tolerated previous antihypertensive treatments, and 26.8% were newly diagnosed hypertensive patients. Roughly half the cohort was at high or very high cardiovascular risk. After 3 months of therapy, systolic blood pressure decreased from 156.9 ± 13.7 to 132.3 ± 10.6mmHg (p < 0.0001) and diastolic blood pressure from 94.9 ± 8.2 to 81.3 ± 6.3 mmHg (p < 0.0001). Target blood pressure was reached by 87.1% of patients. Similar changes from baseline were observed in patients with diabetes mellitus, metabolic syndrome or left ventricular hypertrophy (p < 0.0001). When blood pressure decreases were analysed by dose, changes from baseline increased with increasing doses. Perindopril/indapamide was well tolerated with no significant changes in laboratory parameters being observed. Quality of life improved significantly.
Conclusions: Therapy with fixed combination perindopril/indapamide was effective and well tolerated in a wide range of patients.
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This study was supported by a research grant from SERVIER. The author has no conflicts of interest to declare. The author would like to thank to all the physicians who participated in this study and Hélène Dassule, PhD, for her editorial support.
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Pella, D. Efficacy and Safety of Treatment of Hypertensive Patients with Fixed Combination Perindopril/Indapamide Up to 10/2.5mg. High Blood Press Cardiovasc Prev 18, 107–113 (2011). https://doi.org/10.2165/11593520-000000000-00000