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Botanical Extracts as Anti-Aging Preparations for the Skin

A Systematic Review

Abstract

Although topical creams and other anti-aging products purport to reduce the appearance of aging and skin wrinkling, there has been no critical analysis in the scientific literature of their effectiveness.

This systematic review critically evaluates the evidence for the effectiveness or efficacy of botanical treatments in reducing skin aging and wrinkling. MEDLINE, Embase, CINAHL®, CENTRAL and AMED databases were searched from their inception until October 2009. Reference lists of retrieved articles were hand-searched. Manufacturers and professional associations were contacted in order to identify further non-published studies. No language restrictions were applied. Only randomized clinical trials or controlled clinical trials assessing the effectiveness of botanical extracts in reducing wrinkling and aging of the skin were included. Data were extracted by two independent reviewers and methodological quality was assessed using the Jadad score and key aspects of the Cochrane risk of bias tool.

Of 36 potentially relevant studies, 11 trials of botanical extracts for reducing skin wrinkling and the appearance of aging met all the inclusion criteria. No trials were identified following contact with anti-aging and cosmetic organizations, companies and professional bodies. A significant reduction in skin wrinkling was noted for date kernel extract, cork extract, soy extract, Rosaceae and peony extract. No significant reduction was noted for green tea, Vitaphenol® (a combination of green and white teas, mangosteen and pomegranate extract) or maca root. All trials were of poor methodological quality. Adverse effects were frequently not reported.

In summary, there is some weak evidence to suggest that several botanical extracts may be effective in reducing the appearance of skin aging but no evidence that this effect is enduring. Independent replications with larger, more diverse samples, longer treatment durations and more rigorous study designs are required to validate these preliminary findings.

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References

  1. 1.

    GAO. Health products for seniors: ‘anti-aging’ products pose potential for physical and economic harm. Report to Chairman, Special Committee on Aging, US Senate. Washington, DC: Government Accountability Office, 2001 Sep

  2. 2.

    Olshansky SJ, Hayflick L, Carnes BA. Position statement on human ageing. J Gerontol A Biol Sci Med Sci 2002; 57A: B292–7

  3. 3.

    Perls TT. Hope drives antiaging hype. Cleveland Clin J Med 2006; 73: 1039–44

  4. 4.

    Harris Interactive Inc. Anti-aging medicine, vitamins, minerals and food supplements: a public opinion survey conducted for the International Longevity Center. J Anti Aging Med 2003; 6: 83–90

  5. 5.

    Gorman C. Face-lift in a jar? Time 2000; 14 Aug: 48–52

  6. 6.

    Thornefeldt C. Cosmeceuticals containing herbs: fact, fiction and future. Dermatol Surg 2005; 37: 873–80

  7. 7.

    Baumann LS. Less-known cosmeceuticals. Dermatol Ther 2007; 20: 330–42

  8. 8.

    Bogdan Allemann I, Baumann L. Antioxidants used in skincare formulations. Skin Ther Lett 2008; 13: 1–12

  9. 9.

    Chiu A, Kimball AB. Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage. Br J Dermatol 2003; 149: 681–91

  10. 10.

    Kamel NS, Gammack J, Cepeda O, et al. Antioxidants and hormones as antiaging therapies: high hopes, disappointing results. Cleveland Clin J Med 2006; 73: 1049–56

  11. 11.

    Gao XH, Zhang L, Wei H, et al. Efficacy and safety of innovative cosmeceuticals. Clin Dermatol 2008; 26: 367–74

  12. 12.

    Calasanti T, King N. ‘Beware of the estrogen assault’: ideals of old manhood in anti-aging advertisements. J Aging Studies 2007; 21: 357–68

  13. 13.

    Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17: 1–12

  14. 14.

    Cochrane Collaboration. Risk of bias tool [online]. Available from URL: http://www.ohg.cochrane.org/forms/Risk%20of%20bias%20assessment%20tool.pdf [Accessed 2010 Aug 12]

  15. 15.

    Bauza E, Dal Farra C, Berghi A, et al. Date palm kernel extract exhibits antiaging properties and significantly reduces skin wrinkles. Int J Tissue React 2002; 24: 131–6

  16. 16.

    Chiu AE, Chan JL, Kern DG, et al. Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histological appearance of photoaging skin. Dermatol Surg 2005; 31: 855–9

  17. 17.

    Coquet C, Bauza E, Oberto G, et al. Quercus suber cork extract displays a tensor and smoothing effect on human skin: an in vivo study. Drugs Exp Clin Res 2005; 31: 89–99

  18. 18.

    Garnier S, Bredif S, Legrand JL, et al. Oligosaccharidic and peptidic extract from maca root: a new cell energizer with clinical anti-aging properties [abstract no. P02.18]. In: 14th Congress of the European Academy of Dermatology and Venereology; 2005 Oct 12–15; London. J Eur Acad Dermatol Venereol 2005; 19Suppl. 2: 47

  19. 19.

    Hsu J, Skover G, Goldman MP. Evaluating the efficacy in improving facial damage with a mixture of topical antioxidant. J Drugs Dermatol 2007; 6: 1141–8

  20. 20.

    Izumi T, Saito M, Obata A, et al. Oral intake of soy isoflavone aglycone improves the aged skin of adult women. J Nutr Sci Vitaminol 2007; 53: 57–62

  21. 21.

    Janjua R, Munoz C, Gorell E, et al. A two-year, doubleblind, placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histological appearance of photoaging skin. Dermatol Surg 2009; 35: 1–9

  22. 22.

    Kim YH, Chung CB, Kim JG, et al. Anti-wrinkle activity of Ziuglycoside I isolated from Sanguisorba officianalis root extract and its application as a cosmeceutical ingredient. Biosci Biotechnol Biochem 2008; 72: 303–11

  23. 23.

    Lee S, Lim JM, Jin MH, et al. Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin. J Cosmet Sci 2006; 57: 57–64

  24. 24.

    Martelli L, Beradesca E, Martelli M. Topical formulation of a new plant extract complex with refirming properties: clinical and non-invasive evaluation in a double-blind trial. Int J Cosmet Sci 2000 Jun; 22(3): 201–6

  25. 25.

    Syed TA, Ahmad SA, Wong W, et al. Clinical evaluation of 2 polyphenone (green tea extract) in a hydrophilic gel to assess improvement in aged and damaged facial skin: a placebo-controlled, double-blind study [abstract]. 20th World Congress of Dermatology; 2002 Jul 1–5; Paris

  26. 26.

    Gagnier JJ, Boon H, Rochon P, et al. Reporting randomized-controlled trials of herbal interventions: an elaborated CONSORT statement. Ann Intern Med 2006; 144: 364–7

  27. 27.

    Moher D, Schultz KF, Altman DG. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 2001; 357: 1191–4

  28. 28.

    Ernst E, Pittler M. Alternative therapy bias [letter]. Nature 1997; 385: 480

  29. 29.

    Cochrane Collaboration. Cochrane handbook: defining types of study [online]. Available from URL: http://www.cochrane-handbook.org/ [Accessed 2009 Feb 27]

  30. 30.

    Ernst E. ‘First do no harm’ with complementary and alternative medicine. Trends Pharmacol Sci 2007; 28: 48–50

  31. 31.

    Chan TYK. Monitoring the safety of herbal medicines. Drug Saf 1997; 17: 209–15

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Acknowledgements

The contribution of S.K. Hung to this review was funded by Schwabe Pharmaceuticals, which researches and develops plant-based medicines and healthcare products but is not a manufacturer of skincare or anti-aging products. No other external sources of funding were used to assist in the conduct or writing of this review. The authors have no conflicts of interest that are directly relevant to the content of this review. The authors thank Leala Watson for advice and help in designing the literature search strategy.

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Correspondence to Katherine J. Hunt.

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Hunt, K.J., Hung, S.K. & Ernst, E. Botanical Extracts as Anti-Aging Preparations for the Skin. Drugs Aging 27, 973–985 (2010). https://doi.org/10.2165/11584420-000000000-00000

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Keywords

  • Jadad Score
  • Paeoniflorin
  • Longe Treatment Duration
  • Pomegranate Extract
  • Placebo Cream