, Volume 25, Issue 2, pp 89–103 | Cite as

Tacrolimus in the Treatment of Ocular Diseases

  • Jiajie Zhai
  • Jianjun Gu
  • Jin YuanEmail author
  • Jiaqi ChenEmail author
Review Article


Tacrolimus (FK506) has been used successfully as a systemic immunomodulator for more than 2 decades, and numerous studies have investigated its mechanisms of action. Systemic and topical tacrolimus have been investigated as treatments for ocular surface disorders that may have an immune-based inflammatory component. In these studies, tacrolimus has shown efficacy in corneal graft rejection, inflammatory conjunctival and corneal diseases, uveitis, and graft-versus-host disease. As these disorders are often refractory to other available treatments, ophthalmic or systemic tacrolimus is a welcome nontoxic adjunct or replacement to potentially toxic topical or systemic immunosuppressive therapies.


Tacrolimus Uveitis Ocular Surface Corneal Graft Tacrolimus Ointment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the Fundamental Research Funds of State Key Lab (Grant number 303060202400413).The authors have no conflicts of interest that are directly relevant to the content of this review.


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Copyright information

© Adis Data Information BV 2011

Authors and Affiliations

  1. 1.State Key Laboratory of OphthalmologyZhongshan Ophthalmic Center, Sun Yat-sen UniversityGuangzhouChina
  2. 2.Institute of Ophthalmology and Visual Sciences of Guangdong ProvinceGuangzhouChina

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