American Journal of Clinical Dermatology

, Volume 12, Issue 1, pp 63–67 | Cite as

Cetuximab-Associated Elongation of the Eyelashes

Case Report and Review of Eyelash Trichomegaly Secondary to Epidermal Growth Factor Receptor Inhibitors
  • Philip R. CohenEmail author
  • Susan M. Escudier
  • Razelle Kurzrock
Case Reports Cetuximab-Associated Eyelash Trichomegaly


Eyelash trichomegaly is an uncommon drug-associated sequelae experienced during treatment with epidermal growth factor receptor (EGFR) inhibitors. Elongation of the eyelashes induced by these agents has predominantly been observed in oncology patients with either colorectal or lung cancer. It is most frequently associated with cetuximab and erlotinib; however, it has also been described in individuals treated with gefitinib or panitumumab. We describe cetuximab-associated eyelash trichomegaly in a woman with metastatic rectal carcinoma. We review the clinical presentation, adverse effects, and management of EGFR inhibitor-related eyelash trichomegaly. The long eyelashes are not a drug-limiting adverse effect and some patients consider the change to be cosmetically enhancing. Trimming the lashes with scissors can usually ameliorate local symptoms. The eyelashes often return to their original length at variable time periods after EGFR inhibitor therapy is discontinued.


Epidermal Growth Factor Receptor Irinotecan Cetuximab Gefitinib Erlotinib 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



No sources of funding were used to prepare this case report. The authors have no conflicts of interest that are directly relevant to the content of this case report.


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Copyright information

© Adis Data Information BV 2011

Authors and Affiliations

  • Philip R. Cohen
    • 1
    • 2
    • 3
    Email author
  • Susan M. Escudier
    • 4
  • Razelle Kurzrock
    • 5
  1. 1.The University of Houston Health CenterUniversity of HoustonHoustonUSA
  2. 2.Department of DermatologyUniversity of Texas-Houston Medical SchoolHoustonUSA
  3. 3.Department of DermatologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  4. 4.Texas Oncology P.A.HoustonUSA
  5. 5.Department of Clinical Therapeutics (a Phase I Program)The University of Texas MD Anderson Cancer CenterHoustonUSA

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