Drug Safety

, Volume 33, Issue 7, pp 535–538 | Cite as

Recurrence of Adverse Drug Reactions following Inappropriate Re-Prescription

Better Documentation, Availability of Information and Monitoring are Needed
  • Carolien M. J. van der Linden
  • Paul A. F. Jansen
  • Rob J. van Marum
  • René J. E. Grouls
  • Erik H. M. Korsten
  • Antoine C. G. Egberts
Current Opinion


Adverse drug reactions (ADRs) are a common, and often preventable, cause of hospital admission, especially in the elderly, and can occur during hospitalization.

In this current opinion article, we present three cases of recurrence of a serious ADR due to re-prescription of a withdrawn medication that highlight the need for a system to prevent the undesirable re-prescription of medications withdrawn because of an ADR. In addition, we describe an electronic system that could help prevent undesirable re-prescription following an ADR. Such a system should document ADRs systematically at the patient level, make this information available to relevant healthcare providers and the patient, and flag re-prescription of the offending drug. The effectiveness and cost effectiveness of such a system would need to be determined.


Haloperidol Hydrochlorothiazide Pamidronate Selegiline Pergolide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Carolien van der Linden was financially supported by Catharina Hospitals Science Fund, which had no role in any of the following: design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review or approval of the manuscript.

All authors declare that they have no conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in this current opinion article.


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Copyright information

© Adis Data Information BV 2010

Authors and Affiliations

  • Carolien M. J. van der Linden
    • 1
  • Paul A. F. Jansen
    • 2
  • Rob J. van Marum
    • 2
    • 3
  • René J. E. Grouls
    • 1
  • Erik H. M. Korsten
    • 1
    • 4
  • Antoine C. G. Egberts
    • 2
    • 5
  1. 1.Catharina HospitalEindhoventhe Netherlands
  2. 2.University Medical Centre UtrechtUtrechtthe Netherlands
  3. 3.Jeroen Bosch Hospital’s-Hertogenboschthe Netherlands
  4. 4.Eindhoven University of TechnologyEindhoventhe Netherlands
  5. 5.Utrecht Institute for Pharmaceutical SciencesUtrechtthe Netherlands

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